Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | FABP4 | P15090 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6315318 | 1.00 | THRB (0.34) | THRBTDP1PIN1ALDH1A1AKR1C1 | |
| SCHEMBL5914861 | 1.00 | THRB (0.34) | THRBTDP1PIN1ALDH1A1AKR1C1 | |
| SCHEMBL5711331 | 0.84 | MEN1 (0.41) | ALDH1A1NTRK1SMN1; SMN2ALOX5MAPT | |
| SCHEMBL1534233 | 0.81 | HTR2B (0.44) | THRBTDP1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6315068 | 0.81 | OPRM1 (0.40) | ALDH1A1SMN1; SMN2ALOX5MAPTNPC1 | |
| SCHEMBL6401268 | 0.81 | OPRM1 (0.40) | ALDH1A1SMN1; SMN2ALOX5MAPTNPC1 | |
| SCHEMBL6315750 | 0.78 | HTR2B (0.39) | TDP1PIN1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL27769543 | 0.78 | ALDH1A1 (0.35) | PIN1ALDH1A1SMN1; SMN2ALOX5MAPT | |
| SCHEMBL6988447 | 0.76 | ALOX5 (0.33) | TDP1PIN1ALDH1A1NTRK1SMN1; SMN2 | |
| SCHEMBL6982545 | 0.76 | ALOX5 (0.33) | TDP1PIN1ALDH1A1NTRK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1529037-B1 | SYNTHESIS OF 2-ALKYLCYSTEINES, 2-(HYDROXYLATED PHENYL)-4-ALKYLTHIAZOLINE-4-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF | GENZYME CORP (US) | 2009-07-15 | — | — | EP | disclosed |
| US-6894170-B2 | Process for the preparation of substituted thiazolines and their intermediates | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) | 2005-05-17 | — | — | US | disclosed |
| US-20050101782-A1 | Process for the preparation of substituted thiazolines and their intermediates | KRICH SYLVIA (AT) | 2005-05-12 | — | — | US | disclosed |
| EP-1529037-A2 | SYNTHESIS OF 2-ALKYLCYSTEINES, 2-(HYDROXYLATED PHENYL)-4-ALKYLTHIAZOLINE-4-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF | Genzyme Corporation (US) | 2005-05-11 | — | — | EP | disclosed |
| US-6861532-B2 | Synthesis of 2-alkylcysteine | GENZYME CORPORATION (US) | 2005-03-01 | — | — | US | disclosed |
| US-20030229231-A1 | Synthesis of 2-alkylcysteine | GENZYME CORPORATION | 2003-12-11 | — | — | US | disclosed |
| WO-2003097622-A2 | SYNTHESIS OF 2-ALKYLCYSTEINES, 2-(HYDROXYLATED PHENYL)-4-ALKYLTHIAZOLINE-4-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF | GENZYME CORPORATION (US) | 2003-11-27 | — | — | WO | disclosed |
| US-20030088105-A1 | Process for the preparation of substituted thiazolines and their intermediates | DSM FINE CHEMICALS AUSTRIA NFG GMBH & COKG (AT) | 2003-05-08 | — | — | US | disclosed |
| EP-1302467-A2 | Process for the preparation of substituted thiazoline derivatives and their intermediate | DSM Fine Chemicals Austria Nfg GmbH & Co KG (AT) | 2003-04-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229231-A1 | Synthesis of 2-alkylcysteine | FTH1, CISD2, CNDP2 | THRB 3029/4885TDP1 4381/4885PIN1 991/4885 |
| US-20030088105-A1 | Process for the preparation of substituted thiazolines and their intermediates | CBR1, RCOR1, MT-CO1 | THRB 1563/4885TDP1 1993/4885PIN1 2758/4885 |
| US-20050101782-A1 | Process for the preparation of substituted thiazolines and their intermediates | CBR1, CBR3, MT-CO1 | THRB 1821/4885TDP1 1584/4885PIN1 2518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.