Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 1/20 | 1.00 |
| ▸ | APP | P05067 | 1/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.53 |
| ▸ | HTR2B | P41595 | 3/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.53 |
| ▸ | HTR3B | O95264 | 1/20 | 0.53 |
| ▸ | HTR3A | P46098 | 1/20 | 0.53 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.53 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29502102 | 1.00 | HTR2C (1.00) | HTR2CADRB2APPSLC6A4KDM4E | |
| Hydrochloric Acid SCHEMBL31285949 | 0.98 | HTR2C (1.00) | HTR2CADRB2APPSLC6A4KDM4E | |
| Hydrochloric Acid SCHEMBL893070 | 0.98 | HTR2C (1.00) | HTR2CADRB2APPSLC6A4KDM4E | |
| Methane SCHEMBL10788775 | 0.98 | HTR2C (0.97) | HTR2CADRB2APPSLC6A4KDM4E | |
| SCHEMBL1445576 | 0.90 | HTR2C (0.81) | HTR2CADRB2APPSLC6A4KDM4E | |
| SCHEMBL30279603 | 0.90 | HTR2C (0.81) | HTR2CADRB2APPSLC6A4KDM4E | |
| SCHEMBL734917 | 0.89 | HTR2C (0.79) | HTR2CADRB2SLC6A4KDM4EATM | |
| SCHEMBL807343 | 0.85 | HTR2C (0.74) | HTR2CADRB2KDM4EATMBRD4 | |
| SCHEMBL28594057 | 0.85 | HTR2C (0.74) | HTR2CADRB2KDM4EATMBRD4 | |
| Tert-Butyl Formate SCHEMBL28799577 | 0.84 | HTR2C (0.70) | HTR2CADRB2APPSLC6A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 509 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048513-A1 | Novel inhibitors of chymase | HAWKINS MICHAEL J | 2010-02-25 | — | — | US | claimed |
| US-7459444-B2 | Inhibitors of chymase | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-12-02 | — | — | US | claimed |
| US-20050176769-A1 | Novel inhibitors of chymase | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-08-11 | — | — | US | claimed |
| EP-0070053-B1 | NOVEL BICYCLIC PYRIMIDIN-5-ONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-04-16 | — | — | EP | claimed |
| EP-0177087-A2 | 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-04-09 | — | — | EP | claimed |
| EP-0058975-B1 | SUBSTITUTED N-(4-INDOLYL-PIPERIDINO-ALKYL) BENZIMIDAZOLONES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL PREPARATIONS | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1984-12-12 | — | — | EP | claimed |
| EP-0070053-A2 | Novel bicyclic pyrimidin-5-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-01-19 | — | — | EP | claimed |
| EP-0058975-A1 | Substituted N-(4-indolyl-piperidino-alkyl) benzimidazolones, processes for their preparation and their use as pharmaceutical preparations | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1982-09-01 | — | — | EP | claimed |
| US-3993764-A | 3-(4*-PIPERIDYL)-INDOLES | ROUSSEL-UCLAF (FR) | 1976-11-23 | — | — | US | claimed |
| JP-6073011-A | — | — | None | — | — | JP | disclosed |
| US-20250034106-A1 | 3-CYCLOAMINO-INDOLE COMPOUNDS AS SEROTONERGIC AGENTS USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | MINDSET PHARMA INC. (CA) | 2025-01-30 | — | — | US | disclosed |
| US-20240383850-A1 | INDOLE DERIVATIVES AS SEROTONERGIC AGENTS USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | MINDSET PHARMA INC. (CA) | 2024-11-21 | — | — | US | disclosed |
| US-20240376052-A1 | N-SUBSTITUTED INDOLE DERIVATIVES AS SEROTONERGIC AGENTS USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | MINDSET PHARMA INC. (CA) | 2024-11-14 | — | — | US | disclosed |
| US-20240067631-A1 | PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS | CYTOKINETICS, INC. | 2024-02-29 | — | — | US | disclosed |
| US-3993764-A | 3-(4*-PIPERIDYL)-INDOLES | ROUSSEL-UCLAF (FR) | 1976-11-23 | — | — | US | disclosed |
| US-3988453-A | Novel phenothiazines as neuroleptics | ROUSSEL-UCLAF (FR) | 1976-10-26 | — | — | US | disclosed |
| US-3980658-A | SEDATIVES, TRANQUILIZERS | BOEHRINGER INGELHEIM GMBH (DT) | 1976-09-14 | — | — | US | disclosed |
| US-3950527-A | SEDATIVES | ROUSSEL-UCLAF (FR) | 1976-04-13 | — | — | US | disclosed |
| US-3947578-A | Omega-[4-(3\"-indolyl)-piperidino]-alkyl-arylketones as nevroleptics | ROUSSEL UCLAF (FR) | 1976-03-30 | — | — | US | disclosed |
| JP-H00673011-A | — | — | 0001-01-01 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240376052-A1 | N-SUBSTITUTED INDOLE DERIVATIVES AS SEROTONERGIC AGENTS USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | TPH1, HTR5A, TPH2 | HTR2C 8/4885ADRB2 94/4885APP 1276/4885 |
| US-20100048513-A1 | Novel inhibitors of chymase | CMA1, SERPINB1, TPSAB1 | HTR2C 3442/4885ADRB2 2638/4885APP 456/4885 |
| US-20050176769-A1 | Novel inhibitors of chymase | CMA1, SERPINB1, TPSAB1 | HTR2C 3442/4885ADRB2 2638/4885APP 456/4885 |
| US-20240383850-A1 | INDOLE DERIVATIVES AS SEROTONERGIC AGENTS USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | TPH1, HTR5A, TPH2 | HTR2C 8/4885ADRB2 98/4885APP 1269/4885 |
| US-20240067631-A1 | PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS | NAMPT, NNT, NAPRT | HTR2C 3782/4885ADRB2 1336/4885APP 2845/4885 |
| US-20250034106-A1 | 3-CYCLOAMINO-INDOLE COMPOUNDS AS SEROTONERGIC AGENTS USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | TPH1, HTR3A, HTR1A | HTR2C 7/4885ADRB2 114/4885APP 467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.