Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MMP9 | P14780 | 3/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | PPME1 | Q9Y570 | 6/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | APEH | P13798 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3967048 | 0.81 | PPME1 (0.43) | NOD1HTR6RAPGEF4PPME1APEH | |
| SCHEMBL3968075 | 0.79 | PPME1 (0.55) | MMP2MEN1KMT2AHTR6RAPGEF4 | |
| SCHEMBL1616366 | 0.77 | PPME1 (0.60) | MEN1KMT2AHTR6PPME1APEH | |
| SCHEMBL3964674 | 0.76 | PPME1 (0.58) | MMP2KMT2ARAPGEF4PPME1ACHE | |
| SCHEMBL2457308 | 0.76 | RAPGEF4 (0.58) | NOD1MMP2RAPGEF4PPME1ACHE | |
| SCHEMBL1418969 | 0.74 | ALDH1A1 (0.65) | MEN1KMT2A | |
| SCHEMBL29072217 | 0.73 | KDM4E (0.67) | NOD1MEN1KMT2AHTR6 | |
| SCHEMBL3964676 | 0.72 | PPME1 (0.45) | NOD1HTR6RAPGEF4PPME1APEH | |
| SCHEMBL28469213 | 0.71 | EPHX2 (0.48) | MMP2MMP9MMP3MMP13 | |
| SCHEMBL1156469 | 0.71 | MEN1 (0.41) | NOD1MMP2MMP9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |