Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPME1 | Q9Y570 | 7/20 | 0.43 |
| ▸ | HTR6 | P50406 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.40 |
| ▸ | APEH | P13798 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968075 | 0.83 | PPME1 (0.55) | PPME1HTR6APEHRAPGEF4 | |
| SCHEMBL3969097 | 0.81 | NOD1 (0.43) | PPME1HTR6NOD1APEHRAPGEF4 | |
| SCHEMBL1616366 | 0.80 | PPME1 (0.60) | PPME1HTR6ALDH1A1APEH | |
| SCHEMBL3964674 | 0.80 | PPME1 (0.58) | PPME1ALDH1A1APEHRAPGEF4 | |
| SCHEMBL2457308 | 0.80 | RAPGEF4 (0.58) | PPME1ALDH1A1NOD1APEHRAPGEF4 | |
| SCHEMBL3964676 | 0.76 | PPME1 (0.45) | PPME1HTR6NOD1APEHCYP2D6 | |
| SCHEMBL15173806 | 0.75 | RAPGEF4 (0.68) | HTR6ALDH1A1NOD1KIF11RAPGEF4 | |
| SCHEMBL2464163 | 0.74 | TRIM24 (0.42) | PPME1ALDH1A1APEH | |
| SCHEMBL4001880 | 0.72 | ATM (0.65) | ALDH1A1 | |
| SCHEMBL2181734 | 0.72 | CA1 (0.58) | HTR6ALDH1A1NOD1KIF11HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044134-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |