Sugi Predict

Sugi Predict / Compounds / SCHEMBL377648

SCHEMBL377648

SCHEMBL377648

CC(=O)N1CCN(c2ccc(C=O)cc2)CC1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GFER P55789 3/20 0.65
▸ CASP6 P55212 1/20 0.65
▸ ALDH1A1 P00352 6/20 0.64
▸ MAPT P10636 7/20 0.59
▸ MEN1 O00255 2/20 0.59
▸ KMT2A Q03164 2/20 0.59
▸ TRIM24 O15164 1/20 0.59
▸ TRIM33 Q9UPN9 1/20 0.59
▸ KDM4E B2RXH2 3/20 0.58
▸ SMN1; SMN2 Q16637 2/20 0.58
▸ NPC1 O15118 1/20 0.51
▸ RAB9A P51151 1/20 0.51
▸ CYP17A1 P05093 3/20 0.51
▸ CYP21A2 P08686 3/20 0.51
▸ CYP11B1 P15538 3/20 0.51
▸ GAA P10253 3/20 0.50
▸ ALOX15 P16050 3/20 0.50
▸ ALOX12 P18054 3/20 0.50
▸ MAPK1 P28482 3/20 0.50
▸ CYP2C9 P11712 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL378044 0.94 TRIM24 (0.62) GFERCASP6ALDH1A1MAPTMEN1
SCHEMBL17923025 0.86 GFER (0.65) GFERCASP6ALDH1A1MAPTMEN1
SCHEMBL4756395 0.84 TRIM24 (0.61) GFERCASP6ALDH1A1MAPTMEN1
SCHEMBL3077544 0.83 TRIM24 (0.83) ALDH1A1TRIM24TRIM33KDM4ESMN1; SMN2
SCHEMBL2561698 0.83 TRIM24 (0.83) ALDH1A1TRIM24TRIM33KDM4ESMN1; SMN2
SCHEMBL28690259 0.82 ALDH1A1 (0.58) GFERCASP6ALDH1A1MAPTMEN1
SCHEMBL25160096 0.81 ALDH1A1 (0.57) GFERCASP6ALDH1A1MAPTMEN1
SCHEMBL82046 0.80 GFER (0.71) GFERCASP6ALDH1A1MAPTMEN1
SCHEMBL1128293 0.80 GFER (0.71) GFERCASP6ALDH1A1MAPTMEN1
SCHEMBL10366199 0.80 MAPT (0.71) ALDH1A1MAPTTRIM24TRIM33KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2408454-B1 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP (CA) 2024-07-24 — — EP disclosed
EP-3694977-B1 LEUCO COLORANTS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS PROCTER & GAMBLE (US) 2023-11-01 — — EP disclosed
EP-3694977-B1 LEUCO COLORANTS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS PROCTER & GAMBLE (US) 2023-11-01 — — EP disclosed
US-11660303-B2 2-phenylimidazo[4,5-b]pyridin-7-amine derivates useful as inhibitors of mammalian tyrosine kinase ROR1 activity KANCERA AB (SE) 2023-05-30 — — US disclosed
US-11407719-B2 Anti-inflammatory agents RESVERLOGIX CORP. (CA) 2022-08-09 — — US disclosed
CN-111465658-B Leuco compounds 美利肯公司 2022-07-05 — — CN disclosed
US-11236235-B2 Leuco compounds MILLIKEN & COMPANY (US) 2022-02-01 — — US disclosed
US-11236235-B2 Leuco compounds MILLIKEN & COMPANY (US) 2022-02-01 — — US disclosed
EP-3481824-B1 2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY KANCERA AB (SE) 2021-10-20 — — EP disclosed
CN-109563092-B 2-phenylimidazo [4,5-B ] pyridin-7-amine derivatives useful as inhibitors of the activity of the mammalian tyrosine kinase ROR1 坎塞拉有限公司 2021-09-14 — — CN disclosed
US-20130190288-A1 BENZYL SULFONAMIDE DERIVATIVES AS RORC MODULATORS GENENTECH, INC. (US) 2013-07-25 — — US disclosed
WO-2013092941-A1 BENZYL SULFONAMIDE DERIVATIVES AS RORc MODULATORS F. HOFFMANN-LA ROCHE AG (CH) 2013-06-27 — — WO disclosed
WO-2013092941-A1 BENZYL SULFONAMIDE DERIVATIVES AS RORc MODULATORS F. HOFFMANN-LA ROCHE AG (CH) 2013-06-27 — — WO disclosed
US-20120316178-A1 PIPERAZINES AS ANTIMALARIAL AGENTS IDORSIA PHARMACEUTICALS LTD (CH) 2012-12-13 — — US disclosed
US-20120316178-A1 PIPERAZINES AS ANTIMALARIAL AGENTS IDORSIA PHARMACEUTICALS LTD (CH) 2012-12-13 — — US disclosed
US-20120040954-A1 NOVEL ANTI-INFLAMMATORY AGENTS HEPALINK (HONG KONG) LIMITED (HK) 2012-02-16 — — US disclosed
EP-2408454-A2 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP. (CA) 2012-01-25 — — EP disclosed
WO-2011083413-A1 PIPERAZINES AS ANTIMALARIAL AGENTS ACTELION PHARMACEUTICALS LTD (CH) 2011-07-14 — — WO disclosed
WO-2010106436-A2 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP. (CA) 2010-09-23 — — WO disclosed
US-20080004415-A1 Non-linear optically active molecules, their synthesis, and use OPTIMER PHOTONICS, INC. (US) 2008-01-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11407719-B2 Anti-inflammatory agents VCAM1, ICAM1, IL6 GFER 2109/4885CASP6 29/4885ALDH1A1 587/4885
US-20130190288-A1 BENZYL SULFONAMIDE DERIVATIVES AS RORC MODULATORS RORA, RORC, RORB GFER 3478/4885CASP6 3085/4885ALDH1A1 1026/4885
US-20120316178-A1 PIPERAZINES AS ANTIMALARIAL AGENTS ITPA, PAK5, THPO GFER 4021/4885CASP6 2105/4885ALDH1A1 1765/4885
US-20080004415-A1 Non-linear optically active molecules, their synthesis, and use INCENP, CYBA, PAICS GFER 2694/4885CASP6 3573/4885ALDH1A1 378/4885
US-11660303-B2 2-phenylimidazo[4,5-b]pyridin-7-amine derivates useful as inhibitors of mammalian tyrosine kinase ROR1 activity ROR1, RORB, RORA GFER 4802/4885CASP6 4569/4885ALDH1A1 245/4885
US-20120040954-A1 NOVEL ANTI-INFLAMMATORY AGENTS VCAM1, ICAM1, IL6 GFER 1994/4885CASP6 30/4885ALDH1A1 650/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.