SCHEMBL263685

SCHEMBL263685

O=C(CCl)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.65

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.65
ACP1 P24666 2/20 0.63
ALDH1A1 P00352 2/20 0.56
TACR1 P25103 1/20 0.56
MAPT P10636 1/20 0.56
NNMT P40261 1/20 0.54
GPR35 Q9HC97 1/20 0.53
P2RX1 P51575 2/20 0.51
RHOC P08134 3/20 0.51
RHOA P61586 3/20 0.51
JUN P05412 2/20 0.50
NFKB1 P19838 2/20 0.50
NFKB2 Q00653 2/20 0.50
RELA Q04206 2/20 0.50
THRB P10828 1/20 0.50
P2RX4 Q99571 1/20 0.50
P2RX7 Q99572 1/20 0.50
TMPRSS4 Q9NRS4 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4013181 0.90 LMNA (0.54) LMNAACP1ALDH1A1TACR1MAPT
SCHEMBL25797243 0.89 LMNA (0.53) LMNAACP1ALDH1A1TACR1MAPT
SCHEMBL22387603 0.89 MAPT (0.53) LMNAACP1ALDH1A1TACR1MAPT
SCHEMBL11738143 0.88 LMNA (0.59) LMNAACP1ALDH1A1TACR1MAPT
SCHEMBL18763045 0.87 NNMT (0.57) LMNAACP1ALDH1A1TACR1MAPT
SCHEMBL11438532 0.86 MAPT (0.58) LMNAACP1ALDH1A1TACR1MAPT
SCHEMBL965028 0.83 MAPT (0.70) LMNAALDH1A1MAPT
SCHEMBL10750113 0.81 LMNA (0.65) LMNAACP1ALDH1A1TACR1MAPT
SCHEMBL14263848 0.81 ALDH1A1 (0.65) LMNAACP1ALDH1A1TACR1MAPT
SCHEMBL4008934 0.81 EPHX2 (0.63) LMNAALDH1A1MAPTRHOCRHOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12623942-B2 Method for extracting salts and temperature- regenerated extracting composition ADIONICS (FR) 2026-05-12 US disclosed
CN-113292128-B Apparatus and method for desalting water by thermal deionization and liquid phase ion extraction 艾迪奥尼克斯公司 2024-07-05 CN disclosed
US-20230382775-A1 METHOD FOR EXTRACTING SALTS AND TEMPERATURE-REGENERATED EXTRACTING COMPOSITION ADIONICS (FR) 2023-11-30 US disclosed
US-20230337677-A1 ARYL AND PYRIDYL AMIDE PESTICIDES AND COMPOSITIONS THEREOF UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED 2023-10-26 US disclosed
US-11772997-B2 Method for extracting salts and temperature-regenerated extracting composition ADIONICS (FR) 2023-10-03 US disclosed
US-11731933-B2 Device and method for the desalination of water by means of thermal deionisation and liquid-phase ion extraction liquid ADIONICS (FR) 2023-08-22 US disclosed
WO-2023125751-A1 DIA-BASED QUANTITATIVE CHEMICAL PROTEOMICS TARGET SCREENING METHOD 北京大学 2023-07-06 WO disclosed
US-20220298213-A1 IN VIVO ENGINEERED CEREBLON PROTEIN VIVIDION THERAPEUTICS, INC. 2022-09-22 US disclosed
CN-109641160-B Method for extracting salt and temperature-regenerated extraction composition 艾迪奥尼克斯公司 2022-02-25 CN disclosed
EP-3247677-B1 LIQUID ORGANIC COMPOSITION FOR ION EXTRACTION IN LIQUID PHASE ADIONICS (FR) 2021-12-08 EP disclosed
US-20100063030-A1 Benzenesulfonyl Compounds and the Use Thereof PURDUE PHARMA L.P. (US) 2010-03-11 US disclosed
US-20090298878-A1 OXIME COMPOUNDS AND THE USE THEREOF PURDUE PHARMA L.P. 2009-12-03 US disclosed
EP-2040698-A2 OXIME COMPOUNDS AND THE USE THEREOF SHIONOGI & CO., LTD. (JP) 2009-04-01 EP disclosed
WO-2008138126-A1 BICYCLIC PYRIMIDINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS NEUROMED PHARMACEUTICALS LTD. (CA) 2008-11-20 WO disclosed
WO-2008138126-A1 BICYCLIC PYRIMIDINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS NEUROMED PHARMACEUTICALS LTD. (CA) 2008-11-20 WO disclosed
US-20080280900-A1 BICYCLIC PYRIMIDINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS ZALICUS PHARMACEUTICALS LTD. (CA) 2008-11-13 US disclosed
US-20080280900-A1 BICYCLIC PYRIMIDINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS ZALICUS PHARMACEUTICALS LTD. (CA) 2008-11-13 US disclosed
US-20080280900-A1 BICYCLIC PYRIMIDINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS ZALICUS PHARMACEUTICALS LTD. (CA) 2008-11-13 US disclosed
WO-2008124118-A1 BENZENESULFONYL COMPOUNDS AND THE USE THEROF PURDUE PHARMA L.P. (DE) 2008-10-16 WO disclosed
WO-2008008398-A2 OXIME COMPOUNDS AND THE USE THEREOF SHIONOGI & CO., LTD. (JP) 2008-01-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080280900-A1 BICYCLIC PYRIMIDINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS CACNA1E, CACNA1G, RYR1 LMNA 2366/4885ACP1 3703/4885ALDH1A1 3805/4885
US-20220298213-A1 IN VIVO ENGINEERED CEREBLON PROTEIN CRBN, CDR2, DCUN1D4 LMNA 1798/4885ACP1 1014/4885ALDH1A1 2798/4885
US-11731933-B2 Device and method for the desalination of water by means of thermal deionisation and liquid-phase ion extraction liquid AQP3, AQP1, AQP4 LMNA 1748/4885ACP1 2948/4885ALDH1A1 3499/4885
US-20090298878-A1 OXIME COMPOUNDS AND THE USE THEREOF KCNN4, CACNA1A, KCNN3 LMNA 3822/4885ACP1 2711/4885ALDH1A1 2105/4885
US-12623942-B2 Method for extracting salts and temperature- regenerated extracting composition POLQ, NONO, AQP3 LMNA 1141/4885ACP1 688/4885ALDH1A1 3793/4885
US-20100063030-A1 Benzenesulfonyl Compounds and the Use Thereof CACNA1A, CACNA1I, TRPV1 LMNA 1564/4885ACP1 4411/4885ALDH1A1 1627/4885
US-20230337677-A1 ARYL AND PYRIDYL AMIDE PESTICIDES AND COMPOSITIONS THEREOF DDT, ACHE, AHR LMNA 3407/4885ACP1 162/4885ALDH1A1 2254/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.