Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1219538 | 0.83 | NPC1 (0.53) | NR1H4CASP3NPC1RAB9AMEN1 | |
| SCHEMBL3979477 | 0.80 | LMNA (0.43) | NR1H4NPC1RAB9AMEN1KMT2A | |
| SCHEMBL3771469 | 0.80 | LMNA (0.43) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14755751 | 0.79 | RAB9A (0.49) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL930343 | 0.79 | ADORA3 (0.59) | NR1H4CASP3NPC1RAB9AMEN1 | |
| SCHEMBL12112411 | 0.79 | ADORA3 (0.44) | NR1H4NPC1RAB9AMEN1KMT2A | |
| SCHEMBL14755837 | 0.78 | ALDH1A1 (0.51) | CASP3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL14488175 | 0.78 | ADORA3 (0.42) | CASP3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL31120311 | 0.78 | CYP19A1 (0.66) | NPC1RAB9ASMN1; SMN2LMNARXFP1 | |
| SCHEMBL3761164 | 0.78 | MAPT (0.62) | NPC1RAB9ASMN1; SMN2LMNAADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9023852-B2 | 1, 2, 4-thiadiazol-5-ylpiperazine derivatives useful in the treatment of neurodegenerative diseases | REMYND NV (BE) | 2015-05-05 | — | — | US | disclosed |
| EP-2726470-B1 | 1,2,4-THIADIAZOL-5-YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | REMYND NV (BE) | 2015-04-29 | — | — | EP | disclosed |
| US-20140128404-A1 | 1, 2, 4-Thiadiazol-5-Ylpiperazine derivatives useful in the treatment of neurodegenerative diseases | REMYND NV (BE) | 2014-05-08 | — | — | US | disclosed |
| EP-2726470-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | reMynd NV (BE) | 2014-05-07 | — | — | EP | disclosed |
| WO-2013031694-A1 | AMINE COMPOUND AND SALT THEREOF | 富山化学工業株式会社 (JP) | 2013-03-07 | — | — | WO | disclosed |
| WO-2013004642-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | REMYND NV (BE) | 2013-01-10 | — | — | WO | disclosed |
| US-7851473-B2 | Amide compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-14 | — | — | US | disclosed |
| US-20080312226-A1 | Amide Compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-18 | — | — | US | disclosed |
| EP-1813606-A1 | AMIDE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2007-08-01 | — | — | EP | disclosed |
| US-6380187-B2 | FUNGICIDES | YU DINGWEI TIM (US) | 2002-04-30 | — | — | US | disclosed |
| US-20020002193-A1 | Thiadiazole antifungal agents | YU DINGWEI TIM (US) | 2002-01-03 | — | — | US | disclosed |
| US-6281217-B2 | ANTIFUNGAL ACTIVITY AGAINST A VARIETY OF FUNGI INCLUDING STRAINS WHICH HAVE PROVEN TO BE RESISTANT TO TREATMENT WITH KNOWN ANTIFUNGAL AGENTS SUCH AS FLUCONAZOLE. | YU DINGWEI TIM (US) | 2001-08-28 | — | — | US | disclosed |
| US-6277873-B1 | CONTROLLING DRUG RESISTANT FUNGI | YU DINGWEI TIM (US) | 2001-08-21 | — | — | US | disclosed |
| US-20010000512-A1 | Novel class of piperazino substituted thiazoles | YU DINGWEI TIM (US) | 2001-04-26 | — | — | US | disclosed |
| US-20010000177-A1 | Novel class of thiomorpholino substituted thiazoles | YU DINGWEI TIM (US) | 2001-04-05 | — | — | US | disclosed |
| US-20010000178-A1 | PYRIDYL SUBSTITUTED THIAZOLES | YU DINGWEI TIM (US) | 2001-04-05 | — | — | US | disclosed |
| US-6156776-A | Diaryl substituted thiazoles useful in the treatment of fungal infections | YU DINGWEI TIM (US) | 2000-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010000177-A1 | Novel class of thiomorpholino substituted thiazoles | THUMPD1, ERG28, THOC2 | NR1H4 2796/4885CASP3 2032/4885NPC1 1178/4885 |
| US-20080312226-A1 | Amide Compound | FAAH, FAAH2, CNR2 | NR1H4 332/4885CASP3 1982/4885NPC1 1078/4885 |
| US-20140128404-A1 | 1, 2, 4-Thiadiazol-5-Ylpiperazine derivatives useful in the treatment of neurodegenerative diseases | MAPT, PSEN1, PSEN2 | NR1H4 4192/4885CASP3 363/4885NPC1 389/4885 |
| US-20020002193-A1 | Thiadiazole antifungal agents | ERG28, NAT1, AADAC | NR1H4 3294/4885CASP3 855/4885NPC1 763/4885 |
| US-20010000512-A1 | Novel class of piperazino substituted thiazoles | ERG28, DPM1, NAT1 | NR1H4 3829/4885CASP3 788/4885NPC1 835/4885 |
| US-20010000178-A1 | PYRIDYL SUBSTITUTED THIAZOLES | PDXK, OXA1L, ERG28 | NR1H4 3291/4885CASP3 699/4885NPC1 1114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.