Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.48 |
| ▸ | BRD1 | O95696 | 1/20 | 0.48 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | PKLR | P30613 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29156174 | 0.91 | PKM (0.54) | KEAP1NFE2L2HTR2CHTR2BATM | |
| SCHEMBL12596097 | 0.83 | TRIM24 (0.51) | KEAP1NFE2L2TRIM24BRD1BRPF1 | |
| SCHEMBL5747283 | 0.80 | PKM (0.49) | KEAP1NFE2L2TRIM24BRD1BRPF1 | |
| SCHEMBL6674134 | 0.80 | CA2 (0.59) | KEAP1NFE2L2TRIM24BRD1BRPF1 | |
| SCHEMBL6307961 | 0.80 | KEAP1 (0.51) | KEAP1NFE2L2TRIM24BRD1BRPF1 | |
| SCHEMBL27898021 | 0.78 | PTGS2 (0.52) | KEAP1NFE2L2TRIM24BRD1BRPF1 | |
| SCHEMBL8533151 | 0.74 | KEAP1 (0.47) | KEAP1NFE2L2TRIM24BRD1BRPF1 | |
| SCHEMBL8533154 | 0.74 | KEAP1 (0.47) | KEAP1NFE2L2TRIM24BRD1BRPF1 | |
| SCHEMBL8164691 | 0.72 | PKM (0.57) | KEAP1NFE2L2PKMPKLRMAPT | |
| SCHEMBL12355593 | 0.72 | ALDH1A1 (0.74) | KEAP1NFE2L2MAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234486-A1 | BENZIMIDAZOLES AND ANALOGS AS RHO KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079011-A1 | BENZIMIDAZOLES AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-06-25 | — | — | WO | disclosed |