SCHEMBL18763045

SCHEMBL18763045

O=C(CCl)Nc1cc(C(=O)O)cc(C(F)(F)F)c1

nearest known ligand 0.57

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NNMT P40261 1/20 0.57
LMNA P02545 1/20 0.55
ACP1 P24666 2/20 0.50
ALDH1A1 P00352 2/20 0.49
TACR1 P25103 1/20 0.49
GPR35 Q9HC97 1/20 0.49
AKR1C3 P42330 1/20 0.48
AKR1C2 P52895 1/20 0.48
P2RX1 P51575 2/20 0.48
RHOC P08134 5/20 0.46
RHOA P61586 5/20 0.46
TRPA1 O75762 1/20 0.45
CYP1A2 P05177 1/20 0.45
MAPT P10636 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL263685 0.87 LMNA (0.65) NNMTLMNAACP1ALDH1A1TACR1
SCHEMBL782086 0.84 GAA (0.56) LMNAALDH1A1MAPT
SCHEMBL22832993 0.84 KMT2A (0.54) LMNAALDH1A1MAPT
SCHEMBL22075943 0.83 RHOC (0.60) NNMTLMNAACP1ALDH1A1TACR1
SCHEMBL4013181 0.81 LMNA (0.54) NNMTLMNAACP1ALDH1A1TACR1
SCHEMBL22387603 0.80 MAPT (0.53) NNMTLMNAACP1ALDH1A1TACR1
SCHEMBL25797243 0.80 LMNA (0.53) NNMTLMNAACP1ALDH1A1TACR1
SCHEMBL3529269 0.80 GPR35 (0.53) LMNAALDH1A1TACR1GPR35AKR1C3
SCHEMBL5950455 0.78 MAPT (0.62) LMNAACP1TACR1GPR35AKR1C3
SCHEMBL24554571 0.77 AKR1C3 (0.55) LMNAGPR35AKR1C3AKR1C2P2RX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240131032-A1 AN ACTIVITY-GUIDED MAP OF ELECTROPHILE-CYSTEINE INTERACTIONS IN PRIMARY HUMAN IMMUNE CELLS THE SCRIPPS RESEARCH INSTITUTE 2024-04-25 US disclosed
US-20240123078-A1 COMPOUNDS AND METHODS FOR MODULATING IMMUNE-RELATED PROTEINS VIVIDION THERAPEUTICS, INC. 2024-04-18 US disclosed
US-20220298213-A1 IN VIVO ENGINEERED CEREBLON PROTEIN VIVIDION THERAPEUTICS, INC. 2022-09-22 US disclosed
EP-4045050-A1 AN ACTIVITY-GUIDED MAP OF ELECTROPHILE-CYSTEINE INTERACTIONS IN PRIMARY HUMAN IMMUNE CELLS The Scripps Research Institute (US) 2022-08-24 EP disclosed
EP-4045043-A1 COMPOUNDS AND METHODS FOR MODULATING IMMUNE-RELATED PROTEINS Vividion Therapeutics, Inc. (US) 2022-08-24 EP disclosed
WO-2021076703-A1 COMPOUNDS AND METHODS FOR MODULATING IMMUNE-RELATED PROTEINS VIVIDION THERAPEUTICS, INC. (US) 2021-04-22 WO disclosed
WO-2021076755-A1 AN ACTIVITY-GUIDE MAP OF ELECTROPHILE-CYSTEINE INTERACTIONS IN PRIMARY HUMAN IMMUNE CELLS THE SCRIPPS RESEARCH INSTITUTE (US) 2021-04-22 WO disclosed
WO-2021076755-A1 AN ACTIVITY-GUIDE MAP OF ELECTROPHILE-CYSTEINE INTERACTIONS IN PRIMARY HUMAN IMMUNE CELLS THE SCRIPPS RESEARCH INSTITUTE (US) 2021-04-22 WO disclosed
US-20210002337-A1 IN VIVO ENGINEERED CEREBLON PROTEIN THE SCRIPPS RESEARCH INSTITUTE 2021-01-07 US disclosed
US-20200292555-A1 CYSTEINE REACTIVE PROBES AND USES THEREOF THE SCRIPPS RESEARCH INSTITUTE 2020-09-17 US disclosed
US-10670605-B2 Cysteine reactive probes and uses thereof THE SCRIPPS RESEARCH INSTITUTE (US) 2020-06-02 US disclosed
US-10670605-B2 Cysteine reactive probes and uses thereof THE SCRIPPS RESEARCH INSTITUTE (US) 2020-06-02 US disclosed
US-20190216893-A1 COMPOSITIONS AND METHODS OF MODULATING IMMUNE RESPONSE THE SCRIPPS RESEARCH INSTITUTE 2019-07-18 US disclosed
US-20190216893-A1 COMPOSITIONS AND METHODS OF MODULATING IMMUNE RESPONSE THE SCRIPPS RESEARCH INSTITUTE 2019-07-18 US disclosed
EP-3365686-A1 CYSTEINE REACTIVE PROBES AND USES THEREOF The Scripps Research Institute (US) 2018-08-29 EP disclosed
WO-2017205972-A1 SYSTEMS METHODS AND COMPOSITIONS FOR PREDICTING METASTASIS IN BLADDER CANCER GENOMEDX BIOSCIENCES, INC. (CA) 2017-12-07 WO disclosed
WO-2017070611-A1 CYSTEINE REACTIVE PROBES AND USES THEREOF THE SCRIPPS RESEARCH INSTITUTE (US) 2017-04-27 WO disclosed
US-20170115303-A1 CYSTEINE REACTIVE PROBES AND USES THEREOF THE SCRIPPS RESEARCH INSTITUTE 2017-04-27 US disclosed
US-20170115303-A1 CYSTEINE REACTIVE PROBES AND USES THEREOF THE SCRIPPS RESEARCH INSTITUTE 2017-04-27 US disclosed
WO-2017070611-A1 CYSTEINE REACTIVE PROBES AND USES THEREOF THE SCRIPPS RESEARCH INSTITUTE (US) 2017-04-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220298213-A1 IN VIVO ENGINEERED CEREBLON PROTEIN CRBN, CDR2, DCUN1D4 NNMT 2005/4885LMNA 1798/4885ACP1 1014/4885
US-20240123078-A1 COMPOUNDS AND METHODS FOR MODULATING IMMUNE-RELATED PROTEINS CD4, ICOS, NFATC1 NNMT 2701/4885LMNA 4512/4885ACP1 1310/4885
US-20190216893-A1 COMPOSITIONS AND METHODS OF MODULATING IMMUNE RESPONSE IFNG, MYD88, ICOS NNMT 3078/4885LMNA 4208/4885ACP1 1911/4885
US-20240131032-A1 AN ACTIVITY-GUIDED MAP OF ELECTROPHILE-CYSTEINE INTERACTIONS IN PRIMARY HUMAN IMMUNE CELLS GSTK1, GSTA2, GSTA1 NNMT 799/4885LMNA 4748/4885ACP1 2674/4885
US-20210002337-A1 IN VIVO ENGINEERED CEREBLON PROTEIN CRBN, CDR2, DCUN1D4 NNMT 2005/4885LMNA 1798/4885ACP1 1014/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.