SCHEMBL379033

SCHEMBL379033

C#CCN1C(=O)C=CC1=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.47
MAOB P27338 1/20 0.47
MGLL Q99685 10/20 0.46
FAAH O00519 4/20 0.46
ALDH1A1 P00352 3/20 0.46
LMNA P02545 2/20 0.46
MAPT P10636 2/20 0.46
NPSR1 Q6W5P4 2/20 0.46
BLM P54132 2/20 0.46
GMNN O75496 1/20 0.46
THPO P40225 1/20 0.46
PMP22 Q01453 1/20 0.46
HPGD P15428 2/20 0.44
HSP90AA1 P07900 1/20 0.44
TLR9 Q9NR96 1/20 0.44
TP53 P04637 1/20 0.44
PKM P14618 1/20 0.44
XBP1 P17861 1/20 0.44
MAPK1 P28482 1/20 0.44
HTT P42858 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15783238 0.84 MAOA (0.41) MAOAMAOBMGLLFAAHALDH1A1
SCHEMBL2639486 0.78 MGLL (0.50) MGLLFAAHALDH1A1LMNAMAPT
SCHEMBL14587456 0.75 MGLL (0.54) MGLLFAAHALDH1A1LMNAMAPT
SCHEMBL10699322 0.74 MGLL (0.46) MGLLFAAHALDH1A1LMNAMAPT
SCHEMBL797328 0.72 MGLL (0.62) MGLLFAAHALDH1A1LMNAMAPT
SCHEMBL23246173 0.70 MAOA (0.37) MAOAMAOBTP53AMY1ACYP19A1
SCHEMBL17070868 0.70 MGLL (0.48) MGLLFAAHALDH1A1LMNAMAPT
SCHEMBL7560300 0.69
SCHEMBL16307837 0.69 RGS4 (0.49) MAOAMAOBAMY1A
SCHEMBL17629426 0.68 MGLL (0.59) MGLLFAAHALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 302 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12116603-B2 RNA silencing nanozymes UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2024-10-15 US claimed
CN-116392580-A Type 1 diabetes multi-antigen vaccine preparation and application thereof 中国科学技术大学 2023-07-07 CN claimed
CN-115598340-A Detection method for ultrasensitive fluorescence counting immunoassay by using biological orthogonal reaction immobilized bacteria 南京大学(CN) 2023-01-13 CN claimed
EP-4045088-A1 METHOD FOR THE PREPARATION OF POLYMERIC CARRIERS FOR PH- CONTROLLED DRUG RELEASE AND THEIR CONJUGATES WITH DRUGS Ustav Makromolekularni Chemie AV CR, v.v.i. (CZ) 2022-08-24 EP claimed
WO-2022093792-A1 ELECTROLYTE ADDITIVES CONTAINING ONE, TWO, OR MORE TRIPLE-BONDED MOIETIES FOR SILICON ANODE-BASED BATTERIES ENEVATE CORPORATION (US) 2022-05-05 WO claimed
US-20220131195-A1 ELECTROLYTE ADDITIVES CONTAINING ONE, TWO, OR MORE TRIPLE-BONDED MOIETIES FOR SILICON ANODE-BASED LI-ION BATTERIES ENEVATE CORPORATION 2022-04-28 US claimed
US-20200388885-A1 SILICON-BASED ENERGY STORAGE DEVICES WITH LIPO2F2 SALT-CONTAINING ELECTROLYTE FORMULATIONS ENEVATE CORPORATION 2020-12-10 US claimed
EP-0850920-B1 Ionic conductive materials comprising salts of perfluorinated amides and uses thereof CENTRE NAT RECH SCIENT (FR) 2002-09-11 EP claimed
US-12269797-B2 Bifunctional linker for bisconjugation, method of synthesis, and method of use THE JOHNS HOPKINS UNIVERSITY (US) 2025-04-08 US disclosed
US-20250064964-A1 ANTIBODY DRUG CONJUGATES FOR ABLATING HEMATOPOIETIC STEM CELLS NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC. DBA GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION (GNF) 2025-02-27 US disclosed
CN-115192732-B DNA toxic dimer compound and conjugate thereof 成都百利多特生物药业有限责任公司 2025-02-18 CN disclosed
US-12171839-B2 Antibody drug conjugates for ablating hematopoietic stem cells NOVARTIS AG (CH) 2024-12-24 US disclosed
US-20240390508-A1 HUMAN TRANSFERRIN RECEPTOR BINDING PEPTIDE-DRUG CONJUGATE TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2024-11-28 US disclosed
US-12115261-B2 Block copolymer comprising hydrophilic first block, hydrophobic second block, and functional group capable of specifically binding to thiol GI CELL, INC. (KR) 2024-10-15 US disclosed
US-7179907-B2 Antibiotic compounds SOMALOGIC OPERATING CO. INC. 2007-02-20 US disclosed
WO-2007018431-A2 TRIAZOLE-CONTAINING RELEASABLE LINKERS AND CONJUGATES COMPRISING THE SAME SYNTARGA B.V. (NL) 2007-02-15 WO disclosed
EP-0850920-B1 Ionic conductive materials comprising salts of perfluorinated amides and uses thereof CENTRE NAT RECH SCIENT (FR) 2002-09-11 EP disclosed
EP-0946648-B1 HARDENABLE ORGANOSILOXANE PRODUCTS WACKER CHEMIE GMBH (DE) 2000-07-05 EP disclosed
EP-0946648-A1 HARDENABLE ORGANOSILOXANE PRODUCTS Wacker-Chemie GmbH (DE) 1999-10-06 EP disclosed
WO-1998027163-A1 HARDENABLE ORGANOSILOXANE PRODUCTS WACKER-CHEMIE GMBH (DE) 1998-06-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250064964-A1 ANTIBODY DRUG CONJUGATES FOR ABLATING HEMATOPOIETIC STEM CELLS ABL1, BCR, CD47 MAOA 4348/4885MAOB 4339/4885MGLL 4860/4885
US-12269797-B2 Bifunctional linker for bisconjugation, method of synthesis, and method of use C1R, C9, FCGRT MAOA 1657/4885MAOB 1572/4885MGLL 4558/4885
US-20240390508-A1 HUMAN TRANSFERRIN RECEPTOR BINDING PEPTIDE-DRUG CONJUGATE MUSK, TFRC, SLC7A1 MAOA 4624/4885MAOB 4069/4885MGLL 4852/4885
US-20220131195-A1 ELECTROLYTE ADDITIVES CONTAINING ONE, TWO, OR MORE TRIPLE-BONDED MOIETIES FOR SILICON ANODE-BASED LI-ION BATTERIES SELENOI, SIK1, SIK2 MAOA 2197/4885MAOB 2710/4885MGLL 3026/4885
US-12171839-B2 Antibody drug conjugates for ablating hematopoietic stem cells BCR, ABL1, CD47 MAOA 4253/4885MAOB 4257/4885MGLL 4849/4885
US-12115261-B2 Block copolymer comprising hydrophilic first block, hydrophobic second block, and functional group capable of specifically binding to thiol TBCB, HSPA1B, FGB MAOA 3626/4885MAOB 590/4885MGLL 2552/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.