SCHEMBL398431

SCHEMBL398431

FC(F)(F)/C(Cl)=N/c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR3E A5X5Y0 3/20 0.44
HTR3B O95264 3/20 0.44
HTR3A P46098 3/20 0.44
HTR3D Q70Z44 3/20 0.44
HTR3C Q8WXA8 3/20 0.44
SLC22A2 O15244 1/20 0.44
SLC22A1 O15245 1/20 0.44
SLC22A3 O75751 1/20 0.44
PLAU P00749 1/20 0.44
NOS1 P29475 5/20 0.43
NOS3 P29474 3/20 0.43
MAPT P10636 1/20 0.41
KMT2A Q03164 2/20 0.40
MEN1 O00255 1/20 0.40
LMNA P02545 2/20 0.39
CYP1A2 P05177 1/20 0.39
ALOX15 P16050 1/20 0.39
NFKB1 P19838 1/20 0.39
CYP2C19 P33261 1/20 0.39
BLM P54132 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1743759 1.00 HTR3E (0.44) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL398432 1.00 HTR3E (0.44) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL5551527 0.80 PLAU (0.50) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL5551530 0.80 PLAU (0.50) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL1227408 0.80 HTR3E (0.50) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL5551549 0.80 HTR3E (0.50) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL1227404 0.80 HTR3E (0.50) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL7456811 0.79 HTR3E (0.46) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL5546939 0.78 SLC22A2 (0.48) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL5546942 0.78 SLC22A2 (0.48) HTR3EHTR3BHTR3AHTR3DHTR3C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 221 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240279364-A1 GLYCAN, AND METHOD FOR PRODUCING MEDICINE CONTAINING GLYCAN DAIICHI SANKYO COMPANY, LIMITED (JP) 2024-08-22 US claimed
EP-4306546-A1 GLYCAN, AND METHOD FOR PRODUCING MEDICINE CONTAINING GLYCAN Daiichi Sankyo Company, Limited (JP) 2024-01-17 EP claimed
WO-2022191313-A1 GLYCAN, AND METHOD FOR PRODUCING MEDICINE CONTAINING GLYCAN 第一三共株式会社 2022-09-15 WO claimed
US-10870710-B2 Synthetic oligosaccharide subunits of the Psl exopolysaccharide of pseudomonas aeruginosa and uses thereof MEDIMMUNE LIMITED (GB) 2020-12-22 US claimed
US-20260144856-A1 VACCINE AGAINST KLEBSIELLA PNEUMONIAE IDORSIA PHARMACEUTICALS LTD (CH) 2026-05-28 US disclosed
EP-4486753-B1 BROAD SPECTRUM AMINOGLYCOSIDES AND USES THEREOF REVAGENIX INC (US) 2026-05-13 EP disclosed
US-20260007733-A1 Specific Saccharide Fragment for Development of Vibrio Cholerae Vaccines UNIV JIANGNAN (CN) 2026-01-08 US disclosed
US-20260008803-A1 SIALIDASE-RESISTANT SACCHARIDE AND METHOD OF MAKING AND USING THE SAME ACADEMIA SINICA (TW) 2026-01-08 US disclosed
US-20250346622-A1 NOVEL OLIGOSACCHARIDE, MANUFACTURING INTERMEDIATE FOR NOVEL OLIGOSACCHARIDE, AND METHOD FOR MANUFACTURING THESE DAIICHI SANKYO COMPANY, LIMITED (JP) 2025-11-13 US disclosed
US-20250282809-A1 Chemical Synthesis Method for Pseudomonas aeruginosa Serotype O5 O-Antigen Oligosaccharide JIANGNAN UNIVERSITY (CN) 2025-09-11 US disclosed
US-20250282810-A1 Chemical Synthesis Method and Application of V. Cholerae Serotype O100 O-Antigen Oligosaccharides JIANGNAN UNIVERSITY (CN) 2025-09-11 US disclosed
US-20250276993-A1 PSEUDO-DISACCHARIDE COMPOUNDS UNIVERSITEIT LEIDEN (NL) 2025-09-04 US disclosed
