Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ACP1 | P24666 | 2/20 | 0.53 |
| ▸ | NNMT | P40261 | 1/20 | 0.50 |
| ▸ | XPO1 | O14980 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.48 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.44 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.44 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.44 |
| ▸ | RHOC | P08134 | 1/20 | 0.44 |
| ▸ | RHOA | P61586 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL263685 | 0.90 | LMNA (0.65) | LMNAACP1NNMTALDH1A1TACR1 | |
| SCHEMBL3063974 | 0.84 | KMT2A (0.48) | LMNAALDH1A1MAPTP2RX1P2RX7 | |
| SCHEMBL4224760 | 0.84 | LMNA (0.54) | LMNAACP1XPO1ALDH1A1TACR1 | |
| SCHEMBL22387603 | 0.83 | MAPT (0.53) | LMNAACP1NNMTALDH1A1TACR1 | |
| SCHEMBL25797243 | 0.83 | LMNA (0.53) | LMNAACP1NNMTALDH1A1TACR1 | |
| SCHEMBL20560661 | 0.81 | XPO1 (0.52) | LMNAACP1XPO1GPR35HDAC3 | |
| SCHEMBL18763045 | 0.81 | NNMT (0.57) | LMNAACP1NNMTALDH1A1TACR1 | |
| SCHEMBL3620508 | 0.80 | GPR35 (0.58) | LMNAACP1XPO1ALDH1A1TACR1 | |
| SCHEMBL11738143 | 0.79 | LMNA (0.59) | LMNAACP1ALDH1A1TACR1GPR35 | |
| SCHEMBL30977688 | 0.78 | MAPT (0.54) | LMNAACP1XPO1GPR35HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528134-B2 | Acetamides and benzamides that are useful in treating sexual dysfunction | ABBOTT LABORATORIES INC. (US) | 2009-05-05 | — | — | US | disclosed |
| US-20060009461-A1 | Acetamides and benzamides that are useful in treating sexual dysfunction | BHATIA PRAMILA A | 2006-01-12 | — | — | US | disclosed |
| US-20040029887-A1 | Acetamides and benzamides that are useful in treating sexual dysfunction | ABBOTT LABORATORIES | 2004-02-12 | — | — | US | disclosed |
| US-20030232836-A1 | Acetamides and benzamides that are useful in treating sexual dysfunction | ABBOTT LABORATORIES | 2003-12-18 | — | — | US | disclosed |
| US-20030229094-A1 | Acetamides and benzamides that are useful in treating sexual dysfunction | ABBOTT LABORATORIES | 2003-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229094-A1 | Acetamides and benzamides that are useful in treating sexual dysfunction | CATSPER1, CYP19A1, PDE12 | LMNA 4331/4885ACP1 3831/4885NNMT 611/4885 |
| US-20040029887-A1 | Acetamides and benzamides that are useful in treating sexual dysfunction | CATSPER1, CYP19A1, PDE12 | LMNA 4331/4885ACP1 3831/4885NNMT 611/4885 |
| US-20060009461-A1 | Acetamides and benzamides that are useful in treating sexual dysfunction | PDE12, NAAA, CYP19A1 | LMNA 4410/4885ACP1 4126/4885NNMT 324/4885 |
| US-20030232836-A1 | Acetamides and benzamides that are useful in treating sexual dysfunction | CATSPER1, CYP19A1, PDE12 | LMNA 4331/4885ACP1 3831/4885NNMT 611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.