Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 known ✓ | O43570 | 2/20 | 0.54 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.54 |
| ▸ | CA4 known ✓ | P22748 | 2/20 | 0.54 |
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.54 |
| ▸ | F13A1 | P00488 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | CA6 | P23280 | 2/20 | 0.54 |
| ▸ | CA5A | P35218 | 2/20 | 0.54 |
| ▸ | THPO | P40225 | 2/20 | 0.54 |
| ▸ | CA7 | P43166 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.54 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.54 |
| ▸ | CA3 | P07451 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MTOR | P42345 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3967669 | 0.84 | CA12 (0.55) | CA12F13A1CA2CYP1A2ALOX15 | |
| SCHEMBL11171595 | 0.81 | CA12 (0.59) | CA12F13A1CA2CYP1A2ALOX15 | |
| SCHEMBL10336116 | 0.81 | CA12 (0.59) | CA12F13A1CA2CYP1A2ALOX15 | |
| SCHEMBL31426982 | 0.81 | DNM1 (0.53) | CA12CA2CYP1A2ALOX15CA4 | |
| SCHEMBL28920597 | 0.79 | CA12 (0.61) | CA12F13A1CA2CYP1A2ALOX15 | |
| Trientine SCHEMBL29003404 | 0.79 | CA12 (0.61) | CA12F13A1CA2CYP1A2ALOX15 | |
| SCHEMBL12983201 | 0.78 | CA12 (0.87) | CA12F13A1CA2CYP1A2ALOX15 | |
| SCHEMBL5078139 | 0.78 | CA12 (0.87) | CA12F13A1CA2CYP1A2ALOX15 | |
| SCHEMBL9182483 | 0.78 | CA12 (0.87) | CA12F13A1CA2CYP1A2ALOX15 | |
| SCHEMBL16295924 | 0.78 | CA12 (0.87) | CA12F13A1CA2CYP1A2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1302493-B1 | Polydithiocarbamate resin | AKZO NOBEL NV (NL) | 2009-07-29 | — | — | EP | disclosed |
| US-7030205-B2 | Polydithiocarbamate resin | NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION (US) | 2006-04-18 | — | — | US | disclosed |
| US-20030083456-A1 | Polydithiocarbamate resin | AKZO NOBEL N.V. (NL) | 2003-05-01 | — | — | US | disclosed |
| EP-1302493-A2 | Polydithiocarbamate resin | National Starch and Chemical Investment Holding Corporation (US) | 2003-04-16 | — | — | EP | disclosed |