SCHEMBL381291

SCHEMBL381291

O=C(O)CCC(c1ccc(N2C(=O)C=CC2=O)cc1)N1C(=O)CCC1=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.46
ATM Q13315 2/20 0.46
MGLL Q99685 13/20 0.42
DDAH1 O94760 1/20 0.42
FAAH O00519 5/20 0.40
HSP90AA1 P07900 5/20 0.38
TDP1 Q9NUW8 3/20 0.38
PKM P14618 2/20 0.38
NPSR1 Q6W5P4 2/20 0.38
MAPK1 P28482 1/20 0.38
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA9 Q16790 1/20 0.38
ALDH1A1 P00352 3/20 0.36
HPGD P15428 2/20 0.36
HTT P42858 2/20 0.36
LMNA P02545 2/20 0.36
CCR6 P51684 2/20 0.36
MEN1 O00255 1/20 0.36
CACNA1B Q00975 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20681587 0.83 KMT2A (0.39) KMT2AATMMGLLDDAH1FAAH
SCHEMBL29000169 0.82 KMT2A (0.50) KMT2AATMPKMMAPK1ALDH1A1
SCHEMBL1608836 0.74 ALDH1A1 (0.46) KMT2AMGLLMAPK1ALDH1A1HPGD
SCHEMBL29211477 0.73 KMT2A (0.42) KMT2AATMPKMMAPK1ALDH1A1
SCHEMBL1081993 0.71 PTGS1 (0.38) KMT2AATMTDP1PKMMAPK1
SCHEMBL326688 0.71 PKM (0.49) KMT2AMGLLDDAH1FAAHHSP90AA1
SCHEMBL26623027 0.70 ALDH1A1 (0.67) KMT2AMGLLDDAH1FAAHHSP90AA1
SCHEMBL8510655 0.68 MGLL (0.49) MGLLDDAH1FAAHHSP90AA1TDP1
SCHEMBL28882413 0.68 HSP90AA1 (0.43) KMT2AATMMGLLDDAH1FAAH
SCHEMBL15782481 0.68 MGLL (0.48) KMT2AATMMGLLDDAH1FAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2249873-B1 CONJUGATED MOLECULES COMPRISING A PEPTIDE DERIVED FROM THE CD4 RECEPTOR COUPLED TO A POLYANION FOR THE TREATMENT OF AIDS PASTEUR INSTITUT (FR) 2016-11-16 EP claimed
EP-2284284-B1 Antigen detection kit and method KOREA INST SCI & TECH (KR) 2015-02-25 EP claimed
US-20100261244-A1 METHOD FOR IMMOBILIZING BIO-MATERIAL ON TITANIUM DIOXIDE NANOPARTICLES AND TITANIUM DIOXIDE NANOPARTICLES IMMOBILIZED BY BIO-MATERIAL ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE (KR) 2010-10-14 US claimed
WO-2009078513-A1 METHOD FOR IMMOBILIZING BIO-MATERIAL ON TITANIUM DIOXIDE NANOPARTICLES AND TITANIUM DIOXIDE NANOPARTICLES IMMOBILIZED BY BIO-MATERIAL ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE (KR) 2009-06-25 WO claimed
EP-0649857-B1 Peptide having inflammation affinity and radioactive diagnostic containing the same NIHON MEDIPHYSICS CO LTD (JP) 1999-01-20 EP claimed
US-9297800-B2 Biomaterial construct, its producing method, biomaterial support, target material purifying method, affinity chromatography container, separation chip, analyzing method and analyzing separator for target material, biomaterial complex, and its support, sensor chip, solid support with biomaterial fixed thereon MITSUBISHI CHEMICAL CORPORATION (JP) 2016-03-29 US disclosed
US-9273140-B2 Antibody for detecting DNA damage in cells utilizing cell membrane surface antigen Ly6D FUJITA HEALTH UNIVERSITY (JP) 2016-03-01 US disclosed
EP-2515112-B1 Method for electrochemically detecting analyte SYSMEX CORP (JP) 2015-08-12 EP disclosed
EP-2339342-B1 Biomaterial structure, method of producing the same and uses thereof LSI MEDIENCE CORP (JP) 2014-11-12 EP disclosed
CN-102471371-B Homing peptides for tumor vasculature UNIV HONG KONG CHINESE 2014-04-23 CN disclosed
US-20140004536-A1 METHOD FOR DETECTING CELLULAR DNA DAMAGE AND ANTIBODY AGAINST CELL SURFACE ANTIGEN RESPONSIVE TO DNA STRAND BREAKS PERSEUS PROTEOMICS INC. (JP) 2014-01-02 US disclosed
US-20120267258-A1 METHOD FOR ELECTROCHEMICALLY DETECTING ANALYTE NARA INSTITUTE OF SCIENCE AND TECHNOLOGY (JP) 2012-10-25 US disclosed
US-20080044925-A1 Biomaterial Construct, Its Producing Method, Biomaterial Support, Target Material Purifying Method, Affinity Chromatography Container, Separation Chip, Analyzing Method and Analyzing Separator for Target Material, Biomaterial Complex, and Its Support, Sensor Chip, Solid Support with Biomaterial Fixed Thereon LSI MEDIENCE CORPORATION (JP) 2008-02-21 US disclosed
US-20080038329-A1 T-CELL ACTIVATING AGENT NOF CORPORATION (JP) 2008-02-14 US disclosed
EP-1813946-A1 BIOMATERIAL CONSTRUCT, ITS PRODUCING METHOD, BIOMATERIAL SUPPORT, TARGET MATERIAL PURIFYING METHOD, AFFINITY CHROMATOGRAPHY CONTAINER, SEPARATION CHIP, ANALYZING METHOD AND ANALYZING SEPARATOR FOR TARGET MATERIAL, BIOMATERIAL COMPLEX, AND ITS SUPPORT, SENSOR CHIP, SOLID SUPPORT WITH BIOMATERIAL FIXE Mitsubishi Chemical Corporation (JP) 2007-08-01 EP disclosed
US-20060071203-A1 Coating composition and optical article TOKUYAMA CORPORATION (JP) 2006-04-06 US disclosed
US-20050266066-A1 Phospholipid membrane preparation NOF CORPORATION (JP) 2005-12-01 US disclosed
EP-1568739-A1 COATING COMPOSITION AND OPTICAL ARTICLE Tokuyama Corporation (JP) 2005-08-31 EP disclosed
US-20050049313-A1 Electron mediator, electron mediator immobilized electrode, and biofuel cell using the electrode DAIICHI PURE CHEMICALS CO., LTD. 2005-03-03 US disclosed
US-5756363-A Liposome reagent for immunoagglutination and immunoanalytical method NISSUI PHARMACEUTICAL CO., LTD. (JP) 1998-05-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050049313-A1 Electron mediator, electron mediator immobilized electrode, and biofuel cell using the electrode SQOR, ME3, VAT1 KMT2A 2726/4885ATM 3851/4885MGLL 2836/4885
US-20140004536-A1 METHOD FOR DETECTING CELLULAR DNA DAMAGE AND ANTIBODY AGAINST CELL SURFACE ANTIGEN RESPONSIVE TO DNA STRAND BREAKS DCLRE1A, DDB1, DNASE1L3 KMT2A 3559/4885ATM 426/4885MGLL 4427/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.