Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | PPARG | P37231 | 4/20 | 0.58 |
| ▸ | PPARD | Q03181 | 4/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.58 |
| ▸ | RXRA | P19793 | 1/20 | 0.55 |
| ▸ | RXRB | P28702 | 1/20 | 0.55 |
| ▸ | RXRG | P48443 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30025989 | 1.00 | KDM4E (0.61) | KDM4EPPARGPPARDFFAR1RXRA | |
| SCHEMBL20591018 | 0.98 | KDM4E (0.60) | KDM4EPPARGPPARDFFAR1RXRA | |
| SCHEMBL30025954 | 0.92 | KDM4E (0.62) | KDM4EPPARGPPARDFFAR1RXRA | |
| SCHEMBL2914775 | 0.92 | KDM4E (0.62) | KDM4EPPARGPPARDFFAR1RXRA | |
| SCHEMBL13348919 | 0.89 | KDM4E (0.59) | KDM4EPPARGPPARDFFAR1DRD2 | |
| SCHEMBL6849640 | 0.85 | WDR5 (0.57) | KDM4EPPARGPPARDFFAR1RXRA | |
| SCHEMBL29447016 | 0.82 | LMNA (0.64) | KDM4EPPARGPPARDFFAR1RXRA | |
| SCHEMBL523934 | 0.82 | LMNA (0.64) | KDM4EPPARGPPARDFFAR1RXRA | |
| SCHEMBL11782966 | 0.82 | KDM4E (0.57) | KDM4EPPARGPPARDDRD2DRD4 | |
| SCHEMBL6846925 | 0.81 | KDM4E (0.58) | KDM4EPPARGPPARDFFAR1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539274-B1 | Method for the synthesis of aldehydes and of their derivatives | RHONE POULENC CHIMIE (FR) | 1996-04-10 | — | — | EP | claimed |
| EP-3704094-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2026-03-11 | — | — | EP | disclosed |
| US-20250122188-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2025-04-17 | — | — | US | disclosed |
| US-20240166652-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2024-05-23 | — | — | US | disclosed |
| EP-4356971-A2 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2024-04-24 | — | — | EP | disclosed |
| CN-117378604-A | Pesticide composition for stem and leaf treatment | 组合化学工业株式会社 | 2024-01-12 | — | — | CN | disclosed |
| CN-115947681-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2023-04-11 | — | — | CN | disclosed |
| US-20220363678-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-11-17 | — | — | US | disclosed |
| CN-109641844-B | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-11-01 | — | — | CN | disclosed |
| CN-108495553-B | Synergistic herbicidal composition | 江苏龙灯化学有限公司 | 2021-11-23 | — | — | CN | disclosed |
| US-20080154049-A1 | for acylation of an aromatic compound, comprising reacting an aromatic compound and an acylating agent of the carboxylic acid type, in the presence of a Lewis acid and of a silylated reagent selected from the group consisting of halosilanes and halosiloxanes. | SHASUN PHARMA SOLUTIONS LIMITED (GB) | 2008-06-26 | — | — | US | disclosed |
| WO-2008022242-A2 | SYNTHESIS OF PROPYL PHENOXY ETHERS AND USE AS DELIVERY AGENTS | EMISPHERE TECHNOLOGIES, INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| US-7214804-B2 | Heterocyclic compounds useful as growth hormone secretagogues | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-08 | — | — | US | disclosed |
| WO-2005070884-A2 | HETEROCYCLIC COMPOUNDS USEFUL AS GROWTH HORMONE SECRETAGOGUES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-08-04 | — | — | WO | disclosed |
| US-20050154043-A1 | Heterocyclic compounds useful as growth hormone secretagogues | BRISTOL-MYERS SQUIBB COMPANY | 2005-07-14 | — | — | US | disclosed |
| WO-2001045704-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-06-28 | — | — | WO | disclosed |
| US-6180830-B1 | REDUCING COMPLEX OF RUTHENIUM HAVING ELECTROVALENCY OF-4 AND COORDINATION NUMBER OF 6, WHEREIN AT LEAST ONE LIGAND IS TIN HALIDE, OTHER LIGANDS OPTIONALLY BEING HALOGEN ATOMS | RHODIA CHIMIE (FR) | 2001-01-30 | — | — | US | disclosed |
| EP-0068041-B1 | FLOWABLE HERBICIDE AND PESTICIDE COMPOSITIONS AND THEIR USE | J.T. Baker Chemical Co. (US) | 1985-08-21 | — | — | EP | disclosed |
| US-4389238-A | Flowable herbicide and pesticide formulation | J. T. BAKER CHEMICAL COMPANY (US) | 1983-06-21 | — | — | US | disclosed |
| EP-0068041-A1 | Flowable herbicide and pesticide compositions and their use | J.T. Baker Chemical Co. (US) | 1983-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250122188-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | KDM4E 4646/4885PPARG 724/4885PPARD 1954/4885 |
| US-20050154043-A1 | Heterocyclic compounds useful as growth hormone secretagogues | GHRHR, GHSR, CRH | KDM4E 3169/4885PPARG 716/4885PPARD 1437/4885 |
| US-20240166652-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | KDM4E 4646/4885PPARG 724/4885PPARD 1954/4885 |
| US-20220363678-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | KDM4E 4646/4885PPARG 724/4885PPARD 1954/4885 |
| US-20080154049-A1 | for acylation of an aromatic compound, comprising reacting an aromatic compound and an acylating agent of the carboxylic acid type, in the presence of a Lewis acid and of a silylated reagent selected from the group consisting of halosilanes and halosiloxanes. | AADAC, APEH, DDC | KDM4E 795/4885PPARG 823/4885PPARD 1801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.