WO-2007075946-A1 COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH VERTEX PHARMACEUTICALS INCORPORATED (US) 2007-07-05 WO disclosed
US-20070106080-A1 Process for production of 1-aryl-5-(trifluoromethyl)-1h-tetrazoles TOYO KASEI KOGYO COMPANY LIMITED (JP) 2007-05-10 US disclosed
US-20070106080-A1 Process for production of 1-aryl-5-(trifluoromethyl)-1h-tetrazoles TOYO KASEI KOGYO COMPANY LIMITED (JP) 2007-05-10 US disclosed
EP-1773816-A2 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS Vertex Pharmaceuticals Incorporated (US) 2007-04-18 EP disclosed
US-20060074075-A1 including cystic fibrosis transmembrane conductance regulator (\"CFTR\"), used for treating genetic disorders; respiratory system disorders VERTEX PHARMACEUTICALS INCORPORATED 2006-04-06 US disclosed
WO-2006002421-A2 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS VERTEX PHARMACEUTICALS INCORPORATED (US) 2006-01-05 WO disclosed
WO-2004058777-A1 TITANIUM CENTERED CATALYSTS FOR THE LIVING POLYMERIZATION OF OLEFINS CORNELL RESEARCH FOUNDATION, INC. (US) 2004-07-15 WO disclosed
US-4299831-A 2-Trifluoromethyl-3-quinoline carboxamides, analgesic and anti-inflammatory compositions and methods employing them ROUSSEL UCLAF (FR) 1981-11-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250282810-A1 Chemical Synthesis Method and Application of V. Cholerae Serotype O100 O-Antigen Oligosaccharides DDOST, OGA, DAD1 HTR3E 3214/4885HTR3B 3159/4885HTR3A 2087/4885
US-20260007733-A1 Specific Saccharide Fragment for Development of Vibrio Cholerae Vaccines STT3B, ST3GAL3, HACD3 HTR3E 1037/4885HTR3B 1372/4885HTR3A 1878/4885
US-20240279364-A1 GLYCAN, AND METHOD FOR PRODUCING MEDICINE CONTAINING GLYCAN FUT6, ST6GAL1, NEU2 HTR3E 3267/4885HTR3B 2163/4885HTR3A 2778/4885
US-20260144856-A1 VACCINE AGAINST KLEBSIELLA PNEUMONIAE PKLR, RPS17, OSTC HTR3E 4555/4885HTR3B 4606/4885HTR3A 4816/4885
US-20250276993-A1 PSEUDO-DISACCHARIDE COMPOUNDS HPSE, HEXD, HEXA HTR3E 715/4885HTR3B 1705/4885HTR3A 1952/4885
US-20070106080-A1 Process for production of 1-aryl-5-(trifluoromethyl)-1h-tetrazoles TH, NAT1, PAH HTR3E 2442/4885HTR3B 1737/4885HTR3A 1835/4885
US-20260008803-A1 SIALIDASE-RESISTANT SACCHARIDE AND METHOD OF MAKING AND USING THE SAME NEU2, ST6GAL1, NEU3 HTR3E 1496/4885HTR3B 3284/4885HTR3A 2107/4885
US-20250346622-A1 NOVEL OLIGOSACCHARIDE, MANUFACTURING INTERMEDIATE FOR NOVEL OLIGOSACCHARIDE, AND METHOD FOR MANUFACTURING THESE FUT6, FUT5, ST3GAL3 HTR3E 4034/4885HTR3B 3636/4885HTR3A 3134/4885
US-20250282809-A1 Chemical Synthesis Method for Pseudomonas aeruginosa Serotype O5 O-Antigen Oligosaccharide FUT5, FUT6, FUCA2 HTR3E 4835/4885HTR3B 4546/4885HTR3A 4314/4885
US-20060074075-A1 including cystic fibrosis transmembrane conductance regulator (\"CFTR\"), used for treating genetic disorders; respiratory system disorders CFTR, ABCC4, ABCC2 HTR3E 2954/4885HTR3B 3100/4885HTR3A 3679/4885
US-10870710-B2 Synthetic oligosaccharide subunits of the Psl exopolysaccharide of pseudomonas aeruginosa and uses thereof PSPH, STT3B, DDOST HTR3E 4804/4885HTR3B 4762/4885HTR3A 4678/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.