Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | CDC25B | P30305 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.36 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.36 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1650480 | 0.62 | IDO1 (1.00) | IDO1CDC25BMAOAMAOBAKT1 | |
| SCHEMBL10904924 | 0.60 | CDC25B (0.47) | IDO1CDC25BMAOAMAOBAKT1 | |
| SCHEMBL11831515 | 0.59 | IDO1 (0.43) | IDO1CDC25BMAOAMAOBAKT1 | |
| SCHEMBL6407655 | 0.59 | IDO1 (0.54) | IDO1CDC25BMAOAMAOBAKT1 | |
| Naphthoquinone SCHEMBL14763779 | 0.58 | IDO1 (0.93) | IDO1CDC25BMAOAMAOBAKT1 | |
| SCHEMBL12390669 | 0.57 | IDO1 (0.41) | IDO1CDC25BMAOAMAOBAKT1 | |
| Naphthoquinone SCHEMBL14764194 | 0.56 | CDC25B (0.88) | IDO1CDC25BMAOAMAOBAKT1 | |
| SCHEMBL7400922 | 0.55 | CDC25B (0.48) | IDO1CDC25BMAOAMAOBAKT1 | |
| Naphthoquinone SCHEMBL11359780 | 0.54 | IDO1 (1.00) | IDO1CDC25BMAOAMAOBAKT1 | |
| Naphthoquinone SCHEMBL8861335 | 0.54 | IDO1 (1.00) | IDO1CDC25BMAOAMAOBAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11130737-B2 | Multifunctional aminoquinoline therapeutic agents | LOHOCLA RESEARCH CORPORATION (US) | 2021-09-28 | — | — | US | disclosed |
| EP-3846813-A1 | ANALGESIC COMPOSITIONS | Lohocla Research Corporation (US) | 2021-07-14 | — | — | EP | disclosed |
| US-20200095204-A1 | MULTIFUNCTIONAL AMINOQUINOLINE THERAPEUTIC AGENTS | LOHOCLA RESEARCH CORPORATION | 2020-03-26 | — | — | US | disclosed |
| US-10435371-B2 | Multifunctional aminoquinoline therapeutic agent | LOHOCLA RESEARCH CORPORATION (US) | 2019-10-08 | — | — | US | disclosed |
| US-10391088-B2 | Analgesic compositions | LOHOCLA RESEARCH CORPORATION (US) | 2019-08-27 | — | — | US | disclosed |
| US-20190099412-A1 | ANALGESIC COMPOSITIONS | LOHOCLA RESEARCH CORPORATION | 2019-04-04 | — | — | US | disclosed |
| US-20190092731-A1 | MULTIFUNCAIONAL AMINOQUINOLINE THERAPEUTIC AGENT | LOHOCLA RESEARCH CORPORATION | 2019-03-28 | — | — | US | disclosed |
| US-10112905-B2 | Multifunctional aminoquinoline therapeutic agents | LOHOCLA RESEARCH CORPORATION (US) | 2018-10-30 | — | — | US | disclosed |
| US-20170204064-A1 | MULTIFUNCTIONAL AMINOQUINOLINE THERAPEUTIC AGENTS | LOHOCLA RESEARCH CORPORATION | 2017-07-20 | — | — | US | disclosed |
| EP-3157523-A1 | MULTIFUNCTIONAL AMINOQUINOLINE THERAPEUTIC AGENTS | Lohocla Research Corporation (US) | 2017-04-26 | — | — | EP | disclosed |
| WO-2015195943-A1 | MULTIFUNCTIONAL AMINOQUINOLINE THERAPEUTIC AGENTS | LOHOCLA RESEARCH CORPORATION (US) | 2015-12-23 | — | — | WO | disclosed |
| US-20090227652-A1 | INDOLE DERIVATIVES AND METHODS OF USING THE SAME | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2009-09-10 | — | — | US | disclosed |
| EP-1863762-A4 | INDOLE DERIVATIVES AND METHODS OF USING THE SAME | UNIV COLORADO (US) | 2009-07-15 | — | — | EP | disclosed |
| EP-1863762-A1 | INDOLE DERIVATIVES AND METHODS OF USING THE SAME | The Regents of the University of Colorado (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006098884-A1 | INDOLE DERIVATIVES AND METHODS OF USING THE SAME | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2006-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11130737-B2 | Multifunctional aminoquinoline therapeutic agents | OPRK1, OPRM1, OPRD1 | IDO1 845/4885CDC25B 2967/4885MAOA 194/4885 |
| US-20090227652-A1 | INDOLE DERIVATIVES AND METHODS OF USING THE SAME | IDO1, IDO2, INMT | IDO1 1/4885CDC25B 1747/4885MAOA 76/4885 |
| US-20200095204-A1 | MULTIFUNCTIONAL AMINOQUINOLINE THERAPEUTIC AGENTS | OPRK1, OPRM1, OPRD1 | IDO1 845/4885CDC25B 2967/4885MAOA 194/4885 |
| US-10391088-B2 | Analgesic compositions | OPRK1, OPRL1, OPRM1 | IDO1 133/4885CDC25B 4214/4885MAOA 39/4885 |
| US-20190099412-A1 | ANALGESIC COMPOSITIONS | OPRK1, OPRL1, OPRM1 | IDO1 133/4885CDC25B 4214/4885MAOA 39/4885 |
| US-20190092731-A1 | MULTIFUNCAIONAL AMINOQUINOLINE THERAPEUTIC AGENT | OPRK1, OPRL1, PNMT | IDO1 1353/4885CDC25B 3164/4885MAOA 178/4885 |
| US-20170204064-A1 | MULTIFUNCTIONAL AMINOQUINOLINE THERAPEUTIC AGENTS | OPRK1, OPRM1, OPRD1 | IDO1 1027/4885CDC25B 2592/4885MAOA 334/4885 |
| US-10435371-B2 | Multifunctional aminoquinoline therapeutic agent | OPRK1, OPRM1, OPRD1 | IDO1 908/4885CDC25B 3182/4885MAOA 169/4885 |
| US-10112905-B2 | Multifunctional aminoquinoline therapeutic agents | OPRK1, OPRM1, OPRD1 | IDO1 1027/4885CDC25B 2592/4885MAOA 334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.