SCHEMBL39437

SCHEMBL39437

COC(=O)c1c(O)c2c(Cl)cccc2n(C)c1=O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.48
MEN1 O00255 8/20 0.47
KMT2A Q03164 8/20 0.47
ALDH1A1 P00352 3/20 0.46
KDM4E B2RXH2 1/20 0.46
NPC1 O15118 4/20 0.46
HDAC4 P56524 1/20 0.43
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA7 P43166 1/20 0.42
CA9 Q16790 1/20 0.42
CA14 Q9ULX7 1/20 0.42
HIF1A Q16665 3/20 0.41
POLB P06746 2/20 0.41
RAB9A P51151 2/20 0.41
PABPC1 P11940 1/20 0.41
NR4A2 P43354 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.40
ALOX15 P16050 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30336980 0.87 EGFR (0.41) EGFRMEN1KMT2AALDH1A1KDM4E
SCHEMBL10044900 0.87 CA12 (0.48) EGFRMEN1KMT2AALDH1A1KDM4E
SCHEMBL1685962 0.86 ALDH1A1 (0.65) MEN1KMT2AALDH1A1KDM4ENPC1
SCHEMBL16079758 0.85 ALDH1A1 (0.60) EGFRMEN1KMT2AALDH1A1KDM4E
SCHEMBL889415 0.85 EGFR (0.51) EGFRMEN1KMT2AALDH1A1KDM4E
Laquinimod SCHEMBL4695786 0.84 TP53 (0.44) EGFRMEN1KMT2AALDH1A1KDM4E
SCHEMBL10044898 0.84 HDAC4 (0.58) EGFRMEN1KMT2AALDH1A1KDM4E
SCHEMBL10044899 0.84 ALDH1A1 (0.53) EGFRMEN1KMT2AALDH1A1KDM4E
SCHEMBL2574422 0.83 EGFR (0.47) EGFRMEN1KMT2AALDH1A1KDM4E
SCHEMBL10044897 0.83 KDM4E (0.51) MEN1KMT2AALDH1A1KDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180140592-A1 5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE, SALTS AND USES THEREOF TEVA PHARMACEUTICAL INDUSTRIES, LTD. 2018-05-24 US claimed
US-20170327464-A1 CRYSTALS OF LAQUINIMOD SODIUM AND IMPROVED PROCESS FOR THE MANUFACTURE THEREOF TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) 2017-11-16 US claimed
US-20160279121-A1 5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE, SALTS AND USES THEREOF TEVA PHARMA (IL) 2016-09-29 US claimed
US-20160158216-A1 CRYSTALS OF LAQUINIMOD SODIUM AND IMPROVED PROCESS FOR THE MANUFACTURE THEREOF TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) 2016-06-09 US claimed
US-20160046582-A1 CRYSTALS OF LAQUINIMOD SODIUM AND IMPROVED PROCESS FOR THE MANUFACTURE THEREOF TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2016-02-18 US claimed
EP-2970129-A2 CRYSTALS OF LAQUINIMOD SODIUM AND IMPROVED PROCESS FOR THE MANUFACTURE THEREOF Teva Pharmaceutical Industries Ltd. (IL) 2016-01-20 EP claimed
US-9233927-B2 Crystals of laquinimod sodium and improved process for the manufacture thereof TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) 2016-01-12 US claimed
WO-2014153145-A2 CRYSTALS OF LAQUINIMOD SODIUM AND IMPROVED PROCESS FOR THE MANUFACTURE THEREOF TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2014-09-25 WO claimed
US-20140271878-A1 CRYSTALS OF LAQUINIMOD SODIUM AND IMPROVED PROCESS FOR THE MANUFACTURE THEREOF TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) 2014-09-18 US claimed
EP-2590653-A1 5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE, SALTS AND USES THEREOF Teva Pharmaceutical Industries Ltd. (IL) 2013-05-15 EP claimed
US-20120010239-A1 5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE, SALTS AND USES THEREOF ACTIVE BIOTECH AB (SE) 2012-01-12 US claimed
WO-2012006544-A1 5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE, SALTS AND USES THEREOF TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2012-01-12 WO claimed
