SCHEMBL398701

SCHEMBL398701

CCOC(=O)Cc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.73

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.73
MEN1 O00255 3/20 0.60
KMT2A Q03164 3/20 0.60
HTT P42858 2/20 0.60
MAPT P10636 2/20 0.58
KDM4E B2RXH2 1/20 0.53
ALDH1A1 P00352 4/20 0.52
SMN1; SMN2 Q16637 3/20 0.51
TDP1 Q9NUW8 1/20 0.51
KCNJ1 P48048 1/20 0.51
KCNH2 Q12809 1/20 0.51
RAB9A P51151 2/20 0.50
BCL9 O00512 1/20 0.50
CTNNB1 P35222 1/20 0.50
CYP1A2 P05177 1/20 0.50
CYP2C19 P33261 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1984377 0.98 LMNA (0.71) LMNAMEN1KMT2AHTTMAPT
SCHEMBL9314768 0.94 LMNA (0.67) LMNAMEN1KMT2AHTTMAPT
SCHEMBL8024467 0.91 LMNA (0.64) LMNAMEN1KMT2AHTTMAPT
SCHEMBL19332232 0.89 LMNA (0.61) LMNAMEN1KMT2AHTTMAPT
SCHEMBL7524136 0.89 MAOB (0.64) LMNAMEN1KMT2AHTTMAPT
SCHEMBL19346040 0.88 LMNA (0.60) LMNAMEN1KMT2AHTTMAPT
SCHEMBL19332234 0.88 LMNA (0.60) LMNAMEN1KMT2AHTTMAPT
SCHEMBL3176303 0.88 LMNA (0.63) LMNAMEN1KMT2AHTTMAPT
SCHEMBL16280743 0.86 LMNA (0.57) LMNAMEN1KMT2AHTTMAPT
SCHEMBL161867 0.85 LMNA (0.56) LMNAMEN1KMT2AHTTMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 634 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110760565-A Detection kit for paraoxonase 1 and preparation method thereof 苏州普瑞斯生物科技有限公司 2020-02-07 CN claimed
CN-109402213-A A kind of method that Enzymatic Resolution prepares (R) -1- (2- naphthalene) ethamine 江苏理工学院 2019-03-01 CN claimed
CN-104744287-A Actarit production method CHU HAIYAN 2015-07-01 CN claimed
CN-101650312-A Method for detecting serum paraoxonase activity HENAN INST ENGINEERING 2010-02-17 CN claimed
US-5164515-A Chemical compounds WENDSTONE CHEMICALS PLC (GB) 1992-11-17 US claimed
EP-0239354-A2 2,2-Dinitrophenylethane derivatives and their application as protecting compounds Wendstone Chemicals P.L.C. (GB) 1987-09-30 EP claimed
US-20250388593-A1 CEREBLON E3 LIGASE BINDING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PRODUCTION METHOD THEREFOR MITSUBISHI TANABE PHARMA CORPORATION (JP) 2025-12-25 US disclosed
EP-4651872-A1 COMPOUNDS, COMPOSITIONS AND METHODS OF USE TO TREAT HYPOPARATHYROIDISM AND OSTEOPOROSIS Septerna, Inc. (US) 2025-11-26 EP disclosed
EP-4650348-A1 CEREBLON E3 LIGASE BINDING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PRODUCTION METHOD THEREFOR Mitsubishi Tanabe Pharma Corporation (JP) 2025-11-19 EP disclosed
US-20250340528-A1 TARGETED PROTEIN DEGRADATION MONTE ROSA THERAPEUTICS AG (CH) 2025-11-06 US disclosed
US-12459920-B2 Targeted protein degradation MONTE ROSA THERAPEUTICS AG (CH) 2025-11-04 US disclosed
US-12435181-B2 Formulations capable of reacting with or removal of molecular oxygen LI SHENSHEN (US) 2025-10-07 US disclosed
US-20250289785-A1 INDOLE DERIVATIVE, METHOD FOR PREPARING SAME, AND USE THEREOF MITOIMMUNE THERAPEUTICS INC. (KR) 2025-09-18 US disclosed
EP-0003670-A1 Preparation of alkyl 2-aryl acrylates COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 1979-08-22 EP disclosed
US-4163788-A ANTIINFLAMMATORY CIBA-GEIGY CORPORATION (US) 1979-08-07 US disclosed
US-4126691-A ANTIINFLAMMATORY CIBA-GEIGY CORPORATION (US) 1978-11-21 US disclosed
US-4081275-A Photographic film units containing colorless para-nitrobenzylidene dye-forming compounds EASTMAN KODAK COMPANY (US) 1978-03-28 US disclosed
US-3997669-A ANTIINFLAMMATORY CIBA-GEIGY CORPORATION (US) 1976-12-14 US disclosed
US-3993763-A ALPHA-(CYCLIC TERTIARY AMINO-PHENYL)-ALIPHATIC ACIDS CIBA-GEIGY CORPORATION (US) 1976-11-23 US disclosed
US-3936467-A ANTIINFLAMMATORY CIBA-GEIGY CORPORATION (US) 1976-02-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250289785-A1 INDOLE DERIVATIVE, METHOD FOR PREPARING SAME, AND USE THEREOF AIFM2, AIFM1, HMOX1 LMNA 1625/4885MEN1 813/4885KMT2A 4547/4885
US-12459920-B2 Targeted protein degradation NEK7, NEK1, RIPK1 LMNA 1246/4885MEN1 2268/4885KMT2A 3301/4885
US-20250388593-A1 CEREBLON E3 LIGASE BINDING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PRODUCTION METHOD THEREFOR CRBN, CUL1, CBL LMNA 3163/4885MEN1 859/4885KMT2A 663/4885
US-20250340528-A1 TARGETED PROTEIN DEGRADATION NEK7, NEK1, RIPK1 LMNA 1266/4885MEN1 2259/4885KMT2A 3318/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.