Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PLA2G6 | O60733 | 2/20 | 0.34 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.34 |
| ▸ | CTRC | Q99895 | 3/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6698320 | 0.81 | — | — | |
| SCHEMBL7894644 | 0.79 | MMP9 (0.35) | MMP9CALM1SORT1MEN1ELANE | |
| SCHEMBL11125426 | 0.78 | CTRB1 (0.38) | MMP9CALM1SORT1MEN1ELANE | |
| SCHEMBL6702045 | 0.73 | — | — | |
| SCHEMBL6135974 | 0.70 | — | — | |
| SCHEMBL3379728 | 0.69 | USP1 (0.41) | MMP9MEN1KMT2A | |
| SCHEMBL6136392 | 0.68 | — | — | |
| SCHEMBL15282389 | 0.68 | MMP9 (0.45) | MMP9CALM1DAOLMNA | |
| SCHEMBL15282017 | 0.67 | TAAR1 (0.40) | MMP9CALM1 | |
| SCHEMBL7894646 | 0.64 | HPGD (0.38) | CALM1SORT1MEN1ELANEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552206-B2 | NF-κB inhibitors and uses thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2013-10-08 | — | — | US | disclosed |
| US-20090275603-A1 | NF- kB Inhibitors And Uses Thereof | MICHIGAN STATE UNIVERSITY | 2009-11-05 | — | — | US | disclosed |
| EP-1534686-B1 | NF-KB INHIBITORS AND USES THEREOF | UNIV MICHIGAN STATE (US) | 2009-05-20 | — | — | EP | disclosed |
| US-7528161-B2 | NF-kappaB inhibitors and uses thereof | MICHIGAN STATE UNIVERSITY (US) | 2009-05-05 | — | — | US | disclosed |
| EP-2034994-A2 | NF-KAPPA B INHIBITORS AND USES THEREOF | The Board Of Trustees Operating Michigan State University (US) | 2009-03-18 | — | — | EP | disclosed |
| US-20080114015-A1 | NF-kB inhibitors and uses thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2008-05-15 | — | — | US | disclosed |
| US-7345078-B2 | NF-κB inhibitors and uses thereof | THE BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2008-03-18 | — | — | US | disclosed |
| WO-2007133790-A2 | NF-ϰB INHIBITORS AND USES THEREOF | THE BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) | 2007-11-22 | — | — | WO | disclosed |
| US-20050020586-A1 | NF-kappaB inhibitors and uses thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2005-01-27 | — | — | US | disclosed |
| US-20030232998-A1 | NF-kB inhibitors and uses threreof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2003-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275603-A1 | NF- kB Inhibitors And Uses Thereof | NFKBIA, IKBKB, IKBKG | MMP9 3388/4885CALM1 4031/4885SORT1 4697/4885 |
| US-20030232998-A1 | NF-kB inhibitors and uses threreof | NFKBIA, IKBKB, IKBKG | MMP9 4175/4885CALM1 4073/4885SORT1 4392/4885 |
| US-20050020586-A1 | NF-kappaB inhibitors and uses thereof | NFKBIA, IKBKB, IKBKG | MMP9 3918/4885CALM1 4196/4885SORT1 4752/4885 |
| US-20080114015-A1 | NF-kB inhibitors and uses thereof | NFKBIA, IKBKB, NFKB1 | MMP9 2557/4885CALM1 3679/4885SORT1 4827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.