Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPME1 | Q9Y570 | 6/20 | 0.45 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.42 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.42 |
| ▸ | APEH | P13798 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 7/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2457308 | 0.83 | RAPGEF4 (0.58) | PPME1RAPGEF4APEHNOD1TRIM24 | |
| SCHEMBL3964674 | 0.83 | PPME1 (0.58) | PPME1RAPGEF4APEHCYP3A4 | |
| SCHEMBL1616366 | 0.80 | PPME1 (0.60) | PPME1APEHHTR6TRIM24TRIM33 | |
| SCHEMBL3968075 | 0.80 | PPME1 (0.55) | PPME1RAPGEF4APEHHTR6TRIM24 | |
| SCHEMBL3967048 | 0.76 | PPME1 (0.43) | PPME1RAPGEF4APEHHTR6CYP2D6 | |
| SCHEMBL3966831 | 0.73 | MET (0.49) | PPME1HTR6CYP3A4 | |
| SCHEMBL3969097 | 0.72 | NOD1 (0.43) | PPME1RAPGEF4APEHHTR6NOD1 | |
| SCHEMBL2460281 | 0.71 | TRIM24 (0.52) | PPME1APEHHTR6TRIM24TRIM33 | |
| SCHEMBL5247297 | 0.71 | RAPGEF4 (0.60) | PPME1RAPGEF4APEHTRIM24TRIM33 | |
| SCHEMBL946643 | 0.71 | KDM4E (0.76) | HTR6CYP3A4CYP2D6NOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |