Sugi Predict

Sugi Predict / Compounds / SCHEMBL4406520

SCHEMBL4406520

SCHEMBL4406520

O=C(O)c1cc(-c2ccncc2)on1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.73
▸ PTPN1 P18031 2/20 0.67
▸ HPGD P15428 4/20 0.61
▸ MAPT P10636 2/20 0.61
▸ RECQL P46063 1/20 0.61
▸ CDH1 P12830 1/20 0.56
▸ CTNNB1 P35222 1/20 0.56
▸ TCF7L2 Q9NQB0 1/20 0.56
▸ SCD O00767 4/20 0.55
▸ SCD5 Q86SK9 3/20 0.55
▸ RAB9A P51151 4/20 0.53
▸ NPC1 O15118 3/20 0.53
▸ KMT2A Q03164 3/20 0.53
▸ SMN1; SMN2 Q16637 3/20 0.53
▸ MEN1 O00255 2/20 0.53
▸ PKM P14618 1/20 0.53
▸ RARA P10276 1/20 0.50
▸ RARB P10826 1/20 0.50
▸ RARG P13631 1/20 0.50
▸ RXRA P19793 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL71299 0.85 ALDH1A1 (1.00) ALDH1A1PTPN1HPGDMAPTRECQL
SCHEMBL72786 0.81 ALDH1A1 (1.00) ALDH1A1PTPN1HPGDMAPTRECQL
SCHEMBL1178695 0.80 ALDH1A1 (0.72) ALDH1A1PTPN1HPGDMAPTRECQL
SCHEMBL3227675 0.80 PTPN1 (1.00) ALDH1A1PTPN1HPGDMAPTRECQL
SCHEMBL72428 0.80 ALDH1A1 (0.72) ALDH1A1PTPN1HPGDMAPTRECQL
SCHEMBL892878 0.80 ALDH1A1 (0.72) ALDH1A1PTPN1HPGDMAPTRECQL
SCHEMBL892967 0.80 CDH1 (0.82) ALDH1A1PTPN1HPGDMAPTRECQL
SCHEMBL31039788 0.80 ALDH1A1 (0.70) ALDH1A1PTPN1HPGDMAPTRECQL
SCHEMBL22322454 0.80 HPGD (0.55) ALDH1A1HPGDMAPTSCDSCD5
SCHEMBL4398685 0.80 ALDH1A1 (0.66) ALDH1A1PTPN1HPGDMAPTRECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1971600-B1 ISOXAZOLE DERIVATIVES AND USE THEREOF SK BIOPHARMACEUTICALS CO LTD (KR) 2013-08-21 — — EP claimed
US-20090131336-A1 Isoxazole Derivatives and Use Thereof SK BIOPHARMACEUTICALS CO., LTD. (KR) 2009-05-21 — — US claimed
EP-1971600-A1 ISOXAZOLE DERIVATIVES AND USE THEREOF SK Holdings Co., Ltd. (KR) 2008-09-24 — — EP claimed
WO-2007078113-A1 ISOXAZOLE DERIVATIVES AND USE THEREOF SK HOLDINGS CO., LTD. (KR) 2007-07-12 — — WO claimed
US-12325702-B2 ATF6 inhibitors and uses thereof ALTOS LABS, INC. (US) 2025-06-10 — — US disclosed
CN-119060036-A ATF6 inhibitors and uses thereof 阿尔托斯实验室公司 2024-12-03 — — CN disclosed
CN-112313224-B ATF6 inhibitors and uses thereof 阿尔托斯实验室公司 2024-08-13 — — CN disclosed
US-20240124434-A1 ATF6 INHIBITORS AND USES THEREOF ALTOS LABS, INC. 2024-04-18 — — US disclosed
US-20220104493-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-04-07 — — US disclosed
EP-3920701-A1 HERBICIDAL COMPOUNDS Syngenta Crop Protection AG (CH) 2021-12-15 — — EP disclosed
CN-113412055-A Herbicidal compounds 先正达农作物保护股份公司 2021-09-17 — — CN disclosed
US-20210221803-A1 ATF6 INHIBITORS AND USES THEREOF ALTOS LABS, INC. 2021-07-22 — — US disclosed
CN-112313224-A ATF6 inhibitors and uses thereof 黑带医疗有限责任公司 2021-02-02 — — CN disclosed
US-10829485-B2 ATF6 inhibitors and uses thereof BLACK BELT TX LTD (GB) 2020-11-10 — — US disclosed
US-10829485-B2 ATF6 inhibitors and uses thereof BLACK BELT TX LTD (GB) 2020-11-10 — — US disclosed
WO-2020161163-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-08-13 — — WO disclosed
US-20190330198-A1 COMPOUNDS AND USES THEREOF JANSSEN PHARMACEUTICA NV (BE) 2019-10-31 — — US disclosed
US-20190330198-A1 COMPOUNDS AND USES THEREOF JANSSEN PHARMACEUTICA NV (BE) 2019-10-31 — — US disclosed
EP-1971600-B1 ISOXAZOLE DERIVATIVES AND USE THEREOF SK BIOPHARMACEUTICALS CO LTD (KR) 2013-08-21 — — EP disclosed
US-20090131336-A1 Isoxazole Derivatives and Use Thereof SK BIOPHARMACEUTICALS CO., LTD. (KR) 2009-05-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240124434-A1 ATF6 INHIBITORS AND USES THEREOF ATF4, XBP1, ATF1 ALDH1A1 4447/4885PTPN1 3636/4885HPGD 2636/4885
US-12325702-B2 ATF6 inhibitors and uses thereof ATF4, XBP1, ATF1 ALDH1A1 4447/4885PTPN1 3636/4885HPGD 2636/4885
US-20220104493-A1 HERBICIDAL COMPOUNDS DDT, ACHE, GSTO1 ALDH1A1 32/4885PTPN1 808/4885HPGD 1674/4885
US-10829485-B2 ATF6 inhibitors and uses thereof ATF4, XBP1, ATF1 ALDH1A1 4447/4885PTPN1 3636/4885HPGD 2636/4885
US-20210221803-A1 ATF6 INHIBITORS AND USES THEREOF ATF4, XBP1, ATF1 ALDH1A1 4447/4885PTPN1 3636/4885HPGD 2636/4885
US-20190330198-A1 COMPOUNDS AND USES THEREOF NLN, ACHE, CLN6 ALDH1A1 656/4885PTPN1 4301/4885HPGD 565/4885
US-20090131336-A1 Isoxazole Derivatives and Use Thereof WNT3A, WNT1, WNT3 ALDH1A1 706/4885PTPN1 2026/4885HPGD 732/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.