SCHEMBL3799586

SCHEMBL3799586

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nearest known ligand 0.40

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CA1 known ✓ P00915 2/20 0.32
CA4 known ✓ P22748 2/20 0.32
LMNA P02545 4/20 0.40
SLC34A1 Q06495 1/20 0.39
KDM4E B2RXH2 1/20 0.33
CYP2C19 P33261 1/20 0.33
KMT2A Q03164 1/20 0.33
CA5A P35218 2/20 0.32
CA5B Q9Y2D0 2/20 0.32
BLM P54132 1/20 0.30
PMP22 Q01453 1/20 0.30
CYP2C9 P11712 1/20 0.30
TSHR P16473 1/20 0.30
ALOX12 P18054 1/20 0.30
NFKB1 P19838 1/20 0.30
MAPK1 P28482 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9138380 1.00 LMNA (0.40) LMNASLC34A1KDM4ECYP2C19KMT2A
SCHEMBL1615261 1.00 LMNA (0.40) LMNASLC34A1KDM4ECYP2C19KMT2A
SCHEMBL30537706 1.00 LMNA (0.40) LMNASLC34A1KDM4ECYP2C19KMT2A
Sodium Monofluorophosphate SCHEMBL93758 1.00
SCHEMBL16758689 1.00 LMNA (0.40) LMNASLC34A1KDM4ECYP2C19KMT2A
SCHEMBL23497802 0.95 LMNA (0.38) LMNASLC34A1KDM4ECYP2C19KMT2A
SCHEMBL14120113 0.95 LMNA (0.38) LMNASLC34A1KDM4ECYP2C19KMT2A
Ammonia Solution, Strong SCHEMBL2892188 0.95
SCHEMBL9816086 0.95 LMNA (0.38) LMNASLC34A1KDM4ECYP2C19KMT2A
SCHEMBL8720488 0.95 LMNA (0.38) LMNASLC34A1KDM4ECYP2C19KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4037778-A1 ORAL CARE COMPOSITIONS COMPRISING HOPS BETA ACID AND FLUORIDE The Procter & Gamble Company (US) 2022-08-10 EP disclosed
WO-2021067993-A1 ORAL CARE COMPOSITIONS COMPRISING HOPS BETA ACID AND FLUORIDE THE PROCTER & GAMBLE COMPANY (US) 2021-04-08 WO disclosed
US-10576032-B2 Oral care composition comprising serine and at least a zinc salt COLGATE-PALMOLIVE COMPANY (US) 2020-03-03 US disclosed
US-20160317409-A1 ORAL CARE COMPOSITION COMPRISING SERINE AND AT LEAST A ZINC SALT COLGATE-PALMOLIVE COMPANY (US) 2016-11-03 US disclosed
US-20100330002-A1 COMPOSITIONS AND METHODS COMPRISING BASIC AMINO ACID PEPTIDES AND PROTEASES COLGATE-PALMOLIVE COMPANY (US) 2010-12-30 US disclosed
US-20100322873-A1 BEVERAGE COMPRISING ARGININE COLGATE-PALMOLIVE COMPANY (US) 2010-12-23 US disclosed
EP-0446753-B1 Therapeutic compositions with controlled release of medicaments supported on crosslinked polymers and coated with polymer films and their preparation process VECTORPHARMA INT (IT) 1994-11-23 EP disclosed