Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7583928 | 0.80 | TAS1R3 (0.51) | CA1CA14EGFRLMNAL3MBTL1 | |
| SCHEMBL6855348 | 0.79 | KMT2A (0.43) | HPGDLMNAL3MBTL1POLBKMT2A | |
| SCHEMBL3809482 | 0.78 | KMT2A (0.45) | EGFRL3MBTL1POLBKMT2APKM | |
| SCHEMBL3812077 | 0.77 | POLB (0.47) | LMNAL3MBTL1POLBKMT2APKM | |
| SCHEMBL27567255 | 0.74 | CRHR1 (0.39) | HPGDPOLBKMT2APKMKDM4E | |
| SCHEMBL27567249 | 0.74 | SMN1; SMN2 (0.43) | LMNAL3MBTL1POLBKMT2APKM | |
| SCHEMBL27567439 | 0.71 | LMNA (0.39) | LMNAPOLBKMT2AKDM4ENPSR1 | |
| SCHEMBL4774956 | 0.71 | CA1 (0.54) | CA1CA14EGFRHPGDLMNA | |
| SCHEMBL4774951 | 0.71 | CA1 (0.54) | CA1CA14EGFRHPGDLMNA | |
| SCHEMBL3809982 | 0.71 | CA1 (0.42) | CA1CA14EGFRHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341786-B9 | SUBSTITUTED DERIVATIVES OF AMINOFURAN-2-YL-ACETIC ACID AND AMINOTHIEN-2-YL-ACETIC ACID AND THE USE THEREOF FOR TREATING MIGRAINES AND PAIN | GRUENENTHAL GMBH (DE) | 2009-08-05 | — | — | EP | claimed |
| EP-1341786-B1 | SUBSTITUTED DERIVATIVES OF AMINOFURAN-2-YL-ACETIC ACID AND AMINOTHIEN-2-YL-ACETIC ACID AND THE USE THEREOF FOR TREATING MIGRAINES AND PAIN | GRUENENTHAL GMBH (DE) | 2008-12-24 | — | — | EP | claimed |
| US-6797712-B2 | Substituted amino-furan-2-yl-acetic acid and amino-thien-2-yl-acetic acid derivatives and their use in the treatment of migraine and pain | GRUENENTHAL GMBH (DE) | 2004-09-28 | — | — | US | claimed |
| US-20040030156-A1 | Substituted amino-furan-2-yl-acetic acid and amino-thien-2-yl-acetic acid derivatives and their use in the treatment of migraine and pain | GRUENENTHAL GMBH (DE) | 2004-02-12 | — | — | US | claimed |
| EP-1341786-B9 | SUBSTITUTED DERIVATIVES OF AMINOFURAN-2-YL-ACETIC ACID AND AMINOTHIEN-2-YL-ACETIC ACID AND THE USE THEREOF FOR TREATING MIGRAINES AND PAIN | GRUENENTHAL GMBH (DE) | 2009-08-05 | — | — | EP | disclosed |
| EP-1341786-B1 | SUBSTITUTED DERIVATIVES OF AMINOFURAN-2-YL-ACETIC ACID AND AMINOTHIEN-2-YL-ACETIC ACID AND THE USE THEREOF FOR TREATING MIGRAINES AND PAIN | GRUENENTHAL GMBH (DE) | 2008-12-24 | — | — | EP | disclosed |
| US-6797712-B2 | Substituted amino-furan-2-yl-acetic acid and amino-thien-2-yl-acetic acid derivatives and their use in the treatment of migraine and pain | GRUENENTHAL GMBH (DE) | 2004-09-28 | — | — | US | disclosed |
| US-20040030156-A1 | Substituted amino-furan-2-yl-acetic acid and amino-thien-2-yl-acetic acid derivatives and their use in the treatment of migraine and pain | GRUENENTHAL GMBH (DE) | 2004-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040030156-A1 | Substituted amino-furan-2-yl-acetic acid and amino-thien-2-yl-acetic acid derivatives and their use in the treatment of migraine and pain | AADAT, TRPA1, CACNA1I | CA1 570/4885CA14 2568/4885EGFR 4339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.