Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 7/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000747 | 0.76 | TRPA1 (0.42) | TRPA1 | |
| SCHEMBL7436002 | 0.72 | TRPA1 (0.42) | TRPA1CYP11B2MAOAMAOB | |
| SCHEMBL20613152 | 0.71 | TRPA1 (0.48) | TRPA1CYP11B2CYP11B1PTGS2MAOA | |
| SCHEMBL7500741 | 0.71 | MAOA (0.44) | TRPA1MAOAMAOB | |
| SCHEMBL3707900 | 0.68 | TRPA1 (0.46) | TRPA1CYP11B2CYP11B1MAOAMAOB | |
| SCHEMBL8024405 | 0.66 | MEN1 (0.45) | — | |
| SCHEMBL29370486 | 0.64 | PTGS2 (0.46) | TRPA1CYP11B2CYP11B1PTGS2MAOA | |
| SCHEMBL319633 | 0.64 | PTGS2 (0.46) | TRPA1CYP11B2CYP11B1PTGS2MAOA | |
| SCHEMBL7572467 | 0.64 | TRPA1 (0.55) | TRPA1CYP11B2CYP11B1PTGS2 | |
| SCHEMBL5026786 | 0.64 | TRPA1 (0.46) | TRPA1CYP11B2CYP11B1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001956-B1 | 2,3-BENZODIAZEPINE DERIVATIVES | GYOGYSZERKUTATO INTEZET (HU) | 2003-05-07 | — | — | EP | disclosed |
| US-6482819-B1 | 2,3-benzodiazepine derivatives | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2002-11-19 | — | — | US | disclosed |
| EP-1001956-A1 | NEW 2,3-BENZODIAZEPINE DERIVATIVES | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999006408-A1 | NEW 2,3-BENZODIAZEPINE DERIVATIVES | Gyógyszerkutató Intézet Kft. (HU) | 1999-02-11 | — | — | WO | disclosed |
| US-4322346-A | 5H-2,3-Benzodiazepine derivatives | KOROSI JENO | 1982-03-30 | — | — | US | disclosed |