Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Threonine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLUL | P15104 | 1/20 | 0.42 |
| ▸ | GCLC | P48506 | 1/20 | 0.41 |
| ▸ | GRM8 | O00222 | 2/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Threonine SCHEMBL6937624 | 1.00 | GLUL (0.42) | GLULGCLCGRM8GRM4GRM6 | |
| Threonine SCHEMBL6033506 | 0.93 | ALDH1A1 (0.44) | GRM8GRM4GRM6GRM7 | |
| Threonine SCHEMBL6033503 | 0.93 | ALDH1A1 (0.44) | GRM8GRM4GRM6GRM7 | |
| Threonine SCHEMBL12482108 | 0.93 | ALDH1A1 (0.44) | GRM8GRM4GRM6GRM7 | |
| Threonine SCHEMBL27675422 | 0.86 | USP2 (0.41) | GLUL | |
| Homoserine SCHEMBL383537 | 0.85 | GLUL (0.53) | GLULGCLCGRM8GRM4GRM6 | |
| Homoserine SCHEMBL27518745 | 0.85 | GLUL (0.53) | GLULGCLCGRM8GRM4GRM6 | |
| Homoserine SCHEMBL60700 | 0.85 | GLUL (0.53) | GLULGCLCGRM8GRM4GRM6 | |
| Threonine SCHEMBL1193769 | 0.83 | SLC7A5 (0.52) | — | |
| Threonine SCHEMBL8934992 | 0.83 | SLC7A5 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101386-B2 | Escherichia coli strains which over-produce L-threonine and processes for the production of L-threonine by fermentation | ARCHER DANIELS MIDLAND COMPANY (US) | 2012-01-24 | — | — | US | disclosed |
| EP-1322765-B1 | ESCHERICHIA COLI/ STRAINS WHICH OVER-PRODUCE L-THREONINE AND PROCESSES FOR THE PRODUCTION OF L-THREONINE BY FERMENTATION | ARCHER DANIELS MIDLAND CO (US) | 2011-06-15 | — | — | EP | disclosed |
| US-20100267095-A1 | ESCHERICHIA COLI STRAINS WHICH OVER-PRODUCE L-THREONINE AND PROCESSES FOR THE PRODUCTION OF L-THREONINE BY FERMENTATION | LIAW HUNGMING J | 2010-10-21 | — | — | US | disclosed |
| US-7767431-B2 | Escherichia coli strains which over-produce L-threonine and processes for the production of L-threonine by fermentation | ARCHER-DANIELS-MIDLAND COMPANY (US) | 2010-08-03 | — | — | US | disclosed |
| US-20100159537-A1 | ESCHERICHIA COLI STRAINS THAT OVER-PRODUCE L-THREONINE AND PROCESSES FOR THEIR PRODUCTION | D ELIA JOHN N | 2010-06-24 | — | — | US | disclosed |
| US-7723097-B2 | Escherichia coli strains that over-produce L-threonine and processes for their production | ARCHER-DANIELS-MIDLAND COMPANY (US) | 2010-05-25 | — | — | US | disclosed |
| US-7687253-B2 | Escherichia coli strains which over-produce L-threonine and processes for the production of L-threonine by fermentation | ARCHER-DANIELS-MIDLAND COMPANY (US) | 2010-03-30 | — | — | US | disclosed |
| EP-0917578-B1 | NOVEL STRAINS OF ESCHERICHIA COLI, METHODS OF PREPARING THE SAME AND USE THEREOF IN FERMENTATION PROCESSES FOR L-THREONINE PRODUCTION | ARCHER DANIELS MIDLAND CO (US) | 2009-01-21 | — | — | EP | disclosed |
| US-20080166788-A1 | Escherichia Coli Strains which Over-Produce L-Threonine and Processes for the Production of L-Threonine by Fermentation | ARCHER-DANIELS-MIDLAND COMPANY (US) | 2008-07-10 | — | — | US | disclosed |
| US-20070254337-A1 | Escherichia coli strains which over-produce L-threonine and processes for the production of L-threonine by fermentation | ARCHER- DANIELS-MIDLAND COMPANY (US) | 2007-11-01 | — | — | US | disclosed |
| US-7220571-B2 | Escherichia coli strains which over-produce L-threonine and processes for the production of L-threonine by fermentation | ARCHER-DANIELS-MIDLAND COMPANY (US) | 2007-05-22 | — | — | US | disclosed |
| US-20060205044-A1 | Escherichia coli strains that over-produce L-threonine and processes for their production | ARCHER-DANIELS-MIDLAND COMPANY | 2006-09-14 | — | — | US | disclosed |
| US-20020106800-A1 | Escherichia coli strains which over-produce L-thereonine and processes for the production of L-threonine by fermentation | ARCHER-DANIELS-MIDLAND COMPANY | 2002-08-08 | — | — | US | disclosed |
| US-5939307-A | GENETIC ENGINEERING | THE ARCHER-DANIELS-MIDLAND COMPANY (US) | 1999-08-17 | — | — | US | disclosed |
| EP-0917578-A1 | NOVEL STRAINS OF $i(ESCHERICHIA COLI), METHODS OF PREPARING THE SAME AND USE THEREOF IN FERMENTATION PROCESSES FOR L-THREONINE PRODUCTION | ARCHER-DANIELS-MIDLAND COMPANY (US) | 1999-05-26 | — | — | EP | disclosed |
| WO-1998004715-A9 | NOVEL STRAINS OF ESCHERICHIA COLI, METHODS OF PREPARING THE SAME AND USE THEREOF IN FERMENTATION PROCESSES FOR L-THREONINE PRODUCTION | — | 1998-05-22 | — | — | WO | disclosed |
| WO-1998004715-A1 | NOVEL STRAINS OF ESCHERICHIA COLI, METHODS OF PREPARING THE SAME AND USE THEREOF IN FERMENTATION PROCESSES FOR L-THREONINE PRODUCTION | ARCHER-DANIELS-MIDLAND COMPANY (US) | 1998-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100159537-A1 | ESCHERICHIA COLI STRAINS THAT OVER-PRODUCE L-THREONINE AND PROCESSES FOR THEIR PRODUCTION | TKT, MRPL21, ALDH7A1 | GLUL 38/4885GCLC 751/4885GRM8 1956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.