Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LSS | P48449 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5079865 | 0.84 | GPR119 (0.48) | — | |
| SCHEMBL29101926 | 0.81 | LTA4H (0.47) | NOS3NOS1NOS2CHRM2CHRM3 | |
| SCHEMBL3980096 | 0.79 | USP30 (0.46) | MCHR1 | |
| SCHEMBL3981756 | 0.79 | GPR119 (0.42) | MCHR1 | |
| SCHEMBL4374631 | 0.76 | ITGB3 (0.40) | MCHR1ALDH1A1KDM4E | |
| SCHEMBL3988676 | 0.75 | CXCR4 (0.39) | ALDH1A1POLBTSHR | |
| SCHEMBL3984573 | 0.75 | HMOX1 (0.41) | MCHR1ALDH1A1KDM4EPOLBTSHR | |
| SCHEMBL4056589 | 0.74 | ATR (0.40) | MCHR1L3MBTL3 | |
| SCHEMBL4050800 | 0.74 | ALDH1A1 (0.41) | MCHR1ALDH1A1KDM4E | |
| SCHEMBL785972 | 0.73 | JAK2 (0.54) | CHRM2CHRM3MCHR1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059516-A1 | PYRIDINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (publ) (SE) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008025798-A1 | PYRIDINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2008-03-06 | — | — | WO | disclosed |