Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Threonine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLUL | P15104 | 1/20 | 0.42 |
| ▸ | GCLC | P48506 | 1/20 | 0.41 |
| ▸ | GRM8 | O00222 | 2/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Threonine SCHEMBL382179 | 1.00 | GLUL (0.42) | GLULGCLCGRM8GRM4GRM6 | |
| Threonine SCHEMBL6033506 | 0.93 | ALDH1A1 (0.44) | GRM8GRM4GRM6GRM7 | |
| Threonine SCHEMBL6033503 | 0.93 | ALDH1A1 (0.44) | GRM8GRM4GRM6GRM7 | |
| Threonine SCHEMBL12482108 | 0.93 | ALDH1A1 (0.44) | GRM8GRM4GRM6GRM7 | |
| Threonine SCHEMBL27675422 | 0.86 | USP2 (0.41) | GLUL | |
| Homoserine SCHEMBL383537 | 0.85 | GLUL (0.53) | GLULGCLCGRM8GRM4GRM6 | |
| Homoserine SCHEMBL27518745 | 0.85 | GLUL (0.53) | GLULGCLCGRM8GRM4GRM6 | |
| Homoserine SCHEMBL60700 | 0.85 | GLUL (0.53) | GLULGCLCGRM8GRM4GRM6 | |
| Threonine SCHEMBL1193769 | 0.83 | SLC7A5 (0.52) | — | |
| Threonine SCHEMBL8934992 | 0.83 | SLC7A5 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322765-A1 | ESCHERICHIA COLI/ STRAINS WHICH OVER-PRODUCE L-THREONINE AND PROCESSES FOR THE PRODUCTION OF L-THREONINE BY FERMENTATION | Archer-Daniels-Midland Company (US) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002026993-A1 | ESCHERICHIA COLI STRAINS WHICH OVER-PRODUCE L-THREONINE AND PROCESSES FOR THE PRODUCTION OF L-THREONINE BY FERMENTATION | ARCHER-DANIELS-MIDLAND COMPANY (US) | 2002-04-04 | — | — | WO | disclosed |