Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | OAT | P04181 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4522597 | 0.84 | LMNA (0.38) | ALDH1A1CRHBPCRHR2HIF1AKDM4E | |
| SCHEMBL3840279 | 0.80 | OAT (0.37) | ALDH1A1OAT | |
| SCHEMBL3838127 | 0.72 | OAT (0.37) | ALDH1A1CYP1A2POLBKDM4EMAPT | |
| SCHEMBL3842597 | 0.71 | DUT (0.34) | — | |
| SCHEMBL9432586 | 0.69 | ALDH1A1 (0.33) | ALDH1A1KDM4ELMNAMAPTTP53 | |
| SCHEMBL9432543 | 0.67 | ALDH1A1 (0.35) | ALDH1A1CYP1A2KDM4ELMNAMAPT | |
| SCHEMBL3838170 | 0.67 | OAT (0.31) | OAT | |
| SCHEMBL9432630 | 0.66 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPTTP53 | |
| SCHEMBL9432597 | 0.66 | SLC6A3 (0.42) | ALDH1A1POLBKDM4E | |
| SCHEMBL3840294 | 0.66 | SLC6A1 (0.52) | ALDH1A1CYP1A2KDM4ELMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931341-B1 | 1H-INDOLE-PYRIDINECARBOXAMIDE AND 1H-INDOLE-PIPERIDINECARBOXAMIDE DERIVATIVES AND THEIR USE AS TYROSINE HYDROXYLASE INDUCERS | SERVIER LAB (FR) | 2009-11-04 | — | — | EP | disclosed |