Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ME2 | P23368 | 2/20 | 0.49 |
| ▸ | ME1 | P48163 | 2/20 | 0.49 |
| ▸ | ME3 | Q16798 | 2/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | EP300 | Q09472 | 1/20 | 0.46 |
| ▸ | MLYCD | O95822 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3830332 | 0.86 | MEN1 (0.45) | ALDH1A1TSHRKDM4EME2ME1 | |
| SCHEMBL3828535 | 0.85 | ALDH1A1 (0.45) | ALDH1A1TSHRKDM4EME2ME1 | |
| SCHEMBL8184147 | 0.83 | L3MBTL1 (0.47) | ALDH1A1TSHRKDM4EME2ME1 | |
| SCHEMBL3826601 | 0.83 | RAB9A (0.48) | ALDH1A1TSHRKDM4EME2ME1 | |
| SCHEMBL3823632 | 0.83 | L3MBTL1 (0.45) | ALDH1A1TSHRKDM4EME2ME1 | |
| SCHEMBL3053852 | 0.82 | ME2 (0.43) | ALDH1A1TSHRKDM4EME2ME1 | |
| SCHEMBL8177578 | 0.82 | OPRM1 (0.45) | ALDH1A1TSHRKDM4EME2ME1 | |
| SCHEMBL4737954 | 0.82 | KDM4E (0.45) | ALDH1A1TSHRKDM4EME2ME1 | |
| SCHEMBL3827091 | 0.82 | L3MBTL1 (0.44) | ALDH1A1TSHRKDM4EME2ME1 | |
| SCHEMBL3860025 | 0.82 | L3MBTL1 (0.53) | ALDH1A1TSHRKDM4EME2ME1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097379-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-09-09 | — | — | EP | claimed |
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |