Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.32 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.30 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | STAT6 | P42226 | 1/20 | 0.30 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27652931 | 0.85 | PKM (0.31) | PKM | |
| SCHEMBL27587044 | 0.72 | GAA (0.31) | GAA | |
| SCHEMBL4333948 | 0.71 | PKM (0.36) | PKMGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6760912 | 0.70 | PKM (0.32) | PKM | |
| SCHEMBL678264 | 0.70 | GRIN2D (0.33) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL26080215 | 0.69 | PKM (0.39) | PKMGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL30452270 | 0.67 | PKM (0.42) | PKMGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3221210 | 0.67 | GRIN2D (0.31) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL4980533 | 0.67 | LMNA (0.33) | PKMGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8941059 | 0.67 | GRIN2D (0.33) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821589-B1 | COMPOSITIONS AND METHODS TO PREVENT TOXICITY INDUCED BY NONSTEROIDAL ANTIINFLAMMATORY DRUGS | NITROMED INC (US) | 2009-02-04 | — | — | EP | disclosed |
| US-20080275010-A1 | COMPOSITIONS AND METHODS TO PREVENT TOXICITY INDUCED BY NONSTEROIDAL ANTIINFLAMMATORY DRUGS | NITROMED, INC. (US) | 2008-11-06 | — | — | US | disclosed |
| EP-1336597-B1 | Hydroxyphenyl adamantanes and process for the production of the same | HONSHU CHEMICAL IND (JP) | 2008-07-16 | — | — | EP | disclosed |
| US-20060276439-A1 | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs | NITROMED, INC. (US) | 2006-12-07 | — | — | US | disclosed |
| US-20050038029-A1 | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs | NITROMED, INC. (US) | 2005-02-17 | — | — | US | disclosed |
| US-6790864-B2 | NONSTEROIDAL ANTIINFLAMMATORY DRUGS WHICH HAVE BEEN SUBSTITUTED WITH A NITROGEN MONOXIDE GROUP; COMPOSITIONS COMPRISING (I) A NONSTEROIDAL ANTIINFLAMMATORY DRUG, WHICH CAN OPTIONALLY BE SUBSTITUTED WITH A NITROGEN MONOXIDE GROUP | NITROMED, INC. | 2004-09-14 | — | — | US | disclosed |
| US-6720460-B2 | FORMING HEAT RESISTANT, MECHANICAL STRENGTH POLYMER ADDITIVES; ACID CATALYZED REACTION OF ADAMANTANE DIOL OR TRIOL WITH PHENOLIC DERIVATIVE | HONSHU CHEMICAL INDUSTRY CO., LTD. (JP) | 2004-04-13 | — | — | US | disclosed |
| US-20030187307-A1 | Hydroxyphenyl adamantanes and process for the production of the same | HONSHU CHEMICAL INDUSTRY CO., LTD. (JP) | 2003-10-02 | — | — | US | disclosed |
| EP-1336597-A1 | Hydroxyphenyl adamantanes and process for the production of the same | Honshu Chemical Industry Co., Ltd. (JP) | 2003-08-20 | — | — | EP | disclosed |
| US-20030109520-A1 | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs | NICOX S.A. (FR) | 2003-06-12 | — | — | US | disclosed |
| US-6482846-B1 | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs | NITROMED, INC. | 2002-11-19 | — | — | US | disclosed |
| US-6323234-B1 | TRANSFER OR RELEASE NITRIC OXIDE OR IS A SUBSTRATE FOR NITRIC OXIDE SYNTHASE WITH CARRIERS | NITROMED, INC. | 2001-11-27 | — | — | US | disclosed |
| US-6083515-A | TREATING INFLAMMATION, PAIN, GASTROINTESTINAL LESIONS OR FEVER IN AN ANIMAL IN NEED THEREOF WITH REDUCTION OF THE GASTROINTESTINAL TOXICITY OR RENAL TOXICITY OF THE NONSTEROIDAL ANTIINFLAMMATORY DRUG | NITROMED, INC. (US) | 2000-07-04 | — | — | US | disclosed |
| US-6048858-A | HETERORING CONTAINING A SULFONAMIDE GROUP | NITROMED, INC. (US) | 2000-04-11 | — | — | US | disclosed |
| US-6043233-A | COMPOUND THAT DONATES, TRANSFERS OR RELEASES NITRIC OXIDE, ELEVATES ENDOGENOUS LEVELS OF NITRIC OXIDE, OR IS A SUBSTRATE FOR NITRIC OXIDE SYNTHASE. | NITROMED, INC. (US) | 2000-03-28 | — | — | US | disclosed |
| US-5703073-A | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs | NITROMED, INC. (US) | 1997-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038029-A1 | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs | NOS2, NOS3, MB | PKM 2890/4885GRIN2D 3342/4885GRIN3B 1420/4885 |
| US-20080275010-A1 | COMPOSITIONS AND METHODS TO PREVENT TOXICITY INDUCED BY NONSTEROIDAL ANTIINFLAMMATORY DRUGS | NOS2, NOS3, MB | PKM 2890/4885GRIN2D 3342/4885GRIN3B 1420/4885 |
| US-20030187307-A1 | Hydroxyphenyl adamantanes and process for the production of the same | CYP8B1, DHPS, P4HA1 | PKM 1812/4885GRIN2D 2144/4885GRIN3B 1913/4885 |
| US-20030109520-A1 | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs | NOS2, NOS3, MB | PKM 2890/4885GRIN2D 3342/4885GRIN3B 1420/4885 |
| US-20060276439-A1 | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs | NOS2, NOS3, MB | PKM 2890/4885GRIN2D 3342/4885GRIN3B 1420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.