Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.34 |
| ▸ | CHRNG | P07510 | 1/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | CHRND | Q07001 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1539491 | 0.82 | VNN1 (0.42) | RIPK1POLB | |
| SCHEMBL3960044 | 0.80 | RIPK1 (0.41) | RIPK1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4073210 | 0.79 | CYP3A4 (0.46) | RIPK1SLC6A2ALDH1A1LMNACYP1A2 | |
| SCHEMBL1273081 | 0.79 | CYP3A4 (0.46) | RIPK1SLC6A2ALDH1A1LMNACYP1A2 | |
| SCHEMBL3724996 | 0.79 | SMN1; SMN2 (0.37) | P2RX7POLBSMN1; SMN2HSD17B10 | |
| SCHEMBL4773478 | 0.78 | LMNA (0.41) | ALDH1A1LMNAPOLBCYP3A4 | |
| SCHEMBL3950927 | 0.77 | MEN1 (0.46) | KDM4EALDH1A1CYP1A2POLBCYP3A4 | |
| SCHEMBL4374632 | 0.77 | GUCY1B2 (0.36) | POLBSMN1; SMN2 | |
| SCHEMBL4583741 | 0.76 | MMP1 (0.43) | KDM4EEPHX2NR1H4HTTPOLB | |
| SCHEMBL4594149 | 0.75 | RAB9A (0.43) | KDM4EALDH1A1POLBMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010093885-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-08-19 | — | — | WO | disclosed |