Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | RARG | P13631 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.48 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15902594 | 1.00 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1MAPK1SLC15A1CYP1A2 | |
| SCHEMBL18510019 | 0.91 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1MAPK1SLC15A1CYP1A2 | |
| SCHEMBL21878225 | 0.88 | ALDH1A1 (0.45) | ALDH1A1L3MBTL1MAPK1KMT2AMAPT | |
| SCHEMBL21878224 | 0.88 | ALDH1A1 (0.45) | ALDH1A1L3MBTL1MAPK1KMT2AMAPT | |
| SCHEMBL10832272 | 0.87 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1MAPK1SLC15A1CYP1A2 | |
| SCHEMBL6902109 | 0.87 | L3MBTL1 (0.49) | ALDH1A1L3MBTL1MAPK1SLC15A1CYP1A2 | |
| SCHEMBL20833056 | 0.87 | TSHR (0.50) | ALDH1A1L3MBTL1MAPK1SLC15A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL10832268 | 0.86 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1MAPK1SLC15A1CYP1A2 | |
| SCHEMBL2816306 | 0.86 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1MAPK1SLC15A1CYP1A2 | |
| SCHEMBL21878155 | 0.85 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1MAPK1SLC15A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220402926-A1 | NOVEL MACROCYCLIC SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS | ENANTA PHARMACEUTICALS, INC. | 2022-12-22 | — | — | US | disclosed |
| US-11084794-B2 | Controlled cyclization of peptoids to form chiral diketopiperazines | TRIAD NATIONAL SECURITY, LLC (US) | 2021-08-10 | — | — | US | disclosed |
| US-20210115013-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2021-04-22 | — | — | US | disclosed |
| US-20200131140-A1 | CONTROLLED CYCLIZATION OF PEPTOIDS TO FORM CHIRAL DIKETOPIPERAZINES | TRIAD NATIONAL SECURITY, LLC (US) | 2020-04-30 | — | — | US | disclosed |
| US-20190330183-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-10-31 | — | — | US | disclosed |
| EP-3019172-B1 | PRO-DRUG FORMING COMPOUNDS | EVESTRA INC (US) | 2019-09-25 | — | — | EP | disclosed |
| US-10273263-B2 | Pro-drug forming compounds | EVESTRA, INC. (US) | 2019-04-30 | — | — | US | disclosed |
| US-20170349624-A1 | PRO-DRUG FORMING COMPOUNDS | EVESTRA, INC. | 2017-12-07 | — | — | US | disclosed |
| US-9745338-B2 | Pro-drug forming compounds | EVESTRA, INC. (US) | 2017-08-29 | — | — | US | disclosed |
| EP-3019172-A1 | PRO-DRUG FORMING COMPOUNDS | Evestra, Inc. (US) | 2016-05-18 | — | — | EP | disclosed |
| WO-2015006691-A1 | PRO-DRUG FORMING COMPOUNDS | EVESTRA, INC. (US) | 2015-01-15 | — | — | WO | disclosed |
| EP-2086938-B1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2012-01-25 | — | — | EP | disclosed |
| US-8058272-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-11-15 | — | — | US | disclosed |
| US-7888351-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-02-15 | — | — | US | disclosed |
| US-20110034462-A1 | ORGANIC COMPOUNDS | BAESCHLIN DANIEL KASPAR | 2011-02-10 | — | — | US | disclosed |
| US-20100048571-A1 | Organic Compounds | NOVARTIS AG | 2010-02-25 | — | — | US | disclosed |
| US-20090281069-A1 | ORGANIC COMPOUNDS | BAESCHLIN DANIEL KASPAR | 2009-11-12 | — | — | US | disclosed |
| EP-2086938-A1 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008073306-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2008-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190330183-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | TLR7, TLR8, TLR9 | ALDH1A1 2648/4885L3MBTL1 2469/4885MAPK1 549/4885 |
| US-20220402926-A1 | NOVEL MACROCYCLIC SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS | ACE, ACE2, PKD1 | ALDH1A1 922/4885L3MBTL1 4797/4885MAPK1 723/4885 |
| US-11084794-B2 | Controlled cyclization of peptoids to form chiral diketopiperazines | NPPA, NPEPPS, RRP15 | ALDH1A1 4849/4885L3MBTL1 4335/4885MAPK1 4602/4885 |
| US-20200131140-A1 | CONTROLLED CYCLIZATION OF PEPTOIDS TO FORM CHIRAL DIKETOPIPERAZINES | NPPA, NPEPPS, RRP15 | ALDH1A1 4849/4885L3MBTL1 4335/4885MAPK1 4602/4885 |
| US-20210115013-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | TLR7, TLR8, TLR9 | ALDH1A1 2896/4885L3MBTL1 2745/4885MAPK1 961/4885 |
| US-20170349624-A1 | PRO-DRUG FORMING COMPOUNDS | SUCNR1, FURIN, PROKR2 | ALDH1A1 785/4885L3MBTL1 4782/4885MAPK1 2454/4885 |
| US-20090281069-A1 | ORGANIC COMPOUNDS | OTC, OAT, SLCO2B1 | ALDH1A1 72/4885L3MBTL1 3329/4885MAPK1 4494/4885 |
| US-10273263-B2 | Pro-drug forming compounds | SUCNR1, FURIN, OGFR | ALDH1A1 797/4885L3MBTL1 4738/4885MAPK1 2371/4885 |
| US-20110034462-A1 | ORGANIC COMPOUNDS | OTC, OAT, SLCO2B1 | ALDH1A1 72/4885L3MBTL1 3329/4885MAPK1 4494/4885 |
| US-20100048571-A1 | Organic Compounds | XIAP, BAX, MCL1 | ALDH1A1 2759/4885L3MBTL1 581/4885MAPK1 2144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.