Sugi Predict

Sugi Predict / Compounds / SCHEMBL3918890

SCHEMBL3918890

SCHEMBL3918890

O=C1CCN(S(=O)(=O)c2ccccc2)CC1

nearest known ligand 0.68

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.68
▸ GAA P10253 2/20 0.64
▸ POLB P06746 2/20 0.61
▸ MEN1 O00255 2/20 0.61
▸ PKM P14618 3/20 0.59
▸ ALDH1A1 P00352 4/20 0.58
▸ LMNA P02545 1/20 0.58
▸ CYP2C9 P11712 1/20 0.55
▸ PARL Q9H300 1/20 0.55
▸ CYP2D6 P10635 1/20 0.54
▸ MAPK1 P28482 1/20 0.54
▸ L3MBTL1 Q9Y468 1/20 0.54
▸ APOBEC3A P31941 1/20 0.53
▸ APOBEC3G Q9HC16 1/20 0.53
▸ TSHR P16473 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12626008 0.89 GAA (0.72) KMT2AGAAPOLBMEN1PKM
SCHEMBL3830424 0.85 POLB (0.80) GAAPOLBPKMALDH1A1LMNA
SCHEMBL735657 0.85 POLB (0.80) GAAPOLBPKMALDH1A1LMNA
SCHEMBL7122592 0.85 POLB (0.80) GAAPOLBPKMALDH1A1LMNA
SCHEMBL12939706 0.84 ALDH1A1 (0.73) KMT2AGAAPOLBMEN1PKM
SCHEMBL8220170 0.82 GAA (0.62) KMT2AGAAPOLBMEN1PKM
SCHEMBL6805741 0.81 ALDH1A1 (0.81) GAAPOLBPKMALDH1A1LMNA
SCHEMBL1988224 0.81 ALDH1A1 (0.81) GAAPOLBPKMALDH1A1LMNA
SCHEMBL14470279 0.81 ALDH1A1 (0.75) KMT2AGAAPOLBMEN1PKM
SCHEMBL505093 0.81 KMT2A (0.69) KMT2AGAAPOLBMEN1PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109053564-A The asymmetric piperidines ketone compound and preparation method thereof that N- benzenesulfonyl replaces 滨州医学院 2018-12-21 — — CN claimed
CN-109053565-A Asymmetric pyridine-piperidines ketone compound and preparation method thereof that N- benzenesulfonyl replaces 滨州医学院 2018-12-21 — — CN claimed
US-20260034125-A1 N-PHENYL-1-(PHENYLSULFONYL)PIPERIDIN-4-AMINE DERIVATIVES AS CCR6 INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2026-02-05 — — US disclosed
EP-4661964-A1 COMPOUNDS AS CCR6 INHIBITORS F. Hoffmann-La Roche AG (CH) 2025-12-17 — — EP disclosed
US-20250353859-A1 COMPOUNDS AS CCR6 INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2025-11-20 — — US disclosed
WO-2024165453-A1 COMPOUNDS AS CCR6 INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2024-08-15 — — WO disclosed
US-11661580-B2 Method of inhibiting tau phosphorylation CASSAVA SCIENCES, INC. (US) 2023-05-30 — — US disclosed
US-11661580-B2 Method of inhibiting tau phosphorylation CASSAVA SCIENCES, INC. (US) 2023-05-30 — — US disclosed
US-11385221-B2 Alzheimer's disease assay in a living patient PAIN THERAPEUTICS, INC. (US) 2022-07-12 — — US disclosed
US-20210389298-A1 Alzheimer's Disease Assay in a Living Patient PAIN THERAPEUTICS, INC. (US) 2021-12-16 — — US disclosed
EP-3890715-A1 THERAPEUTICS TARGETING MUTANT ADENOMATOUS POLYPOSIS COLI (APC) FOR THE TREATMENT OF CANCER The Board Of Regents Of The University Of Texas System (US) 2021-10-13 — — EP disclosed
WO-2005081954-A2 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B WYETH (US) 2005-09-09 — — WO disclosed
US-20050182040-A1 Benzamide derivatives DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2005-08-18 — — US disclosed
US-6906205-B2 Spiro and dispiro 1,2,4-trioxolane antimalarials MEDICINES FOR MALARIA VENTURE MMV (CH) 2005-06-14 — — US disclosed
EP-1500643-A1 BENZAMIDE DERIVATIVES SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2005-01-26 — — EP disclosed
CN-1545508-A 1,2,4-trioxolane antimalarials ű��ҩ�﹫˾ 2004-11-10 — — CN disclosed
US-20040186168-A1 Such as spiroadamantane on one side and 4-substituted spiro-cyclohexyl on other side; structurally simple, nontoxic, easy synthesis, potent parasiticides MEDICINES FOR MALARIA VENTURE MMV (CH) 2004-09-23 — — US disclosed
EP-1414813-A1 1,2,4-TRIOXOLANE ANTIMALARIALS Medicines for Malaria Venture (CH) 2004-05-06 — — EP disclosed
WO-2003000676-A1 1,2,4-TRIOXOLANE ANTIMALARIALS MEDICINES FOR MALARIA VENTURE (CH) 2003-01-03 — — WO disclosed
US-6486199-B1 Spiro and dispiro 1,2,4-trioxolane antimalarials MEDICINES FOR MALARIA VENTURE MMV INTERNATIONAL CENTRE COINTRIN (CH) 2002-11-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11661580-B2 Method of inhibiting tau phosphorylation FLNA, FLNB, MAPT KMT2A 1560/4885GAA 4737/4885POLB 2356/4885
US-20040186168-A1 Such as spiroadamantane on one side and 4-substituted spiro-cyclohexyl on other side; structurally simple, nontoxic, easy synthesis, potent parasiticides DHODH, SQLE, SULT1E1 KMT2A 3756/4885GAA 4404/4885POLB 4326/4885
US-20260034125-A1 N-PHENYL-1-(PHENYLSULFONYL)PIPERIDIN-4-AMINE DERIVATIVES AS CCR6 INHIBITORS CCR6, CCR1, CCR4 KMT2A 3982/4885GAA 3641/4885POLB 3219/4885
US-20250353859-A1 COMPOUNDS AS CCR6 INHIBITORS CCR6, CCR4, CCR1 KMT2A 3801/4885GAA 3474/4885POLB 3025/4885
US-20050182040-A1 Benzamide derivatives ROCK1, ROCK2, NHERF1 KMT2A 1307/4885GAA 2875/4885POLB 4155/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.