Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.31 |
| ▸ | MLYCD | O95822 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030341 | 0.88 | LPAR1 (0.39) | LPAR1S1PR1HDAC4HDAC6HDAC1 | |
| SCHEMBL4034923 | 0.80 | MEN1 (0.34) | LPAR1S1PR1S1PR3L3MBTL1PPARG | |
| SCHEMBL4029487 | 0.73 | LPAR1 (0.48) | LPAR1S1PR1TRPV1MLYCDL3MBTL1 | |
| SCHEMBL4031683 | 0.73 | TRPA1 (0.43) | LPAR1S1PR3MLYCD | |
| SCHEMBL4034622 | 0.69 | LPAR1 (0.38) | LPAR1PTPN1PPARGPPARALMNA | |
| SCHEMBL16060790 | 0.69 | POLB (0.38) | LPAR1S1PR1HDAC6HDAC1HDAC3 | |
| SCHEMBL4035140 | 0.69 | KMT2A (0.44) | MAPTNPSR1NPC1 | |
| SCHEMBL4033264 | 0.68 | LPAR1 (0.40) | LPAR1S1PR1HDAC6HDAC1HDAC3 | |
| SCHEMBL4033611 | 0.68 | LPAR1 (0.40) | LPAR1MAPTNPC1RAB9A | |
| SCHEMBL4034499 | 0.67 | LPAR1 (0.48) | LPAR1S1PR1HDAC6HDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |