Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9960469 | 0.92 | HDAC6 (0.71) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL15443123 | 0.90 | HDAC1 (0.59) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL31688425 | 0.88 | HDAC6 (0.62) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL365881 | 0.88 | HDAC6 (0.62) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL15104883 | 0.86 | HDAC6 (0.64) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL2015553 | 0.85 | HDAC6 (0.61) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL14949142 | 0.85 | HDAC6 (0.58) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL14700702 | 0.85 | HDAC6 (0.58) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL15450787 | 0.85 | HDAC6 (0.58) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL14700719 | 0.85 | HDAC6 (0.69) | HDAC6HDAC1HDAC3HDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987469-B2 | Process for the preparation of bendamustine | HEYL CHEMISCH-PHARMAZEUTISCHE FABRIK GMBH & CO. KG (DE) | 2015-03-24 | — | — | US | claimed |
| EP-2690096-B1 | Process for preparation of Bendamustine | HEYL CHEM PHARM (DE) | 2014-11-26 | — | — | EP | claimed |
| US-20140031560-A1 | PROCESS FOR THE PREPARATION OF BENDAMUSTINE | HEYL CHEMISCH-PHARMAZEUTISCHE FABRIK GMBH & CO. KG (DE) | 2014-01-30 | — | — | US | claimed |
| EP-2690096-A1 | Process for preparation of Bendamustine | HEYL Chemisch-Pharmazeutische Fabrik GmbH und Co. KG (DE) | 2014-01-29 | — | — | EP | claimed |
| US-10252999-B2 | Process for preparing alkyl esters of 4-(5-(bis(2-hydroxyethyl)amino-1-methyl-1H-benzo[D]imidazol-2-yl)butyric acid | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2019-04-09 | — | — | US | disclosed |
| US-20180105499-A1 | PROCESS FOR PREPARING ALKYL ESTERS OF 4-(5-(BIS(2-HYDROXYETHYL)AMINO-1-METHYL-1H-BENZO[D]IMIDAZOL-2-YL)BUTYRIC ACID | MACFARLAN SMITH LIMITED (GB) | 2018-04-19 | — | — | US | disclosed |
| US-8987469-B2 | Process for the preparation of bendamustine | HEYL CHEMISCH-PHARMAZEUTISCHE FABRIK GMBH & CO. KG (DE) | 2015-03-24 | — | — | US | disclosed |
| US-8987469-B2 | Process for the preparation of bendamustine | HEYL CHEMISCH-PHARMAZEUTISCHE FABRIK GMBH & CO. KG (DE) | 2015-03-24 | — | — | US | disclosed |
| EP-2690096-B1 | Process for preparation of Bendamustine | HEYL CHEM PHARM (DE) | 2014-11-26 | — | — | EP | disclosed |
| US-20140275567-A1 | PROCESS FOR PREPARING ALKYL ESTERS OF 4-(5-(BIS(2-HYDROXYETHYL)AMINO)-1-METHYL-1H-BENZO[D]IMIDAZOL-2-YL)BUTYRIC ACID | JOHNSON MATTHEY PLC (GB) | 2014-09-18 | — | — | US | disclosed |
| US-20140031560-A1 | PROCESS FOR THE PREPARATION OF BENDAMUSTINE | HEYL CHEMISCH-PHARMAZEUTISCHE FABRIK GMBH & CO. KG (DE) | 2014-01-30 | — | — | US | disclosed |
| US-20140031560-A1 | PROCESS FOR THE PREPARATION OF BENDAMUSTINE | HEYL CHEMISCH-PHARMAZEUTISCHE FABRIK GMBH & CO. KG (DE) | 2014-01-30 | — | — | US | disclosed |
| EP-2690096-A1 | Process for preparation of Bendamustine | HEYL Chemisch-Pharmazeutische Fabrik GmbH und Co. KG (DE) | 2014-01-29 | — | — | EP | disclosed |
| EP-2690096-A1 | Process for preparation of Bendamustine | HEYL Chemisch-Pharmazeutische Fabrik GmbH und Co. KG (DE) | 2014-01-29 | — | — | EP | disclosed |
| US-20130317234-A1 | Process for Preparation of Intermediates of Bendamustine | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD (IN) | 2013-11-28 | — | — | US | disclosed |
| US-8481751-B2 | Process for the production of bendamustine alkyl ester, bendamustine, and derivatives thereof | HERAEUS PRECIOUS METALS GMBH & CO. KG (DE) | 2013-07-09 | — | — | US | disclosed |
| US-20120165543-A1 | PROCESS FOR THE PRODUCTION OF BENDAMUSTINE ALKYL ESTER, BENDAMUSTINE, AND DERIVATIVES THEREOF | HERAEUS PRECIOUS METALS GMBH & CO. KG (DE) | 2012-06-28 | — | — | US | disclosed |
| WO-2012007966-A3 | PROCESS FOR PREPARATION OF INTERMEDIATES OF BENDAMUSTINE | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012007966-A2 | PROCESS FOR PREPARATION OF INTERMEDIATES OF BENDAMUSTINE | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) | 2012-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165543-A1 | PROCESS FOR THE PRODUCTION OF BENDAMUSTINE ALKYL ESTER, BENDAMUSTINE, AND DERIVATIVES THEREOF | OTC, OAT, BCKDK | HDAC6 1763/4885HDAC1 2804/4885HDAC3 2766/4885 |
| US-20140031560-A1 | PROCESS FOR THE PREPARATION OF BENDAMUSTINE | OGDH, GCDH, BPGM | HDAC6 993/4885HDAC1 1465/4885HDAC3 1407/4885 |
| US-20130317234-A1 | Process for Preparation of Intermediates of Bendamustine | GABRB1, GABRB2, GABRB3 | HDAC6 1357/4885HDAC1 2415/4885HDAC3 2262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.