Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.67 |
| ▸ | MAOB | P27338 | 1/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NT5E | P21589 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 4/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4163817 | 0.89 | MAOA (0.67) | MAOAMAOBRXFP1CYP1A2CYP2D6 | |
| SCHEMBL11780381 | 0.82 | MAOA (0.75) | MAOAMAOBCYP1A2CYP2D6HTT | |
| SCHEMBL15124839 | 0.82 | MAOA (0.82) | MAOAMAOBCYP1A2HTTACHE | |
| SCHEMBL455949 | 0.82 | MAOA (1.00) | MAOAMAOBHTTACHEKMT2A | |
| SCHEMBL27889436 | 0.82 | MAOA (1.00) | MAOAMAOBHTTACHEKMT2A | |
| Hydrochloric Acid SCHEMBL28400797 | 0.80 | MAOA (0.95) | MAOAMAOBHTTACHEKMT2A | |
| SCHEMBL6527287 | 0.78 | DHODH (0.44) | MAOAMAOBRXFP1CYP1A2CYP2D6 | |
| SCHEMBL515743 | 0.78 | HTT (0.50) | MAOAMAOBRXFP1CYP1A2CYP2D6 | |
| SCHEMBL30981743 | 0.78 | PRNP (0.47) | MAOARXFP1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL13696895 | 0.78 | ACHE (0.67) | MAOACYP1A2HTTACHEHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9127164-B2 | Fluorescent dyes and uses thereof | ALMAC SCIENCES (SCOTLAND) LIMITED (GB) | 2015-09-08 | — | — | US | disclosed |
| US-9127164-B2 | Fluorescent dyes and uses thereof | ALMAC SCIENCES (SCOTLAND) LIMITED (GB) | 2015-09-08 | — | — | US | disclosed |
| EP-1940965-B1 | NOVEL FLUORESCENT DYES AND USES THEREOF | ALMAC SCIENCES SCOTLAND LTD (GB) | 2014-03-26 | — | — | EP | disclosed |
| US-20090226940-A1 | NOVEL FLUORESCENT DYES AND USES THEREOF | ITI SCOTLAND LIMITED (GB) | 2009-09-10 | — | — | US | disclosed |
| US-20090226940-A1 | NOVEL FLUORESCENT DYES AND USES THEREOF | ITI SCOTLAND LIMITED (GB) | 2009-09-10 | — | — | US | disclosed |
| EP-1687275-A4 | PYRIDIN-4-YLAMINE COMPOUNDS USEFUL IN THE TREATMENT OF NEUROPATHIC PAIN | MERCK & CO INC (US) | 2009-01-14 | — | — | EP | disclosed |
| US-20070099950-A1 | Pyridin-4-ylamine compounds useful in the treatment of neuropathic pain | AGT SCIENCE LIMITED (GB) | 2007-05-03 | — | — | US | disclosed |
| WO-2007049057-A2 | NOVEL FLUORESCENT DYES AND USES THEREOF | ITI SCOTLAND LIMITED (GB) | 2007-05-03 | — | — | WO | disclosed |
| CN-1882546-A | Pyridin-4-ylamine compounds useful in the treatment of neuropathic pain | MERCK & CO INC (US) | 2006-12-20 | — | — | CN | disclosed |
| EP-1687275-A1 | PYRIDIN-4-YLAMINE COMPOUNDS USEFUL IN THE TREATMENT OF NEUROPATHIC PAIN | Merck & Co., Inc. (US) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005051915-A1 | PYRIDIN-4-YLAMINE COMPOUNDS USEFUL IN THE TREATMENT OF NEUROPATHIC PAIN | MERCK & CO., INC. (US) | 2005-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090226940-A1 | NOVEL FLUORESCENT DYES AND USES THEREOF | ACR, ANXA5, GLB1 | MAOA 1446/4885MAOB 1128/4885RXFP1 4783/4885 |
| US-20070099950-A1 | Pyridin-4-ylamine compounds useful in the treatment of neuropathic pain | PER2, CNR2, OPRD1 | MAOA 2116/4885MAOB 1852/4885RXFP1 2132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.