Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.32 |
| ▸ | GNAO1 | P09471 | 5/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.32 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.31 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1936310 | 0.88 | HSD11B1 (0.37) | HSD11B1TSHRGPR119GNAI3GNAO1 | |
| SCHEMBL8309136 | 0.85 | HSD11B1 (0.36) | HSD11B1GPR119GNAI3GNAO1GNAI1 | |
| SCHEMBL23089850 | 0.81 | HSD11B1 (0.46) | HSD11B1TSHRMBTD1L3MBTL3ITGB3 | |
| SCHEMBL20668089 | 0.79 | MBTD1 (0.46) | HSD11B1TSHRMBTD1L3MBTL3ITGB3 | |
| SCHEMBL144841 | 0.76 | GNAI3 (0.50) | TSHRGNAI3GNAO1GNAI1MBTD1 | |
| SCHEMBL4473669 | 0.76 | L3MBTL3 (0.44) | MBTD1L3MBTL3 | |
| SCHEMBL30484935 | 0.76 | CHRNB2 (0.44) | GNAI3GNAO1GNAI1L3MBTL3 | |
| SCHEMBL1934485 | 0.75 | DPP4 (0.37) | TSHRL3MBTL3 | |
| SCHEMBL18428929 | 0.75 | THRB (0.40) | — | |
| SCHEMBL14749013 | 0.75 | DPP4 (0.37) | GPR119SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138589-A1 | BICYCLIC PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE | GENENTECH, INC. (US) | 2010-12-02 | — | — | WO | disclosed |