Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 7/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 6/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5225822 | 0.78 | MEN1 (0.54) | PIM1PIM3PIM2HRH3AURKA | |
| SCHEMBL3656028 | 0.78 | ROCK2 (0.60) | PIM1PIM3PIM2HRH3KMO | |
| SCHEMBL3722649 | 0.77 | HTR7 (0.43) | PIM1PIM3PIM2HRH3KMO | |
| SCHEMBL3713494 | 0.77 | CDK2 (0.39) | KMOAURKACHUKPDPK1RPS6KB1 | |
| SCHEMBL3723622 | 0.77 | ROCK2 (0.42) | PIM1HRH3CDK2ROCK1PRKACA | |
| SCHEMBL3805901 | 0.73 | ROCK2 (0.58) | ROCK1 | |
| SCHEMBL3656027 | 0.72 | CDC7 (0.50) | PIM1PIM3PIM2KMOCDK2 | |
| SCHEMBL4703487 | 0.72 | MEN1 (0.53) | PIM1PIM3PIM2HRH3AURKA | |
| SCHEMBL3724438 | 0.72 | CYP1A2 (0.42) | HRH3 | |
| SCHEMBL3720566 | 0.70 | KMO (0.43) | KMOAURKACHUKPDPK1RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234618-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079008-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |