SCHEMBL398432

SCHEMBL398432

FC(F)(F)C(Cl)=Nc1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR3E A5X5Y0 3/20 0.44
HTR3B O95264 3/20 0.44
HTR3A P46098 3/20 0.44
HTR3D Q70Z44 3/20 0.44
HTR3C Q8WXA8 3/20 0.44
SLC22A2 O15244 1/20 0.44
SLC22A1 O15245 1/20 0.44
SLC22A3 O75751 1/20 0.44
PLAU P00749 1/20 0.44
NOS1 P29475 5/20 0.43
NOS3 P29474 3/20 0.43
MAPT P10636 1/20 0.41
KMT2A Q03164 2/20 0.40
MEN1 O00255 1/20 0.40
LMNA P02545 2/20 0.39
CYP1A2 P05177 1/20 0.39
ALOX15 P16050 1/20 0.39
NFKB1 P19838 1/20 0.39
CYP2C19 P33261 1/20 0.39
BLM P54132 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL398431 1.00 HTR3E (0.44) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL1743759 1.00 HTR3E (0.44) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL5551527 0.80 PLAU (0.50) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL5551530 0.80 PLAU (0.50) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL1227408 0.80 HTR3E (0.50) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL5551549 0.80 HTR3E (0.50) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL1227404 0.80 HTR3E (0.50) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL7456811 0.79 HTR3E (0.46) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL5546939 0.78 SLC22A2 (0.48) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL5546942 0.78 SLC22A2 (0.48) HTR3EHTR3BHTR3AHTR3DHTR3C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 212 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240279364-A1 GLYCAN, AND METHOD FOR PRODUCING MEDICINE CONTAINING GLYCAN DAIICHI SANKYO COMPANY, LIMITED (JP) 2024-08-22 US claimed
WO-2024168123-A1 SYNTHESIS OF CORE 2 O-SIALYL LEWIS-X POLYSACCHARIDES BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) 2024-08-15 WO claimed
EP-4306546-A1 GLYCAN, AND METHOD FOR PRODUCING MEDICINE CONTAINING GLYCAN Daiichi Sankyo Company, Limited (JP) 2024-01-17 EP claimed
WO-2022191313-A1 GLYCAN, AND METHOD FOR PRODUCING MEDICINE CONTAINING GLYCAN 第一三共株式会社 2022-09-15 WO claimed
CN-108299523-B Disaccharide and preparation method thereof, and preparation method of polysaccharide 上海医药工业研究院 2021-05-14 CN claimed
CN-109627270-B Chemical synthesis method of Pseudomonas aeruginosa O11 serotype O antigen oligosaccharide 江南大学 2020-12-29 CN claimed
US-10870710-B2 Synthetic oligosaccharide subunits of the Psl exopolysaccharide of pseudomonas aeruginosa and uses thereof MEDIMMUNE LIMITED (GB) 2020-12-22 US claimed
CN-107226830-B Chemical synthesis method of spinetoram BEIJING UNIVERSITY OF TECHNOLOGY (CN) 2019-12-10 CN claimed
US-20260144856-A1 VACCINE AGAINST KLEBSIELLA PNEUMONIAE IDORSIA PHARMACEUTICALS LTD (CH) 2026-05-28 US disclosed
EP-4486753-B1 BROAD SPECTRUM AMINOGLYCOSIDES AND USES THEREOF REVAGENIX INC (US) 2026-05-13 EP disclosed
US-12606587-B2 Protected tetrasaccharides, their process of preparation and their use as transglucosylase acceptor substrates in the chemo-enzymatic synthesis of Shigella flexneri specific oligosaccharides INSTITUT PASTEUR (FR) 2026-04-21 US disclosed
US-20260008803-A1 SIALIDASE-RESISTANT SACCHARIDE AND METHOD OF MAKING AND USING THE SAME ACADEMIA SINICA (TW) 2026-01-08 US disclosed
US-20260007733-A1 Specific Saccharide Fragment for Development of Vibrio Cholerae Vaccines UNIV JIANGNAN (CN) 2026-01-08 US disclosed
US-20250346622-A1 NOVEL OLIGOSACCHARIDE, MANUFACTURING INTERMEDIATE FOR NOVEL OLIGOSACCHARIDE, AND METHOD FOR MANUFACTURING THESE DAIICHI SANKYO COMPANY, LIMITED (JP) 2025-11-13 US disclosed
EP-1191931-A4 1-(4-SULFAMYLARYL)-3-SUBSTITUTED-5-ARYL-2-PYRAZOLINES AS INHIBITORS OF CYCLOOXYGENASE-2 UNIV TEMPLE (US) 2002-11-27 EP disclosed
US-6376519-B1 ANTIINFLAMMATORY AGENTS, ANTICANCER AGENTS TEMPLE UNIVERSITY-OF THE COMMONWEALTH OF HIGHER EDUCATION 2002-04-23 US disclosed
EP-1191931-A1 1-(4-SULFAMYLARYL)-3-SUBSTITUTED-5-ARYL-2-PYRAZOLINES AS INHIBITORS OF CYCLOOXYGENASE-2 Temple University of the Commonwealth System of Higher Education (US) 2002-04-03 EP disclosed
WO-2000076503-A1 1-(4-SULFAMYLARYL)-3-SUBSTITUTED-5-ARYL-2-PYRAZOLINES AS INHIBITORS OF CYCLOOXYGENASE-2 TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2000-12-21 WO disclosed
WO-2000076983-A1 1-(4-ARYLSULFONYL)-3-SUBSTITUTED-5-ARYL-2-PYRAZOLINES AS INHIBITORS OF CYCLOOXYGENASE-2 TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2000-12-21 WO disclosed
US-4299831-A 2-Trifluoromethyl-3-quinoline carboxamides, analgesic and anti-inflammatory compositions and methods employing them ROUSSEL UCLAF (FR) 1981-11-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260007733-A1 Specific Saccharide Fragment for Development of Vibrio Cholerae Vaccines STT3B, ST3GAL3, HACD3 HTR3E 1037/4885HTR3B 1372/4885HTR3A 1878/4885
US-12606587-B2 Protected tetrasaccharides, their process of preparation and their use as transglucosylase acceptor substrates in the chemo-enzymatic synthesis of Shigella flexneri specific oligosaccharides GALE, SI, GBA3 HTR3E 1958/4885HTR3B 2518/4885HTR3A 2215/4885
US-20240279364-A1 GLYCAN, AND METHOD FOR PRODUCING MEDICINE CONTAINING GLYCAN FUT6, ST6GAL1, NEU2 HTR3E 3267/4885HTR3B 2163/4885HTR3A 2778/4885
US-20260144856-A1 VACCINE AGAINST KLEBSIELLA PNEUMONIAE PKLR, RPS17, OSTC HTR3E 4555/4885HTR3B 4606/4885HTR3A 4816/4885
US-20260008803-A1 SIALIDASE-RESISTANT SACCHARIDE AND METHOD OF MAKING AND USING THE SAME NEU2, ST6GAL1, NEU3 HTR3E 1496/4885HTR3B 3284/4885HTR3A 2107/4885
US-20250346622-A1 NOVEL OLIGOSACCHARIDE, MANUFACTURING INTERMEDIATE FOR NOVEL OLIGOSACCHARIDE, AND METHOD FOR MANUFACTURING THESE FUT6, FUT5, ST3GAL3 HTR3E 4034/4885HTR3B 3636/4885HTR3A 3134/4885
US-10870710-B2 Synthetic oligosaccharide subunits of the Psl exopolysaccharide of pseudomonas aeruginosa and uses thereof PSPH, STT3B, DDOST HTR3E 4804/4885HTR3B 4762/4885HTR3A 4678/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.