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SCHEMBL3764060

SCHEMBL3764060

COC(=O)C1=C(Cl)/C(=N/OS(C)(=O)=O)CC(c2ccc(Cl)cc2)N1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SLC6A3 Q01959 5/20 0.38
▸ HPGD P15428 3/20 0.38
▸ KDM4E B2RXH2 2/20 0.38
▸ ALDH1A1 P00352 2/20 0.38
▸ GLA P06280 1/20 0.38
▸ POLB P06746 1/20 0.38
▸ GAA P10253 1/20 0.38
▸ CASP1 P29466 1/20 0.38
▸ CASP7 P55210 1/20 0.38
▸ HSD17B10 Q99714 1/20 0.38
▸ LMNA P02545 1/20 0.37
▸ GPBAR1 Q8TDU6 1/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.34
▸ KMT2A Q03164 1/20 0.33
▸ CACNA1F O60840 1/20 0.32
▸ CACNA1D Q01668 1/20 0.32
▸ CACNA1S Q13698 1/20 0.32
▸ CACNA1C Q13936 1/20 0.32
▸ CA1 P00915 2/20 0.31
▸ CA2 P00918 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3764062 1.00 SLC6A3 (0.38) SLC6A3HPGDKDM4EALDH1A1GLA
SCHEMBL14353834 1.00 SLC6A3 (0.38) SLC6A3HPGDKDM4EALDH1A1GLA
SCHEMBL3768503 0.89 ABCC1 (0.41) HPGDKDM4EALDH1A1GAALMNA
SCHEMBL3768505 0.89 ABCC1 (0.41) HPGDKDM4EALDH1A1GAALMNA
SCHEMBL1705575 0.78 SLC6A3 (0.38) SLC6A3HPGDKDM4EALDH1A1GLA
SCHEMBL3763795 0.78 SLC6A3 (0.38) SLC6A3HPGDKDM4EALDH1A1GLA
SCHEMBL14354266 0.78 MEP1B (0.31) SLC6A3
SCHEMBL1706143 0.78 MEP1B (0.31) SLC6A3
SCHEMBL15121579 0.71 PTGS2 (0.31) SLC6A3ALDH1A1GAA
SCHEMBL15121580 0.71 PTGS2 (0.31) SLC6A3ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2725903-B1 3-ALKOXY, THIOALKYL AND AMINO-4-AMINO-6-(SUBSTITUTED)PICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2020-04-15 — — EP disclosed
US-9518018-B2 3-alkoxy, thioalkyl and amino-4-amino-6-(substituted)picolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2016-12-13 — — US disclosed
US-20150133301-A1 3-ALKOXY, THIOALKYL AND AMINO-4-AMINO-6-(SUBSTITUTED)PICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2015-05-14 — — US disclosed
EP-2440526-B1 3-HALO-6-(ARLY)-4-IMINOTETRAHYDROPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2014-11-12 — — EP disclosed
EP-2440526-B1 3-HALO-6-(ARLY)-4-IMINOTETRAHYDROPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2014-11-12 — — EP disclosed
US-8754229-B2 3-alkoxy, thioalkyl and amino-4-amino-6-(substituted)picolinates and their use as herbicides DOW AGROSCIENCES, LLC. (US) 2014-06-17 — — US disclosed
EP-2725903-A1 3-ALKOXY, THIOALKYL AND AMINO-4-AMINO-6-(SUBSTITUTED)PICOLINATES AND THEIR USE AS HERBICIDES Dow AgroSciences LLC (US) 2014-05-07 — — EP disclosed
US-8598086-B2 3-halo-(arly)-4-iminotetrahydropicolinates and their use as herbicides DOW AGROSCIENCES, LLC. (US) 2013-12-03 — — US disclosed
EP-2440530-B1 PROCESS FOR THE PREPARATION OF 6-(ARYL)-4-AMINOPICOLINATES DOW AGROSCIENCES LLC (US) 2013-07-24 — — EP disclosed
EP-2440530-B1 PROCESS FOR THE PREPARATION OF 6-(ARYL)-4-AMINOPICOLINATES DOW AGROSCIENCES LLC (US) 2013-07-24 — — EP disclosed
US-8252938-B2 Process for the preparation of 6-(aryl)-4-aminopicolinates DOW AGROSCIENCES, LLC. (US) 2012-08-28 — — US disclosed
US-8252938-B2 Process for the preparation of 6-(aryl)-4-aminopicolinates DOW AGROSCIENCES, LLC. (US) 2012-08-28 — — US disclosed
WO-2010144380-A1 PROCESS FOR THE PREPARATION OF 6-(ARYL)-4-AMINOPICOLINATES DOW AGROSCIENCES LLC (US) 2010-12-16 — — WO disclosed
WO-2010144379-A1 3-HALO-(ARLY)-4-IMINOTETRAHYDROPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2010-12-16 — — WO disclosed
US-20100311594-A1 3-HALO-(ARLY)-4-IMINOTETRAHYDROPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2010-12-09 — — US disclosed
US-20100311594-A1 3-HALO-(ARLY)-4-IMINOTETRAHYDROPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2010-12-09 — — US disclosed
US-20100311594-A1 3-HALO-(ARLY)-4-IMINOTETRAHYDROPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2010-12-09 — — US disclosed
US-20100311981-A1 PROCESS FOR THE PREPARATION OF 6-(ARYL)-4-AMINOPICOLINATES DOW AGROSCIENCES LLC (US) 2010-12-09 — — US disclosed
US-20100311981-A1 PROCESS FOR THE PREPARATION OF 6-(ARYL)-4-AMINOPICOLINATES DOW AGROSCIENCES LLC (US) 2010-12-09 — — US disclosed
US-20100311981-A1 PROCESS FOR THE PREPARATION OF 6-(ARYL)-4-AMINOPICOLINATES DOW AGROSCIENCES LLC (US) 2010-12-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150133301-A1 3-ALKOXY, THIOALKYL AND AMINO-4-AMINO-6-(SUBSTITUTED)PICOLINATES AND THEIR USE AS HERBICIDES DDT, AADAC, AADAT SLC6A3 116/4885HPGD 4513/4885KDM4E 1083/4885
US-20100311981-A1 PROCESS FOR THE PREPARATION OF 6-(ARYL)-4-AMINOPICOLINATES HTR6, CYP46A1, NISCH SLC6A3 223/4885HPGD 1088/4885KDM4E 2875/4885
US-20100311594-A1 3-HALO-(ARLY)-4-IMINOTETRAHYDROPICOLINATES AND THEIR USE AS HERBICIDES HDHD5, ATL3, HCAR3 SLC6A3 33/4885HPGD 2956/4885KDM4E 3033/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.