Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | BCL2 | P10415 | 1/20 | 0.50 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.48 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3892580 | 0.85 | KAT6A (0.50) | CNR2KAT6ALOXL2CYP4F2CYP4A11 | |
| SCHEMBL4950108 | 0.83 | ALDH1A1 (0.48) | LOXL2CYP4F2CYP4A11ALDH1A1TSHR | |
| SCHEMBL11611076 | 0.83 | CNR2 (0.62) | CNR2BCL2KAT6ASMYD3LOXL2 | |
| SCHEMBL8087128 | 0.82 | CYP4F2 (0.51) | CYP4F2CYP4A11SMN1; SMN2 | |
| SCHEMBL30394310 | 0.82 | BCL2 (0.66) | BCL2ALDH1A1FOLH1TP53PKM | |
| SCHEMBL29472003 | 0.82 | TSHR (0.47) | LOXL2CYP4F2CYP4A11ALDH1A1TSHR | |
| SCHEMBL16240333 | 0.82 | PRSS1 (0.55) | CNR2SMYD3LOXL2CYP4F2CYP4A11 | |
| SCHEMBL39676 | 0.82 | TSHR (0.47) | LOXL2CYP4F2CYP4A11ALDH1A1TSHR | |
| SCHEMBL46935 | 0.82 | BCL2 (0.66) | BCL2ALDH1A1FOLH1TP53PKM | |
| SCHEMBL8099947 | 0.82 | BCL2 (0.51) | CNR2BCL2KAT6ASMYD3LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115626894-B | Lappaconitine derivative with analgesic activity, and preparation method and application thereof | 西南交通大学 | 2025-04-18 | — | — | CN | disclosed |
| US-11840517-B2 | Lappaconitine derivative with analgesic activity, and preparation and application thereof | SOUTHWEST JIAOTONG UNIVERSITY (CN) | 2023-12-12 | — | — | US | disclosed |
| CN-115626894-A | Lappaconitine derivative with analgesic activity and preparation method and application thereof | 西南交通大学 | 2023-01-20 | — | — | CN | disclosed |
| CN-113105391-B | Lappaconitine derivative with analgesic activity and preparation method and application thereof | 西南交通大学 | 2022-12-16 | — | — | CN | disclosed |
| CN-110372571-B | 2- (2, 2-diarylethyl) -cyclic amine derivative or salt, synthesis and application thereof, and composition | 中国科学院大连化学物理研究所 | 2022-11-15 | — | — | CN | disclosed |
| WO-2022129047-A2 | NOVEL MODULATORS OF THE NMDA RECEPTOR | H. LUNDBECK A/S (DK) | 2022-06-23 | — | — | WO | disclosed |
| US-20220144779-A1 | LAPPACONITINE DERIVATIVE WITH ANALGESIC ACTIVITY, AND PREPARATION AND APPLICATION THEREOF | SOUTHWEST JIAOTONG UNIVERSITY (CN) | 2022-05-12 | — | — | US | disclosed |
| CN-113105391-A | Lappaconitine derivative with analgesic activity and preparation method and application thereof | 西南交通大学 | 2021-07-13 | — | — | CN | disclosed |
| US-20210155591-A1 | 2-(2,2-DIARYLETHYL)-CYCLIC AMINE DERIVATIVE OR SALT, SYNTHESIS THEREOF, AND APPLICATION AND COMPOSITION THEREOF | DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES (CN) | 2021-05-27 | — | — | US | disclosed |
| US-20210155591-A1 | 2-(2,2-DIARYLETHYL)-CYCLIC AMINE DERIVATIVE OR SALT, SYNTHESIS THEREOF, AND APPLICATION AND COMPOSITION THEREOF | DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES (CN) | 2021-05-27 | — | — | US | disclosed |
| EP-1205478-A1 | p38MAP KINASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001074811-A2 | SUBSTITUTED 1,3-THIAZOLE COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-10-11 | — | — | WO | disclosed |
| EP-0708077-B1 | Diamino compounds and methods for preparing them | CHISSO CORP (JP) | 2000-12-27 | — | — | EP | disclosed |
| WO-1998005961-A1 | COMPOUNDS HAVING A PLURALITY OF NITROGENOUS SUBSTITUENTS | ISIS PHARMACEUTICALS, INC. (US) | 1998-02-12 | — | — | WO | disclosed |
| US-5663440-A | Diamino compounds and methods for preparing them | CHISSO CORPORATION (JP) | 1997-09-02 | — | — | US | disclosed |
| EP-0708077-A1 | Diamino compounds and methods for preparing them | CHISSO CORPORATION (JP) | 1996-04-24 | — | — | EP | disclosed |
| EP-0461809-B1 | Dibenzoylalkylcyanohydrazines | ROHM & HAAS (US) | 1994-12-07 | — | — | EP | disclosed |
| EP-0461809-A1 | Dibenzoylalkylcyanohydrazines | ROHM AND HAAS COMPANY (US) | 1991-12-18 | — | — | EP | disclosed |
| US-4003909-A | [(1,2,4-Oxadiazol-3-yl)phenyl]carbamic or thiocarbamic acid esters | E. R. SQUIBB & SONS, INC. (US) | 1977-01-18 | — | — | US | disclosed |
| US-3939162-A | Anthrapyrimidine dyes | BASF AKTIENGESELLSCHAFT (DT) | 1976-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210155591-A1 | 2-(2,2-DIARYLETHYL)-CYCLIC AMINE DERIVATIVE OR SALT, SYNTHESIS THEREOF, AND APPLICATION AND COMPOSITION THEREOF | CHRNB2, ADRB2, CHRNB1 | CNR2 69/4885BCL2 2607/4885KAT6A 3993/4885 |
| US-11840517-B2 | Lappaconitine derivative with analgesic activity, and preparation and application thereof | LPXN, ACHE, OPRL1 | CNR2 811/4885BCL2 4307/4885KAT6A 2339/4885 |
| US-20220144779-A1 | LAPPACONITINE DERIVATIVE WITH ANALGESIC ACTIVITY, AND PREPARATION AND APPLICATION THEREOF | LPXN, ACHE, OPRL1 | CNR2 811/4885BCL2 4307/4885KAT6A 2339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.