Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | CCR5 | P51681 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3727160 | 0.86 | RORC (0.38) | HTR2AHTR2CAGTR2RORCCCR5 | |
| SCHEMBL3724780 | 0.77 | TAS2R14 (0.44) | HTR2AHTR2C | |
| SCHEMBL4783965 | 0.76 | CHRM2 (0.44) | OPRM1KMT2A | |
| SCHEMBL3722537 | 0.74 | OPRM1 (0.39) | HTR2AHTR2CAGTR2OPRM1 | |
| SCHEMBL3810612 | 0.74 | HTR2A (0.33) | HTR2AHTR2CAGTR2KMT2A | |
| SCHEMBL4911423 | 0.74 | HTR2A (0.33) | HTR2AHTR2CAGTR2KMT2A | |
| SCHEMBL3726385 | 0.74 | MEN1 (0.41) | KMT2A | |
| SCHEMBL3723935 | 0.73 | MCL1 (0.39) | HTR2AHTR2CKCNH2 | |
| SCHEMBL3728078 | 0.73 | HTR7 (0.37) | HTR2AHTR2CKMT2A | |
| SCHEMBL3808654 | 0.71 | OPRM1 (0.41) | CCR5OPRM1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155676-A2 | COMPOUNDS WITH ANTIPARASITIC ACTIVITY, APPLICATIONS THEREOF TO THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY APICOMPLEXANS | Commissariat à l'Energie Atomique (FR) | 2010-02-24 | — | — | EP | claimed |
| WO-2008146172-A2 | COMPOUNDS WITH ANTIPARASITIC ACTIVITY, APPLICATIONS THEREOF TO THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY APICOMPLEXANS | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2008-12-04 | — | — | WO | claimed |