Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5736369 | 0.76 | LMNA (0.43) | FLT3KDM4EL3MBTL1ALDH1A1DRD3 | |
| SCHEMBL3690875 | 0.74 | HTR7 (0.40) | FLT3KDM4EL3MBTL1DRD3APAF1 | |
| SCHEMBL3690211 | 0.72 | MAOB (0.37) | KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL2532889 | 0.72 | ACHE (0.43) | FLT3KDM4EALDH1A1DRD3CYP1A2 | |
| SCHEMBL24568765 | 0.71 | KDR (0.46) | FLT3KDM4EL3MBTL1EGFRRAD52 | |
| SCHEMBL21541819 | 0.71 | TAAR1 (0.47) | FLT3KDM4EL3MBTL1ALDH1A1EGFR | |
| SCHEMBL3695443 | 0.69 | ALDH1A1 (0.35) | KDM4EALDH1A1MEN1CYP1A2CYP2D6 | |
| SCHEMBL15301101 | 0.68 | NOS2 (0.45) | FLT3EGFRCYP1A2 | |
| SCHEMBL2278503 | 0.68 | HTR7 (0.46) | ALDH1A1RAD52CYP1A2CYP2D6 | |
| SCHEMBL31453711 | 0.67 | L3MBTL1 (0.44) | FLT3KDM4EL3MBTL1DRD3APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |
| EP-1506158-A2 | DIAMINO-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097576-A2 | DIAMINO-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2003-11-27 | — | — | WO | disclosed |