Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.39 |
| ▸ | ATR | Q13535 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13690530 | 0.90 | ATR (0.47) | MCHR1ATRHPGDSMN1; SMN2 | |
| SCHEMBL4056589 | 0.90 | ATR (0.40) | GPR119MCHR1ATRHPGD | |
| SCHEMBL4050702 | 0.88 | GPR119 (0.46) | GPR119MCHR1ATR | |
| SCHEMBL13690504 | 0.87 | GPR119 (0.53) | GPR119 | |
| SCHEMBL4374631 | 0.86 | ITGB3 (0.40) | ALDH1A1GPR119MCHR1ATRHPGD | |
| SCHEMBL4376368 | 0.86 | MKNK1 (0.46) | ATR | |
| SCHEMBL3980484 | 0.86 | GPR119 (0.45) | GPR119MCHR1TP53SMN1; SMN2 | |
| SCHEMBL4543729 | 0.85 | MCHR1 (0.43) | ALDH1A1ALOX15HSD17B10CLK4GPR119 | |
| SCHEMBL4057842 | 0.85 | HTR1A (0.43) | HPGD | |
| SCHEMBL4060086 | 0.85 | RORC (0.46) | GPR119MCHR1ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |