Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | KCNQ3 | O43525 | 4/20 | 0.31 |
| ▸ | KCNQ2 | O43526 | 4/20 | 0.31 |
| ▸ | KCNE1 | P15382 | 4/20 | 0.31 |
| ▸ | KCNQ1 | P51787 | 4/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371335 | 0.81 | RAB9A (0.32) | RAB9ASMN1; SMN2NPC1ALDH1A1HTT | |
| SCHEMBL370104 | 0.78 | RAB9A (0.33) | HDAC1RAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL364975 | 0.76 | GPBAR1 (0.30) | GPBAR1 | |
| SCHEMBL363181 | 0.70 | HDAC3 (0.38) | HDAC1ALDH1A1HDAC3HDAC2HDAC6 | |
| SCHEMBL362323 | 0.70 | KCNN4 (0.41) | HDAC1ALDH1A1KCNE1KCNQ1MEN1 | |
| SCHEMBL363897 | 0.68 | AR (0.36) | RAB9ASMN1; SMN2NPC1ALDH1A1MEN1 | |
| SCHEMBL362974 | 0.68 | KCNN4 (0.35) | RAB9AALDH1A1KCNE1KCNQ1HDAC6 | |
| SCHEMBL361971 | 0.65 | NR1H2 (0.37) | RAB9ASMN1; SMN2NPC1ALDH1A1HTT | |
| SCHEMBL364587 | 0.65 | SORT1 (0.34) | ALDH1A1 | |
| SCHEMBL363084 | 0.65 | SORT1 (0.34) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |