Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | ADK | P55263 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAP2 | P11137 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NGFR | P08138 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | STK17B | O94768 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5187596 | 0.90 | NPC1 (0.41) | ALDH1A1KDM4EGAAMAPTDYRK1A | |
| SCHEMBL3942136 | 0.85 | NPC1 (0.39) | GSK3BADKALDH1A1KDM4EGAA | |
| SCHEMBL3943641 | 0.83 | LHCGR (0.44) | GSK3BADKALDH1A1KDM4EGAA | |
| SCHEMBL3951863 | 0.82 | ALDH1A1 (0.43) | GSK3BADKALDH1A1KDM4EGAA | |
| SCHEMBL3948652 | 0.82 | MAPT (0.60) | GSK3BALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL3951020 | 0.80 | FAAH (0.50) | ALDH1A1 | |
| SCHEMBL3951513 | 0.79 | HTR2C (0.39) | GSK3BADKALDH1A1KDM4EGAA | |
| SCHEMBL4929236 | 0.79 | ALDH1A1 (0.57) | ALDH1A1KDM4EGAAMAPTMAP2 | |
| SCHEMBL3946744 | 0.79 | LIPE (0.41) | GSK3BADKALDH1A1KDM4EGAA | |
| SCHEMBL3942565 | 0.76 | PTGS2 (0.44) | BRD4KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802572-B1 | INDOL DERIVATIVES AS INHIBITORS OF SOLUBLE ADENYLYL CYCLASE | BAYER SCHERING PHARMA AG (DE) | 2009-04-22 | — | — | EP | disclosed |
| EP-1802572-A1 | INDOL DERIVATIVES AS INHIBITORS OF SOLUBLE ADENYLYL CYCLASE | Bayer Schering Pharma Aktiengesellschaft (DE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006032541-A1 | INDOL DERIVATIVES AS INHIBITORS OF SOLUBLE ADENYLYL CYCLASE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2006-03-30 | — | — | WO | disclosed |