Sugi Predict

Sugi Predict / Compounds / SCHEMBL369290

SCHEMBL369290

SCHEMBL369290

O=C(O)c1cc(-c2cccnc2)on1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.70
▸ PTPN1 P18031 2/20 0.66
▸ SCD O00767 3/20 0.60
▸ SCD5 Q86SK9 2/20 0.60
▸ RAB9A P51151 2/20 0.56
▸ KMT2A Q03164 2/20 0.56
▸ SMN1; SMN2 Q16637 2/20 0.56
▸ KMO O15229 2/20 0.55
▸ HPGD P15428 3/20 0.55
▸ MAPT P10636 5/20 0.52
▸ TP53 P04637 2/20 0.52
▸ POLB P06746 1/20 0.52
▸ MEN1 O00255 1/20 0.51
▸ NPC1 O15118 1/20 0.51
▸ PKM P14618 1/20 0.51
▸ RECQL P46063 1/20 0.51
▸ MKNK1 Q9BUB5 2/20 0.50
▸ MKNK2 Q9HBH9 2/20 0.50
▸ L3MBTL1 Q9Y468 1/20 0.50
▸ TDP1 Q9NUW8 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31039788 1.00 ALDH1A1 (0.70) ALDH1A1PTPN1SCDSCD5RAB9A
SCHEMBL17788518 0.86 SCD (0.55) ALDH1A1PTPN1SCDSCD5RAB9A
SCHEMBL30589115 0.86 SCD (0.55) ALDH1A1PTPN1SCDSCD5RAB9A
SCHEMBL368236 0.86 SCD (0.55) ALDH1A1PTPN1SCDSCD5RAB9A
SCHEMBL71299 0.83 ALDH1A1 (1.00) ALDH1A1PTPN1RAB9AKMT2ASMN1; SMN2
SCHEMBL13363887 0.82 TP53 (0.59) ALDH1A1SCDSCD5RAB9AKMT2A
SCHEMBL3413851 0.82 RAB9A (0.62) ALDH1A1SCDSCD5RAB9AKMT2A
SCHEMBL4406520 0.80 ALDH1A1 (0.73) ALDH1A1PTPN1SCDSCD5RAB9A
SCHEMBL4318440 0.80 CYP3A4 (0.62) ALDH1A1SCDSCD5RAB9ASMN1; SMN2
SCHEMBL5620215 0.80 PTPN1 (1.00) ALDH1A1PTPN1RAB9AKMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1971600-B1 ISOXAZOLE DERIVATIVES AND USE THEREOF SK BIOPHARMACEUTICALS CO LTD (KR) 2013-08-21 — — EP claimed
US-20090131336-A1 Isoxazole Derivatives and Use Thereof SK BIOPHARMACEUTICALS CO., LTD. (KR) 2009-05-21 — — US claimed
EP-1971600-A1 ISOXAZOLE DERIVATIVES AND USE THEREOF SK Holdings Co., Ltd. (KR) 2008-09-24 — — EP claimed
WO-2007078113-A1 ISOXAZOLE DERIVATIVES AND USE THEREOF SK HOLDINGS CO., LTD. (KR) 2007-07-12 — — WO claimed
US-12421210-B2 Fused bicyclic heterocycles as therapeutic agents NEW YORK UNIVERSITY (US) 2025-09-23 — — US disclosed
US-12325702-B2 ATF6 inhibitors and uses thereof ALTOS LABS, INC. (US) 2025-06-10 — — US disclosed
US-20240124434-A1 ATF6 INHIBITORS AND USES THEREOF ALTOS LABS, INC. 2024-04-18 — — US disclosed
EP-3856735-B1 FUSED BICYCLIC HETEROCYCLES AS THERAPEUTIC AGENTS UNIV NEW YORK (US) 2023-09-06 — — EP disclosed
US-20210395222-A1 Fused Bicyclic Heterocycles as Therapeutic Agents NEW YORK UNIVERSITY 2021-12-23 — — US disclosed
EP-3856735-A1 FUSED BICYCLIC HETEROCYCLES AS THEREAPEUTIC AGENTS New York University (US) 2021-08-04 — — EP disclosed
US-20210221803-A1 ATF6 INHIBITORS AND USES THEREOF ALTOS LABS, INC. 2021-07-22 — — US disclosed
US-20210221803-A1 ATF6 INHIBITORS AND USES THEREOF ALTOS LABS, INC. 2021-07-22 — — US disclosed
US-20120094837-A1 Novel Heterocyclic Compounds as Pesticides BAYER CROP SCIENCE AG (DE) 2012-04-19 — — US disclosed
US-20120094837-A1 Novel Heterocyclic Compounds as Pesticides BAYER CROP SCIENCE AG (DE) 2012-04-19 — — US disclosed
US-20120094837-A1 Novel Heterocyclic Compounds as Pesticides BAYER CROP SCIENCE AG (DE) 2012-04-19 — — US disclosed
WO-2012007500-A2 NEW HETEROCYCLIC COMPOUNDS AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2012-01-19 — — WO disclosed
WO-2012007500-A2 NEW HETEROCYCLIC COMPOUNDS AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2012-01-19 — — WO disclosed
US-20090131336-A1 Isoxazole Derivatives and Use Thereof SK BIOPHARMACEUTICALS CO., LTD. (KR) 2009-05-21 — — US disclosed
EP-1971600-A1 ISOXAZOLE DERIVATIVES AND USE THEREOF SK Holdings Co., Ltd. (KR) 2008-09-24 — — EP disclosed
WO-2007078113-A1 ISOXAZOLE DERIVATIVES AND USE THEREOF SK HOLDINGS CO., LTD. (KR) 2007-07-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240124434-A1 ATF6 INHIBITORS AND USES THEREOF ATF4, XBP1, ATF1 ALDH1A1 4447/4885PTPN1 3636/4885SCD 2364/4885
US-12325702-B2 ATF6 inhibitors and uses thereof ATF4, XBP1, ATF1 ALDH1A1 4447/4885PTPN1 3636/4885SCD 2364/4885
US-12421210-B2 Fused bicyclic heterocycles as therapeutic agents NAMPT, NQO1, NAPRT ALDH1A1 1562/4885PTPN1 4644/4885SCD 294/4885
US-20210221803-A1 ATF6 INHIBITORS AND USES THEREOF ATF4, XBP1, ATF1 ALDH1A1 4447/4885PTPN1 3636/4885SCD 2364/4885
US-20120094837-A1 Novel Heterocyclic Compounds as Pesticides DDT, PTMS, ACHE ALDH1A1 2531/4885PTPN1 2995/4885SCD 3391/4885
US-20210395222-A1 Fused Bicyclic Heterocycles as Therapeutic Agents NAMPT, NQO1, NAPRT ALDH1A1 1562/4885PTPN1 4644/4885SCD 294/4885
US-20090131336-A1 Isoxazole Derivatives and Use Thereof WNT3A, WNT1, WNT3 ALDH1A1 706/4885PTPN1 2026/4885SCD 3244/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.