US-20120009226-A1 HIGHLY PURE LAQUINIMOD OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF ACTAVIS GROUP PTC EHF (IS) 2012-01-12 US claimed
US-20230202982-A1 5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-QUINOLINE-3-CARBOXAMIDE POTASSIUM SALT FOR TREATING INFLAMMATORY BOWEL DISEASES AQILION AB (SE) 2023-06-29 US disclosed
US-20230167064-A1 TREATMENTS OF INFLAMMATORY BOWEL DISEASE AQILION AB (SE) 2023-06-01 US disclosed
US-20230167064-A1 TREATMENTS OF INFLAMMATORY BOWEL DISEASE AQILION AB (SE) 2023-06-01 US disclosed
EP-1511732-B1 PROCESS FOR THE MANUFACTURE OF QUINOLINE DERIVATIVES ACTIVE BIOTECH AB (SE) 2006-12-20 EP disclosed
US-20050215586-A1 Process for the manufacture of quinoline derivatives ACTIVE BIOTECH AB (SE) 2005-09-29 US disclosed
US-6875869-B2 Process for the manufacture of quinoline derivatives ACTIVE BIOTECH AB (SE) 2005-04-05 US disclosed
US-20040034227-A1 Process for the manufacture of quinoline derivatives ACTIVE BIOTECH AB (SE) 2004-02-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180140592-A1 5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE, SALTS AND USES THEREOF IDH2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HTR2C EGFR 4236/4885MEN1 690/4885KMT2A 83/4885
US-20160046582-A1 CRYSTALS OF LAQUINIMOD SODIUM AND IMPROVED PROCESS FOR THE MANUFACTURE THEREOF HLA-DRB1, HAAO, RECQL EGFR 4590/4885MEN1 3798/4885KMT2A 82/4885
US-20120009226-A1 HIGHLY PURE LAQUINIMOD OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF TLR7, MYD88, PDE7A EGFR 3387/4885MEN1 3210/4885KMT2A 237/4885
US-20170327464-A1 CRYSTALS OF LAQUINIMOD SODIUM AND IMPROVED PROCESS FOR THE MANUFACTURE THEREOF POLQ, MTX1, MTX2 EGFR 4716/4885MEN1 3789/4885KMT2A 15/4885
US-20040034227-A1 Process for the manufacture of quinoline derivatives CYP4F3, HTR3C, CYP3A43 EGFR 2694/4885MEN1 2749/4885KMT2A 2359/4885
US-20050215586-A1 Process for the manufacture of quinoline derivatives ADH5, RPS4Y1, CYP4F3 EGFR 1829/4885MEN1 2560/4885KMT2A 2223/4885
US-20140271878-A1 CRYSTALS OF LAQUINIMOD SODIUM AND IMPROVED PROCESS FOR THE MANUFACTURE THEREOF POLQ, MTX1, TLR7 EGFR 4768/4885MEN1 3589/4885KMT2A 14/4885
US-20160158216-A1 CRYSTALS OF LAQUINIMOD SODIUM AND IMPROVED PROCESS FOR THE MANUFACTURE THEREOF POLQ, MTX1, TLR7 EGFR 4709/4885MEN1 3899/4885KMT2A 15/4885
US-20160279121-A1 5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE, SALTS AND USES THEREOF IDH2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HTR2C EGFR 4236/4885MEN1 690/4885KMT2A 83/4885
US-20230167064-A1 TREATMENTS OF INFLAMMATORY BOWEL DISEASE SLC10A2, SI, ALPI EGFR 3568/4885MEN1 2883/4885KMT2A 3547/4885
US-20120010239-A1 5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE, SALTS AND USES THEREOF IDH2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HTR2C EGFR 4236/4885MEN1 690/4885KMT2A 83/4885
US-20230202982-A1 5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-QUINOLINE-3-CARBOXAMIDE POTASSIUM SALT FOR TREATING INFLAMMATORY BOWEL DISEASES SLC10A2, KCNK5, KCNQ5 EGFR 4451/4885MEN1 2958/4885KMT2A 88/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.