Sugi Predict

Sugi Predict / Compounds / SCHEMBL3738359

SCHEMBL3738359

SCHEMBL3738359

O=C(O)Cc1cc(F)c(F)cc1Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABCB11 O95342 2/20 0.41
▸ PTGS1 P23219 2/20 0.41
▸ PTGS2 P35354 2/20 0.41
▸ NR1I3 Q14994 2/20 0.41
▸ PPARG P37231 1/20 0.41
▸ AKR1B1 P15121 2/20 0.41
▸ CA2 P00918 1/20 0.40
▸ CXCL8 P10145 6/20 0.40
▸ CAMK2A Q9UQM7 3/20 0.38
▸ CYP2C9 P11712 1/20 0.38
▸ CHRM1 P11229 1/20 0.38
▸ AKR1B10 O60218 1/20 0.38
▸ UGT1A9 O60656 1/20 0.38
▸ TRPA1 O75762 1/20 0.38
▸ MT-CO2 P00403 1/20 0.38
▸ TTR P02766 1/20 0.38
▸ ALB P02768 1/20 0.38
▸ UGT1A6 P19224 1/20 0.38
▸ UGT1A1 P22309 1/20 0.38
▸ CXCR1 P25024 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29718785 1.00 ABCB11 (0.41) ABCB11PTGS1PTGS2NR1I3PPARG
SCHEMBL7164323 0.90 ABCB11 (0.40) ABCB11PTGS1PTGS2NR1I3PPARG
SCHEMBL3329203 0.90 P2RX7 (0.40) ABCB11PTGS1PTGS2NR1I3PPARG
SCHEMBL927651 0.86 AKR1B1 (0.44) ABCB11PTGS1PTGS2NR1I3PPARG
SCHEMBL29159998 0.85 KDM1A (0.40) ABCB11PTGS1PTGS2NR1I3PPARG
SCHEMBL29718812 0.82 ICMT (0.44) TSHR
SCHEMBL297085 0.81 MRGPRX4 (0.41) ABCB11PTGS1PTGS2NR1I3PPARG
SCHEMBL332576 0.80 CXCL8 (0.43) AKR1B1CXCL8TSHR
SCHEMBL4837065 0.80 AKR1B1 (0.45) ABCB11PTGS1PTGS2NR1I3AKR1B1
SCHEMBL29362137 0.80 CXCL8 (0.43) AKR1B1CXCL8TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115054600-B Aromatic sulfonamide derivatives 拜耳制药股份公司 2024-06-14 — — CN disclosed
US-20230118751-A1 FUSED RING COMPOUND AND APPLICATION THEREOF WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD. (CN) 2023-04-20 — — US disclosed
US-11524938-B2 Aromatic sulfonamide derivatives BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2022-12-13 — — US disclosed
US-20220324807-A1 AROMATIC SULFONAMIDE DERIVATIVES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2022-10-13 — — US disclosed
CN-115054600-A Aromatic sulfonamide derivatives 拜耳制药股份公司 2022-09-16 — — CN disclosed
CN-114984003-A Aromatic sulfonamide derivatives 拜耳制药股份公司 2022-09-02 — — CN disclosed
CN-109415321-B Aromatic sulfonamide derivatives 拜耳制药股份公司 2022-06-17 — — CN disclosed
WO-2021136238-A1 FUSED RING COMPOUND AND APPLICATION THEREOF 武汉朗来科技发展有限公司 2021-07-08 — — WO disclosed
EP-3763704-A1 AROMATIC SULFONAMIDE DERIVATIVES Bayer Pharma Aktiengesellschaft (DE) 2021-01-13 — — EP disclosed
US-10844016-B2 Aromatic sulfonamide derivatives BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2020-11-24 — — US disclosed
EP-3458443-B1 AROMATIC SULFONAMIDE DERIVATIVES Bayer Pharma AG (DE) 2020-08-19 — — EP disclosed
US-20190119210-A1 AROMATIC SULFONAMIDE DERIVATIVES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2019-04-25 — — US disclosed
EP-3458443-A1 AROMATIC SULFONAMIDE DERIVATIVES Bayer Pharma Aktiengesellschaft (DE) 2019-03-27 — — EP disclosed
WO-2017191000-A9 AROMATIC SULFONAMIDE DERIVATIVES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-12-27 — — WO disclosed
WO-2017191000-A1 AROMATIC SULFONAMIDE DERIVATIVES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-11-09 — — WO disclosed
US-7829567-B2 Imino-indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same KAOHSIUNG MEDICAL UNIVERSITY (TW) 2010-11-09 — — US disclosed
US-20090111987-A1 Imino-Indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same KAOHSIUNG MEDICAL UNIVERSITY (TW) 2009-04-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190119210-A1 AROMATIC SULFONAMIDE DERIVATIVES ARSA, SULT2A1, TPST2 ABCB11 75/4885PTGS1 2580/4885PTGS2 2521/4885
US-20220324807-A1 AROMATIC SULFONAMIDE DERIVATIVES ARSA, SULT2A1, TPST2 ABCB11 75/4885PTGS1 2580/4885PTGS2 2521/4885
US-20090111987-A1 Imino-Indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same IMPA1, IMPDH1, IPO5 ABCB11 117/4885PTGS1 1518/4885PTGS2 2216/4885
US-11524938-B2 Aromatic sulfonamide derivatives ARSA, SULT2A1, TPST2 ABCB11 75/4885PTGS1 2580/4885PTGS2 2521/4885
US-10844016-B2 Aromatic sulfonamide derivatives ARSA, SULT2A1, TPST2 ABCB11 75/4885PTGS1 2580/4885PTGS2 2521/4885
US-20230118751-A1 FUSED RING COMPOUND AND APPLICATION THEREOF P2RX4, P2RX3, P2RX2 ABCB11 302/4885PTGS1 866/4885PTGS2 1403/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.