Diphenylmethane

Diphenylmethane

SCHEMBL3943306

CNC.c1ccc(Cc2ccccc2)cc1

nearest known ligand 0.80

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CALM1 P0DP23 1/20 0.80
KDM4E B2RXH2 1/20 0.57
CYP3A4 P08684 1/20 0.57
MAPT P10636 1/20 0.57
LTA4H P09960 1/20 0.56
TAAR1 Q96RJ0 3/20 0.55
ATM Q13315 1/20 0.55
TP53 P04637 1/20 0.53
LMNA P02545 2/20 0.52
SIGMAR1 Q99720 2/20 0.50
SLC18A2 Q05940 1/20 0.50
CYP2D6 P10635 1/20 0.50
L3MBTL1 Q9Y468 2/20 0.48
IDH1 O75874 1/20 0.48
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
PLA2G10 O15496 1/20 0.46
PLA2G2A P14555 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Diphenylmethane SCHEMBL27450549 0.90 CALM1 (0.86) CALM1KDM4ECYP3A4MAPTLTA4H
Diphenylmethane SCHEMBL1303 0.89 CALM1 (1.00) CALM1KDM4ECYP3A4MAPTLTA4H
Diphenylmethane SCHEMBL28172316 0.89 CALM1 (1.00) CALM1KDM4ECYP3A4MAPTLTA4H
Diphenylmethane SCHEMBL3792579 0.89 CALM1 (1.00) CALM1KDM4ECYP3A4MAPTLTA4H
Diphenylmethane SCHEMBL4361124 0.89 CALM1 (1.00) CALM1KDM4ECYP3A4MAPTLTA4H
Diphenylmethane SCHEMBL14763944 0.89 CALM1 (1.00) CALM1KDM4ECYP3A4MAPTLTA4H
Diphenylmethane SCHEMBL27576617 0.87 CALM1 (0.80) CALM1KDM4ECYP3A4MAPTLTA4H
Diphenylmethane SCHEMBL25402252 0.86 CALM1 (0.92) CALM1KDM4ECYP3A4MAPTLTA4H
Diphenylmethane SCHEMBL9958926 0.86 CALM1 (0.92) CALM1KDM4ECYP3A4MAPTLTA4H
Diphenylmethane SCHEMBL22462139 0.86 CALM1 (0.92) CALM1KDM4ECYP3A4MAPTLTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10973740-B2 Powder-liquid type denture base lining material TOKUYAMA DENTAL CORPORATION (JP) 2021-04-13 US disclosed
EP-3488842-B1 POWDER-LIQUID TYPE DENTAL PLATE LINER TOKUYAMA DENTAL CORP (JP) 2021-03-24 EP disclosed
EP-3342370-B1 REFERENCE DENTAL PLATE, REFERENCE DENTURE, DENTURE FABRICATION KIT AND DENTURE FABRICATION METHOD TOKUYAMA DENTAL CORP (JP) 2020-10-14 EP disclosed
US-20190216689-A1 POWDER-LIQUID TYPE DENTURE BASE LINING MATERIAL TOKUYAMA DENTAL CORPORATION (JP) 2019-07-18 US disclosed
EP-3488842-A1 POWDER-LIQUID TYPE DENTAL PLATE LINER Tokuyama Dental Corporation (JP) 2019-05-29 EP disclosed
US-10299897-B2 Dental plate liner TOKUYAMA DENTAL CORPORATION (JP) 2019-05-28 US disclosed
US-20190083210-A1 STANDARD DENTAL PLATE, STANDARD DENTURE, DENTURE FABRICATION KIT AND DENTURE FABRICATION METHOD TOKUYAMA DENTAL CORPORATION (JP) 2019-03-21 US disclosed
EP-3342370-A1 REFERENCE DENTAL PLATE, REFERENCE DENTURE, DENTURE FABRICATION KIT AND DENTURE FABRICATION METHOD Tokuyama Dental Corporation (JP) 2018-07-04 EP disclosed
US-20170007378-A1 DENTAL PLATE LINER TOKUYAMA DENTAL CORPORATION (JP) 2017-01-12 US disclosed
EP-3093000-A1 DENTAL PLATE LINER Tokuyama Dental Corporation (JP) 2016-11-16 EP disclosed
CN-101535411-A Colorant compositions and their use as ph sensitive color indicators MILLIKEN & CO (US) 2009-09-16 CN disclosed
EP-1348416-B1 ADHESIVE COMPOSITIONS FOR BACK-COATING DENTAL PLATE AND HARDENING COMPOSITIONS FOR DENTAL USE TOKUYAMA CORP (JP) 2009-04-22 EP disclosed
US-7056961-B2 Adhesive composition for denture base relining material and dental curable composition TOKUYAMA CORPORATION (JP) 2006-06-06 US disclosed
US-20040048948-A1 Adhesive composition for denture base relining material and dental curable composition TOKUYAMA DENTAL CORPORATION (JP) 2004-03-11 US disclosed
EP-1348416-A1 ADHESIVE COMPOSITIONS FOR BACK-COATING DENTAL PLATE AND HARDENING COMPOSITIONS FOR DENTAL USE TOKUYAMA CORPORATION (JP) 2003-10-01 EP disclosed
EP-0717402-A2 Optical recording elements having recording layers containing cationic azo dyes EASTMAN KODAK COMPANY (US) 1996-06-19 EP disclosed
US-5051504-A Dyes for coloring paper BASF AKTIENGESELLSCHAFT (DE) 1991-09-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10973740-B2 Powder-liquid type denture base lining material TAS2R8, TAS2R1, AOC1 CALM1 2089/4885KDM4E 813/4885CYP3A4 2869/4885
US-20190083210-A1 STANDARD DENTAL PLATE, STANDARD DENTURE, DENTURE FABRICATION KIT AND DENTURE FABRICATION METHOD PARL, PSENEN, KLF5 CALM1 3930/4885KDM4E 486/4885CYP3A4 4253/4885
US-20190216689-A1 POWDER-LIQUID TYPE DENTURE BASE LINING MATERIAL TAS2R8, TAS2R1, AOC1 CALM1 2089/4885KDM4E 813/4885CYP3A4 2869/4885
US-20040048948-A1 Adhesive composition for denture base relining material and dental curable composition TAS2R42, TAF1, CAD CALM1 1503/4885KDM4E 447/4885CYP3A4 3406/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.