Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 4/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.37 |
| ▸ | ACACB | O00763 | 2/20 | 0.36 |
| ▸ | ACACA | Q13085 | 2/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050800 | 0.90 | ALDH1A1 (0.41) | ATRGPR119MCHR1HPGD | |
| SCHEMBL4050702 | 0.88 | GPR119 (0.46) | ATRGPR119MCHR1MKNK1MKNK2 | |
| SCHEMBL4373924 | 0.88 | GPR119 (0.38) | ATRGPR119MCHR1HPGDMKNK1 | |
| SCHEMBL13690499 | 0.87 | GPR119 (0.57) | GPR119 | |
| SCHEMBL4050169 | 0.87 | GPR119 (0.57) | GPR119ACACBACACA | |
| SCHEMBL4374631 | 0.86 | ITGB3 (0.40) | ATRGPR119MCHR1HPGDITGB3 | |
| SCHEMBL4376368 | 0.86 | MKNK1 (0.46) | ATRMKNK1MKNK2L3MBTL3 | |
| SCHEMBL4060086 | 0.85 | RORC (0.46) | ATRGPR119MCHR1MTOR | |
| SCHEMBL4370580 | 0.85 | ATR (0.34) | ATRGPR119MCHR1MKNK1MKNK2 | |
| SCHEMBL4059822 | 0.82 | MCHR1 (0.41) | ATRMCHR1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |